pfam05205: COMPASS-Shg1 (this model, PSSM-Id:310073 is obsolete and has been replaced by 461586)
COMPASS (Complex proteins associated with Set1p) component shg1
The Shg1 subunit is one of the eight subunits of the COMPASS complex, complex associated with SET1, conserved in yeasts and in other eukaryotes up to humans. It is associated with the region of the Set1 protein that is N-terminal to the C-terminus, ie Set1-560-900. The function of Shg1 seems to be to slightly inhibit histone 3 lysine 4 (H3K4) di- and tri-methylation, and it is a pioneer protein. The COMPASS complex functions to methylate the fourth lysine of Histone 3 and for silencing of genes close to the telomeres of chromosomes.
Jiyao W et al.(2023). "The conserved domain database in 2023.",