Conserved Protein Domain Family
zf-FCS

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pfam06467: zf-FCS (this model, PSSM-Id:310814 is obsolete and has been replaced by 428958)
MYM-type Zinc finger with FCS sequence motif
MYM-type zinc fingers were identified in MYM family proteins. Human protein ZMYM3 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. ZMYM2 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.
Statistics
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PSSM-Id: 310814
Aligned: 40 rows
Threshold Bit Score: 35.0387
Created: 26-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q65174         56 HSSFKCWTCHLYFKTVPKfvptymRENErgeiemGVLGNFCSFSCAASY 104  African swine fever virus BA71V
Q9CU65        721 LRCVTCNYCSQLCKKGAT------KELD------GVVRDFCSEDCCKKF 757  house mouse
Q9EN01         39 DLTNNCIYCNDVIKDKIIi-----DTNN------IKVGYFCTITCKHIY 76   Amsacta moorei entomopoxvirus
A6QPH9        334 LNKSRCTICNKLTEIRHE------VSVN------NVTHKLCSNQCFNKY 370  cattle
Q9UBW7        420 LNKSRCTICGKLTEIRHE------VSFK------NMTHKLCSDHCFNRY 456  human
A2A791        336 AVRVSCSGCKKILQKGQTa-----YQRK------GSTQLFCSTLCLTGY 373  house mouse
Q9CU65        530 GKLTTCTGCRTQCRFFDmt---qcIGPN------GYMEPYCSTACMNSH 569  house mouse
XP_005204824   12 AVQVSCSGCKKVFQKGQTa-----YQRK------GSTELFCSTPCITEY 49   cattle
NP_001171458  449 ADATRCSICQKTGEVLHE------VSNG------SVVHRLCSDSCFSKF 485  house mouse
XP_005081253  677 LCCITCTYCSQTCQRGVT------EQLD------GSTWDFCSEDCKTKY 713  golden hamster
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