O43264         9 L----------------------AHSGRLEKEDLGTRISRLTRRVEEIKGEVCNMISKKYS--EFLPSMQSAQGLITQVD 64  human
O48626         1 MpeidalfesinvrdllaghdlnDPTTPLSAPDLRLLINRLESHSLRIKSKVQSYLVAHHS--DFSELFSLCQDTVSRTR 78  thale cress
O44218        10 Lpe------------------mfQSNGCASLEDTKSTVSKVQTRTERFQERVRKHIDENYS--EFMTNHTSPDIFLEESS 69  Drosophila pseu...
OCA28990       9 L----------------------ANSGRLEKEDLGTKISRLSRRVEELKGEVCDMINKKYD--EFLPSMQCAEDLVTQVH 64  western clawed ...
XP_001625466  20 L----------------------QKTGQLEQEDFNKCATKMLKKAEEVKAEVFNTIYKEYSyaGFQDLSSSTSELNWKVS 77  starlet sea ane...
CAF97316       9 L----------------------ASSGKLEKEDLSGKISKMSRKVEETKEELYEMINKRYA--DFLPSLQSSEQLMIQVD 64  spotted green p...
NP_956435      9 L----------------------ASSGKLEKDDLACKISKLSRKVEETKEEVTDMINKKYI--EFIPSMEGAEELLDQVE 64  zebrafish
XP_002634365   1 M------------------------------PSSEGSYRDLEKKLKDGLTSISADIVDKYGnlKVALNINNTAKLIFDRL 50  Caenorhabditis ...

O43264        65 KLSEDI-DLLKSRIESEVRRDLHVSTGEFTDLKQQLERDSVVLSLLKQL-QEFSTAI-----EEYNCALTEKKYVTGAQR 137 human
O48626        79 LISDDVsDVLQLVSDRPIDVEIRSVVDEITEKTKEVKLKRESLDLVNAI-VGICEAL-----QETKEALKNGRFRFAAER 152 thale cress
O44218        70 SLGREInDLLET-VGTEGLAALNGSSTQLADHSRELRELMLGLQVSEHI-LKIDELF-----QCVEEAKGTKDYLVVLDL 142 Drosophila pseu...
OCA28990      65 GLASDV-DVLKSRIETEVKSDLKVAVNEFTELKQQLEKNTVILGVLEQL-QEFDSAI-----EKYNCALASKNYISAARH 137 western clawed ...
XP_001625466  78 SLLKEI-DATTKKVKGSILPDLDAAAEEHANLVQQLKETDMVRVILIRL-GKIHLGL-----ETLPGTLKSKAFCKAAKL 150 starlet sea ane...
CAF97316      65 EVSKEM-EALKNCIKNEVWLDLNPTTKD-----RQADRSANSLFYLTSLcLQFHNAM-----EEFDKALPNKDYVEAANM 133 spotted green p...
NP_956435     65 SVSKDI-DLLKSCIENEVQQNLHDAVTEYAKLKQQLEKNTAVIDLLQHL-QEFDTAI-----EEYHRALQEKNYVVAAKQ 137 zebrafish
XP_002634365  51 ENLEDTaEMSSRELSNLIEQTEKDSPEMLAEIKTQARSCENLVEFLQSM-KKVEEQLiimrsKTTNRIEWGNAILACKDY 129 Caenorhabditis ...

O43264       138 LEEAQKCLKLLKSRKCFd-----------LKILKSLSMELTIQKQNILYHLGEEWQKLIVWKFPPSkdt-sslEsyLQTE 205 human
O48626       153 IRELKVVLRIGEEEDGE------------PVAYALLRKEWSNCFDEIQEVLAKFMENAVRFELDSS-------R--IRIK 211 thale cress
O44218       143 VGRLRSLIYG----EGEaatqdvvrifqaLECYETIKVKYHVQAHLLQQNMQERFDRLVQLNCKSF-------PnsKCVT 211 Drosophila pseu...
OCA28990     138 LEKAHSCLKVLKSRKGCe-----------LKLLKSLGIELTVQKQNLLYHLGEEWQQLAVWKLPPSken-ssvEmiLKTE 205 western clawed ...
XP_001625466 151 LEDVKEDLEHV-PRAGQe-----------GKIFIALREELRRLSIQLVNKLDTTWNNCLLWSIPTSssl-dsaHahLKTQ 217 starlet sea ane...
CAF97316     134 LERARTSVDSLKVWKLSq-----------VPLLGALSSELTVQRENLIYHLGEEWKRLIIWKLPPSndp-agpQsfLSVA 201 spotted green p...
NP_956435    138 HGTARACVDALKTWKDTe-----------LPIVRALSSEITIQRENLIYHLGEEWQKLAVWKLPSTkteltgaKsfLKTA 206 zebrafish
XP_002634365 130 LNETNLLLEGIQCEGFDm-----------SIPLKHFAAEYSVLSYNCRYQLSADYDRAMSVPKVSKkqg-gdkSnvSVTV 197 Caenorhabditis ...

O43264       206 LHLYTEQSH-----KEektpmpPISSVLLAFSVLGELHSKLKSFGQMLLKYILRPLASCPSLHAVIESQPN-I-----VI 274 human
O48626       212 YQLSVGETA-----GI------ALSTVLEAMEVIGILDYGLAKAADSIFKHVITPAVTHASTFAAVEDLCKsAgevteAT 280 thale cress
O44218       212 LLVSKEEGQ--------------LHDIVIALF---QERYNPVRLCEFLLENCIEPLILKPVGVECNENAEAgTyv--qLS 272 Drosophila pseu...
OCA28990     206 LHLCTLPSNdesttGP------LLGSVLQAFAILGELNTKLKFFSQLLLNYILKPLVTYPSLHAQMETQQQg------VI 273 western clawed ...
XP_001625466 218 LKLCTYGSE--------------ITEVINALAFLGRLEQKLKIFGKKLIQFIFRPLIIFPNLKVSVEKDKEd------IT 277 starlet sea ane...
CAF97316     202 LNLSHACVE-----GPeakpsaLLCCVLQALAIQGELQNKIKLFSQALVKSMLKPLVVHPSLWVNVVEQQDeG-----IV 271 spotted green p...
NP_956435    207 LHLNKGGSK-----VDesvphaLLSSILQALSIQGELHKKIKLFGQVLFKYILKPLILYPSLVVEVSSQPEqG-----AV 276 zebrafish
XP_002634365 198 LNLSTPEEQ-----KN-------MNETLTAMNMIGQLPERLDAWKTVIL-NVFCEAIVSSRDGVDVFFVDNpTpaqtrFL 264 Caenorhabditis ...

O43264       275 IRFESI-------MTNLEYPSPSEVFTKIRLVLEVLQKQLLDLPLDTDlenektstvplaEMLGDMIWEDLSECLIKNCL 347 human
O48626       281 LRLEQSs------DHKFEDVDGDAMYSGILKVVKFICSSLCFGNVTWI------------HSFGRLTWPRISELIISKFL 342 thale cress
O44218       273 LSYSTKesgtasgTSTQLRPNYKQVLEHFRLLLQTLSGINHSLSSSQHv----------fSIIGDHVKDRMMHLLVNDCL 342 Drosophila pseu...
OCA28990     274 LRFESV-------ETQLEHPPPSEVFIKLRLVFELLHKHLLDVPVEDSpqagetgkvvlaEVLGEMIWEEISEAIIKDCL 346 western clawed ...
XP_001625466 278 ISLVRD-------TTKCKIVEPGKVYSKIIEVLEVLCTY--FTPSQDNsglpk---isilQYLGNFLWPALSEDLIKDCL 345 starlet sea ane...
CAF97316     272 LAFESLq------ESSKERSTPSQVYSKLLMVLKTLHAHLLDVSIGDKrl---------sTILGELIWEEMSGCIIHECL 336 spotted green p...
NP_956435    277 LSLQCL-------ETKAEHPDPSQVYTKVLTVLKTLHEHLFDVSVDEKkv---------sEILGGLIWEEMSECIIRECL 340 zebrafish
XP_002634365 265 INQKPR-------GKKDKPMDVEKVLQSMDVFFSKLSDVLKSHELLDAcgk------sfvAMIGHAIQPQLNEMILKDVV 331 Caenorhabditis ...

O43264       348 VYSIP--TNSSKLQQ-YEEIIQSTEEFENALKEMRFLK-GDT-TDLLKYARNINSHFANKKCQDVIVAARNLMTSEIHNT 422 human
O48626       343 SKVVP--EDASKLAD-FQKIIERTSQFEAALKELNFVSsSDAeSRLSKYAEDVEVHFASRKKIEILAKARNLLLQCNFTI 419 thale cress
O44218       343 IPAVP--ETMEEYQA--STLCEDVAHFEQYLADSFLIN-PEVdRGLSQFIEQYGTYYRNRLCSRVLESTREIIQRDLQDM 417 Drosophila pseu...
OCA28990     347 VYSIP--NNSSKLVQ-YDEVINATEEFENALKGMNYLK-GDA-TDLLKYARNVNAHFASKKCQDVIVIARNLMTSEIHNT 421 western clawed ...
XP_001625466 346 AKSIP--NTSAQLEK-YQEVISQTEKFEEELHQLEIVD-KLP-SSLTKYAKDVGVHFGNKKCQDLLVTARDLMKDDIYNT 420 starlet sea ane...
CAF97316     337 VHSIP--NNSSELEK-YTTVIKQTEEFEKALKDMDFLQ-RDS-TDLLKYARDINCHFASKKCKDVIVAARKLMTSKMHNT 411 spotted green p...
NP_956435    341 VHSIP--ANSSQLAE-YSEVIKQTEDFESSLKEMGYLA-GDS-TELLKYARNVNCHFASKKCQDVIVAARKLMTSEMHNT 415 zebrafish
XP_002634365 332 AIAAPvtETAEEDQEmFLRLLQFGEDFVENMKTLGFFS-PDA-KLL--FSLDTDTIFVTRRCFAIVSKANKLINETYDKL 407 Caenorhabditis ...

O43264       423 Vkiipdskinvpelptpd---------------------------------------------------ednklevqkvs 451 human
O48626       420 P------------------------------------------------------------------------------- 420 thale cress
O44218       418 Vlva---------------------------------------------------------------------------- 421 Drosophila pseu...
OCA28990     422 Vkitpdskitvptlsky-----------------------------------------------------egsekiikke 448 western clawed ...
XP_001625466 421 Vmvdrftdtallvtpqeiqeallgkkskvknpvntvlkainhnyllvynahffhaeliltwqplairlpssymeyywich 500 starlet sea ane...
CAF97316     412 Vkitpdyklrlpklp--------------------------------------------------------apgpevkvk 435 spotted green p...
NP_956435    416 Vkitpeyklsipkllsps---------------------------------------------------ggekerkessk 444 zebrafish
XP_002634365 408 Vtvgvddtavkdidllsk---------------------------------------------------ahthaelyake 436 Caenorhabditis ...

O43264       452 ntqyhEVMNLEPENTLDQHSFSLPTCRISESVKKLMELAYQTLLEA-TTSSDQCAVQLFYSVRNIFHLFHDVVPTYHKEN 530 human
O48626       421 -----QDIAMRNAKHIVCLLFSSERCVVSEAASQLMNLVHKTLEDV-CVSSARVASEFYNAARDSILLYEAVVPVKLEKQ 494 thale cress
O44218       422 -------pnNQAMDVTGCDPFLFPRCMVSRSAQDFMKLMERILRQPtEKPGEDEADPLAGVIGMMLQTYIDEVPKVHKKL 494 Drosophila pseu...
OCA28990     449 nhlsqEAPGLENDVKLSQHTFALPTCRISESVQKLMELAYQTLSEA-TTSSKPCSIQLFYTVRNIFHLFYDVVPTYHKEN 527 western clawed ...
XP_001625466 501 qqeisELTKSDQEETLSEFTFNFPTCRISESTKKLMDLAYSTLIEA-TTSPFQTAVQLFYTVRNVFELYCSVVPAYHQDN 579 starlet sea ane...
CAF97316     436 peatrEELTMENAKQLSALSLCLPACRISESVQQLMELALHTLCEA-VGSSAYCALHLFITVRNVFQLFYDVVPTYHKEN 514 spotted green p...
NP_956435    445 rsghyDQQSLENEKQLSPNTLCLPVCRISESVQQLMDLAIQTLSEA-VGSSPQCGVQLFYTVRNIFHLFYDVVPTYHKDN 523 zebrafish
XP_002634365 437 ygndlARLWSHNEESQFPSFFAFQKCTVSASTISFVNLLRDNVKAAfACEDEGARAKLALTAENIVRLYVIQSPRKHAEL 516 Caenorhabditis ...

O43264       531 LQKLPQLAAIHHNNCMYIAHHLLTLGHQFRLRLAPILCDgTATFVDLVPGFRRLGTECFLAQMRAQKGELLERLSSARNF 610 human
O48626       495 LDGLNEAAVLLHNDCLYLFEEILGLAFEYRASFPSSIKE-YAVFADIAPRFKLMAEEVLQKQVHLVISSLREAIDSADGF 573 thale cress
O44218       495 LESIPQQSVLFHNNCMYFTHWVAQNANKG-----------IESFPALVKTLQATGTMHFRVQVTYQTSILMDIMES---F 560 Drosophila pseu...
OCA28990     528 LQKLPQLSAIHHNNCMYIAHHLLTLGHQFRYHLPSPLSDgAATFVDMVPGFRRLGTESFLAQMRSQKADLLERLSNARNF 607 western clawed ...
XP_001625466 580 LATLPQLSALHHNNCMYISHLLMTAGHQFSAQLPEPLGVgTVTFMDLVPTVREIGEKCLFEQLKRQRSQLLSTIRAAEGF 659 starlet sea ane...
CAF97316     515 LLKFPHLAAIQHNNCMYLAHHLLTLGHHFKAHLPQPYGRgLATFVDMVPGFRRLGARCFLAQMNVQRSELLERLSTAHNF 594 spotted green p...
NP_956435    524 FLKLPHLAAIQHNNCMFIAHHLLTLGFQFKPYLP--LKDgVAYFVDLVPGFRRLGALCFVAQMNVQKAEMLERLSTARNF 601 zebrafish
XP_002634365 517 FSSIPNMSAIFYNNCHYISHCIMTMSFEASGENQKTLLE--PLLVDSVIRLRNVAADCMEKTLTRCRREMSAYLEDHSIF 594 Caenorhabditis ...

O43264       611 SNMDDEENYSA 621 human
O48626       574 QNTHQIKQFKS 584 thale cress
O44218       561 EFESPHTLGTG 571 Drosophila pseudoobscura pseudoobscura
OCA28990     608 SNMEDEDNYTA 618 western clawed frog
XP_001625466 660 ADANEDHRSSQ 670 starlet sea anemone
CAF97316     595 CNLDDEDNYVa 605 spotted green pufferfish
NP_956435    602 SNLDDEENYSv 612 zebrafish
XP_002634365 595 EHLPASYKTTK 605 Caenorhabditis briggsae