Conserved Protein Domain Family
Pro-NT_NN
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pfam07421: Pro-NT_NN (this model, PSSM-Id:311390 is obsolete and has been replaced by 462161)
Neurotensin/neuromedin N precursor
This family contains the precursor of bacterial neurotensin/neuromedin N (approximately 170 residues long). This the common precursor of two biologically active related peptides, neurotensin and neuromedin N. It undergoes tissue-specific processing leading to the formation in some tissues and cancer cell lines of large peptides ending with the neurotensin or neuromedin N sequence.
Links
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Statistics
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PSSM-Id: 311390
Aligned: 11 rows
Threshold Bit Score: 220.422
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9D3P9         6 LQLVCLTLLAFSSWSLCSDSEEDVRALEADLLTNMHTSKI---SKASPPSWKMTLLNVCSLINNVNSPAEEAGDMHDDDL 82  house mouse
P10673         7 IQLVCMILLAFSSWSLCSDSEEEMKALEADLLTNMHTSKI---SKASVSSWKMTLLNVCSFVNNLNSQAEETGEFREEEL 83  dog
XP_006633673   3 fQLICLVLLFAASDGMCSDSDQEMKMIEEELLNSLYTTKV---NKQRLPSWKLSLLNMCRLINDPSRQGDDVWTSDEEGF 79  spotted gar
XP_007249308   6 MQLTSVVLLCLICSGFSSDVDEAKDAMEEEMLSSLYTSEVk-qSRHSAPLWQLPLQNMCRMLGSISESW-QDWTAEE--- 80  Mexican tetra
ALD51567       3 AQLACMLLLCFTCGGLCTDVDRDPQALEEELVRSLFPSKVakqNKQSAPYWRVSLVDLCRMLNGVSA---AELGGEGELE 79  three-spined st...
XP_005810392   3 AQLACVLLLCFPCGALCTDVEQEQRALAEELLTSLFTSKIk-hNRQTAPYWQVSLTNLCRLVGGLRQ---EAWSGEQEDE 78  southern platyfish
XP_003449243   3 TQLACMLLLCLTCGALCTDVDQEQRALEEELLSSLFTSKMk-qNKQSAPYWRVSLANLCKMLSALRQ---EAWSGEEEDE 78  Nile tilapia
XP_017207567  13 mqltsflllfllcnglcSDIDQGKRAIEDEVLRSLLTSKVk-aSRHIAPLWQLPLQDVCRMVNGLGDSWLEAWANEEAAE 91  zebrafish
XP_003221181   8 MQLACAMLLAFASWSLGSDSEEEMKALEADLLTNMYTSKV---NKAKLPPWQMTLLNICDLISNLNNQ-EETAGNTEDDL 83  green anole
XP_003771020   7 IPLVCMMFLAFTSQSLCSDSEEEMKALEADLLTNMYTSKI---NKARFPHWKMTLLNVCSLVNNLNSPAEETGETGEDEL 83  Tasmanian devil
NP_001232613   3 VQLVCVVLLALASCSLCSDSEEEMKALEADLLTNMYTSKI---NRAKLPYWKMTLLNVCNLVNNINNQMGETVEVDEEDL 79  zebra finch

Q9D3P9        83 VGKRKLP--LVLDGFSLEAMLT--IFQLQKICrsRAFQHWEI------IQEDILDNVNDKNEKEEVIKRKIPYILKRQ-L 151 house mouse
P10673        84 ITRRKFP--TALDGFSLEAMLT--IYQLQKIChsRAFQQWEL------IQEDVLDAGNDKNEKEEVIKRKIPYILKRQ-L 152 dog
XP_006633673  80 ISREQIS--TFPDSFSLEKLAD--FYQLQNLC--RILHGGE-------FNQKTEDYLDQDYKNEGPLKRKSPYILKRQ-L 145 spotted gar
XP_007249308  81 -IQTAYE--QRLSTALSQTLQD--LYNLQSVC--RILHPRE--------LHYGEEYLELDQDSENPLKRKSPYILKRQ-L 144 Mexican tetra
ALD51567      80 F--------NFVNSKTLHYLSAniIINLIYLN--KAPENRKEkyshcvILRGPQDYLE--GNRDNPLKRKSPYILKRQaA 147 three-spined st...
XP_005810392  79 EEAEA----SELREGSLPQREE--LYSLQHIC--RALQSREEr-----LLRDSVEYSE--ENGDAPLKRKSPYILKRQ-V 142 southern platyfish
XP_003449243  79 D--------GGLREGSLQLLDE--MYNLQRIC--RVLQSREEr-----LLQDSLEYSE--ENSDAPLKRKSPYILKRQ-A 138 Nile tilapia
XP_017207567  92 DTEVHADyeQRVSGTLLQMLEE--MHDIQNLC--RVLQPRE--------LQDEQEYLELEQNSDSPLKRKSPYILKRQ-L 158 zebrafish
XP_003221181  84 MTRR-----PTLDSFTLEAMLT--LYQLQKVChsRTFQQWEL------FQQDVYDPENSSQDKD-LMKRKTPYILKRQ-L 148 green anole
XP_003771020  84 VMRRQL---STLEGFNLEAMLT--IYQLQKICrsRAFQHWEL------LQEDVLESGNLNREKEEIMKRKTPYILKRQ-L 151 Tasmanian devil
NP_001232613  80 VPGRQFP--AALDGFSLEAMLT--VYQLQKVChsRAFQHWEL------LQQDALDLENSSQEKE-IMKRKNPYILKRQ-L 147 zebra finch

Q9D3P9       152 -YENKPRRPYILKRGSyYY 169 house mouse
P10673       153 -YENKPRRPYILKRGSyYY 170 dog
XP_006633673 146 -HINKPRRPYILKRST-LY 162 spotted gar
XP_007249308 145 -HTNKARRPYILKRSS-FY 161 Mexican tetra
ALD51567     148 -HTTKSRRPYILKRST-TY 164 three-spined stickleback
XP_005810392 143 aHNAKSRRPYILKRSS-VY 160 southern platyfish
XP_003449243 139 gHITKTRRPYILKRST-FY 156 Nile tilapia
XP_017207567 159 -RTNKSRRPYILKRSV-IY 175 zebrafish
XP_003221181 149 -HVNKARRPYILKRSS-YY 165 green anole
XP_003771020 152 -HVNKARRPYILKRSSsYY 169 Tasmanian devil
NP_001232613 148 -HVNKARRPYILKRSS-YY 164 zebra finch
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