Conserved Protein Domain Family
SLAM
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pfam06214: SLAM (this model, PSSM-Id:310659 is obsolete and has been replaced by 461853)
Signaling lymphocytic activation molecule (SLAM) protein
This family consists of several mammalian signaling lymphocytic activation molecule (SLAM) proteins. Optimal T cell activation and expansion require engagement of the TCR plus co-stimulatory signals delivered through accessory molecules. SLAM, a 70-kDa co-stimulatory molecule belonging to the Ig superfamily, is defined as a human cell surface molecule that mediates CD28-independent proliferation of human T cells and IFN-gamma production by human Th1 and Th2 clones. SLAM has also been recognized as a receptor for measles virus.
Links
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Statistics
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PSSM-Id: 310659
Aligned: 12 rows
Threshold Bit Score: 195.748
Created: 19-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9QUM4         1 MDPK-GSLSWRILLFLSLAFELSYGTGGGVMDCPV-ILQKLGQDTWLPLTNEhQINKSVNKSVRILVTMATSPGSKSNKK 78  house mouse
Q95MM9         1 MDSR-GFLSLRCLLVLALASKLSCGTGESLMNCPE-VPGKLGSSLQLSLASE-GISKRMNKSIHILVTRAESPGNSIKKK 77  dog
Q1RML5         1 MDPK-GLLSSNVLLLFSLIIELSCRTGEGLTSSTKtILGQLGSSVLLPLASE-EISRSMNKSIHILVTMAESPKDTVKKK 78  cattle
NP_001230749   1 MDPKrRLFSLNVLLLLSLAFELSCTTGEGSMNCPK-VLGRLGSSVLLPLTSE-GIRKSMNKSIHILVSMAESPVHNIKKK 78  pig
XP_002715271   1 MDTK-GYFSWSLLLVLSLAFGLSYVAGRGVMDCPK-SVQQLGSNILLPLTNE-RINKSMNKSIRIVVTVAKSPESSVKRK 77  rabbit
XP_005339418   1 MDTK-GLLSLSLLLILTLAFELSYATGGGVMNCPK-ILWPLGSDVVLPLTSE-RINKSMNKSIHILVTMAESPESSIKKK 77  thirteen-lined ...
XP_012664021   1 MDLK-RLHSLTLLLFLSLAFEQSYGIGGGMMNCPK-TLHQLGRKVLLPLTHE-GINKSMDKSIHIVVTVATSPENSVKKK 77  small-eared galago
XP_003415237   9 lnlllllslaselscgtgGHS---------MDCPK-IIQRLGSKLMLPLTYK-GINKSMSESIRIVVTMETSLGSIFKKK 77  African savanna...
XP_001504489   1 MDPR-GLLSLNFLLFLFLAFELSCGTGEGLMNCPK-ILGRLGSSVLLPLTSQ-GISKSMNESIHILVAKAESQGSSVKKK 77  horse
XP_014318288   1 MDPK-GLLSLNVLLFLSLACDRSCGT-----GCPT-IFGQLGSSVLLPLISE-GISKSMNKSIHMFITWAKSPGNRSSKK 72  little brown bat
XP_014931738   1 MDLK-GLLSLNFLLFLSLAFELSCGTGESLMTCQE-VTEQLGRNLLLPLASE-GISKSMNKSIHILVTKSESPQKNVKTK 77  cheetah
XP_004775935   1 MDPK-RLLSLNFLLFLSLAFELSCGTGESLLNCPE-IPGQLGNSVLLPLASG-GISKSMNKSVHVLVTRAESPGNSVKKK 77  domestic ferret

Q9QUM4        79 IVSFDLSKGSYPDHLEDGYHFQSKNLSLKILGNRRESEGWYLVSVEEN 126 house mouse
Q95MM9        78 IVSLDLPEGGSPRYLENGYKFHLENLTLRILESRRENEGWYFMTLEEN 125 dog
Q1RML5        79 IVSLDLRKGDSPR-LNDGYEFHLENLSLRILKSRKEDEGWYFISLEEN 125 cattle
NP_001230749  79 IVSLDLPEGSSPRYLEDGYAFHLENMSLSILESKKEDEGWYFLSLEEN 126 pig
XP_002715271  78 IVSLDLSEGGSPEYVEDGYRFHPEDLKLGLLESRKEHEGWYFLSLEEN 125 rabbit
XP_005339418  78 IVSLDPSEKGSPSYLEDGYQFHLENLSLVILGSKNDSEGWYFMSLEEN 125 thirteen-lined ground squirrel
XP_012664021  78 IVSLDPSEGGPPHYLKDRYKFHLENLSLDILESRKEDEGWYFMTLEKN 125 small-eared galago
XP_003415237  78 IVSLDPSERSSPPNLEDRYKFHLESLSLEILKSRKEDEGWYSMTMEQN 125 African savanna elephant
XP_001504489  78 IVSLSLPEGSSVGYLEDGYKFHLENLSLEIPESRKKDEGWYIMTLEGN 125 horse
XP_014318288  73 IVSLDLPEEGSSRYLEDGYKFYQENLNLEILESKKEHEGWYTMTLEKt 120 little brown bat
XP_014931738  78 IVSLSLPERASPRFLENGYKFHPENLKLEILQSKKENEGWYFTTLEEN 125 cheetah
XP_004775935  78 IASLDLPEGGSPRYLENGYTFHLENLSLGILESRKENEGWYFMTLEEN 125 domestic ferret
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