Conserved Protein Domain Family
TRAP_beta
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pfam05753: TRAP_beta (this model, PSSM-Id:310394 is obsolete and has been replaced by 399046)
Translocon-associated protein beta (TRAPB)
This family consists of several eukaryotic translocon-associated protein beta (TRAPB) or signal sequence receptor beta subunit (SSR-beta) proteins. The normal translocation of nascent polypeptides into the lumen of the endoplasmic reticulum (ER) is thought to be aided in part by a translocon-associated protein (TRAP) complex consisting of 4 protein subunits. The association of mature proteins with the ER and Golgi, or other intracellular locales, such as lysosomes, depends on the initial targeting of the nascent polypeptide to the ER membrane. A similar scenario must also exist for proteins destined for secretion.
Links
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Statistics
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PSSM-Id: 310394
Aligned: 18 rows
Threshold Bit Score: 169.063
Created: 23-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9VUZ0         9 FAlCAVFST-CLSEDET---RARLLVSKQILNKYLVEKSDLLVRYTIFNVGSGAATKVRLVD-SGF-HPEAFDVVGG--Q 80  fruit fly
Q54VI6        13 Lf-VSFVYC------EN---GAELLFHKKIVEGPVV-GKELPIQFIIYNVGSEPAYDISFID-NDF-SNAEFEFVSG--S 77  Dictyostelium d...
Q0DLG8        12 Ll-LLLVPFaAAAGQDA---PFVVAQKKVALSRPGPGVERLAVTLNLYNQGSATAYDVSLND-DSW-PQEAFQLISG--T 83  Japanese rice
Q94BY3        13 Ma-VFMLVSaSFATSEV---PFMVVHKKATLNRLKSGAERVSVSYDIYNQGSSSAYDVTLTD-NSW-DKKTFEVVNG--N 84  thale cress
Q01GX3        22 Ia-IACLALgARASDDDlatTARVLARKTIAPAMAVEGQNLTVTVSLVNAGTAEARKVRVRD-DGL-DASAFELIGEkdA 98  Ostreococcus tauri
Q21352         1 Mq-LVFLILsALAAADA---SAKILIGKSFVTKYPVAQRENAFEYQIINIGLSPALKVELSDlKSF-PTDRFEILKG--S 73  Caenorhabditis ...
XP_001625494   7 vlgvlaSLGhCAESESS---SARLIVAKNILNQFAVEGKDLTVHYTIYNVGSSPAFAVTLTE-TAF-DENSFKVKHG--L 79  starlet sea ane...
XP_002633730   1 MK-LIILVSaFLATVNA---SARVLVGKEFISMYPVAQQENVFEYQIINIGDTAAINVDFSDrGSF-PTDKFEIVSG--S 73  Caenorhabditis ...
XP_001415761  28 sfanpivaqddadasdappgPARVLVRKRIVEDLVVEGSNVTVAVTLTNAGETEARKVKARD-DGFaNEDDFELITGkeS 106 Ostreococcus lu...
XP_010655303   1 --maFILVSsTLGSSDV---PFIVTHKKASLTRLKSGDKRVSVSIDICNQGPTTAYDVSLTD-DSW-SQDVFNVVSG--N 71  wine grape

Q9VUZ0        81 PTAVVDRIAPQTNFTHVLVVRPKAFGYFNFTAAEVSY-----KAVEESETLQLAVS--SEPGEGGIVNLNEYNKRFSSH- 152 fruit fly
Q54VI6        78 SEGKWETLAPNSQVQTNLTVIPKKSGIYSLTSTVLNY-----RKTQTSSEFTVSSA--ASYSGMYVESQADYEKRTSLL- 149 Dictyostelium d...
Q0DLG8        84 TSKIVEKLDPGATASHNFILETKVQGKFQGSPAIITY-----RVPTK-AALQEAYS--TPMFPLDILAERPPQQKFELVk 155 Japanese rice
Q94BY3        85 TSKSWERLDAGGILSHSIELEAKVKGVFYGAPAVVTF-----RIPTK-PALQEAYS--TPLLPLDILADKPPTKPLDVAk 156 thale cress
Q01GX3        99 LSATYATLAPGERVEYAYTVVPKTSGSFKASAASVSYlgtsgRETTRGTSNVLGDVlvYTKTQRNIFTALEVGKYLTLGa 178 Ostreococcus tauri
Q21352        74 ATASFPVIPANSTIYHHIVVIPRVPQAIEDHDVTVNY-----TDSETGKRARTSTVsyDKRGYTHFFAETAMRKVEGVN- 147 Caenorhabditis ...
XP_001625494  80 TSIKWKSIVPGTNVSHTLILEPLKSGVFNFTSAMVTY-----KPSEDAPE-QVAFS--TAPGEGGVMSNKDYQRKHSPH- 150 starlet sea ane...
XP_002633730  74 LDAKYAVIPPHSSVSHHIVVVPRVPHAIEDKDVLVDY-----TDSESKISSRVSTLwfSKGRLTHFFHQDALKHIAGSK- 147 Caenorhabditis ...
XP_001415761 107 LSATYATIAPGESVEYSFVVVPKKSGSFPGGAVSVSYlgtsgRETTHGSSNVLGATpvYTTMQKNIFAALKVGKYLTLGa 186 Ostreococcus lu...
XP_010655303  72 TSTSWERLDVGGLLSHAFELESKMEGMFYGAPAVITF-----HIPTT-AALQEAYS--TPILPSDILAVRPPEKKFEWAk 143 wine grape

Q9VUZ0       153 ---FFDWVAFAVMTLPSLAI-----PLALWHQSKSkye-rsGK 186 fruit fly
Q54VI6       150 ---IKEWITFFVLCAGAIAL-----PYSISTYYKKnye-ngIK 183 Dictyostelium discoideum
Q0DLG8       156 t-cGEIWVAGLRCFLCRCVYlpgckPVKIHCCKRKqe--eaLN 195 Japanese rice
Q94BY3       157 r-lLAKYGSLVSVISMVVCF-----IYLVATPKSNvsk-asSK 192 thale cress
Q01GX3       179 cktMEDWVRYGTLFGGVAGA-----LALNWFALKV------KK 210 Ostreococcus tauri
Q21352       148 ---CTHFLGFGAIAFPLTAI-----PAILYWISKRrysnkkQD 182 Caenorhabditis elegans
XP_001625494 151 ---LVDWGLFSLMSIPTMLI-----PFMVWYRSHSkye-niKa 184 starlet sea anemone
XP_002633730 148 ---YAHFFVFAAIATPVTGL-----SALLYWVSKSryt-lpKR 181 Caenorhabditis briggsae
XP_001415761 187 crtIEDWVKYGTIIGSVCGA-----LLLNWVALKVkkgvaaar 224 Ostreococcus lucimarinus CCE9901
XP_010655303 144 r-lLAKYGSQISVISI---------VYLVASPSKSgagkgskk 176 wine grape
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