Conserved Protein Domain Family
TACC
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pfam05010: TACC (this model, PSSM-Id:309929 is obsolete and has been replaced by 461517)
Transforming acidic coiled-coil-containing protein (TACC)
This family contains the proteins TACC 1, 2 and 3 the genes for which are found concentrated in the centrosomes of eukaryotic and may play a conserved role in organising centrosomal microtubules. The human TACC proteins have been linked to cancer and TACC2 has been identified as a possible tumor suppressor (AZU-1). The functional homolog (Alp7) in Schizosaccharomyces pombe has been shown to be required for organisation of bipolar spindles.
Links
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Statistics
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PSSM-Id: 309929
Aligned: 23 rows
Threshold Bit Score: 219.508
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q95TU9       1089 HNYNDMDELEKK----IKNEVTRsediekklKEGELREeaLIKRITEKDKTNAKLNGVIEAYEKAIAELISEKEQQAQLH 1164 fruit fly
XP_010831614  552 YSQKDLDSAVEA----TQKENEV-----------------LRGKCAALQERLLEMGKIMDSFEGTVYQVMEESQKQKELT 610  Bison bison b...
XP_005208350  611 YSQKDLDSAVEA----TQKENEV-----------------LRGKCAALQERLLEMGKIMDSFEGtVYQVMEESQKQKELT 669  cattle
XP_003128852  541 YSQRDLDAAVEA----TQKENAE-----------------LRSRCTELQEKVLEMGKIMDRFEETVYQAMEEAQKQKELA 599  pig
XP_012915487  578 YSQKDLDAVVET----TREENVL-----------------LRSQCETLRARNLEMGKIMDGFEGIVYQAMEEAQKQKELA 636  domestic ferret
XP_005045602  616 YSQKDMDAAVEV----VKREVQE--------KELEIQK--LNEKYDKLRMDYREMGKIFDEFERTLLDFLADADQQKESL 681  collared flyc...
XP_007247623  804 YSQKDMDAAMER----ARKQAEE--------KEEE-----LKAQIAKMTMDNEHMVLIVSEFETIIAQITAEHKQKEELV 866  Mexican tetra
AAH95573      737 YSQKDMDAALQK----ADRQSEE--------RQQE-----LKSQIEKLQLENQQMLFIMSEFETTITQITDEHKQKEALA 799  zebrafish
XP_011141343  746 EKQKKHEVDLEK----QKAT-----------FQEKINK--LQAQVAQEVKMKTQMSVVVEEYEKSISRLLTERERDRTNF 808  Jerdon's jump...
XP_002129482  522 YTEAEMQKLLTDtntpLQNQIDQ-----------------LKATVSKQKEENEQLKVLLQDFEETTSHLETNL-AQEKKE 583  vase tunicate

Q95TU9       1165 ERQLQEVQ-ADRDANYHHLTSLETTFSDLHVKYEKSKEMTSQLKSNEESLLAERKQMMDNLRLQEQRYDKMKNHAMQQLE 1243 fruit fly
XP_010831614  611 KAEMQKVL-KEKAQLTADLHSMEKSFSDLFKRFEKQKEVIEGYRTNEESLKKCVEDYIERVEKEAQKYQALKAQAEEKLR 689  Bison bison b...
XP_005208350  670 KAEMQKvL-KEKAQLTADLHSMEKSFSDLFKRFEKQKE-------NEESLKKCVEdyiERVEkEAQKYQALKAQAEEKLR 741  cattle
XP_003128852  600 RVEVQKAL-QEQEHVSGDLRSVEKSFSELFRRFEKQKEVIEGYRTNEASLKKCVEEYMERLEKEGQRYQALKAHAEEKLQ 678  pig
XP_012915487  637 KAEIQKIL-KEKEQLTADLSSMEKSFSDLFKRFEKQKEVIEGYRKNEELLKKCVEGYIARIEKEGQRYQALKAHAEEKLQ 715  domestic ferret
XP_005045602  682 RKDIQKLM-EEKQQALSDLNSMEKAFSDLFKRFEKQKDALVGYHKNEEVLKKCAEDFWARIKKEEQRYQALKAHAEEKLE 760  collared flyc...
XP_007247623  867 QAELSKVF-QEKQQLAKDLNDMERSFSDVVKRLDRRKEVIDGFKKNEETLKQCAQSYLARLQKEEQRYQMLKTHAEEKIE 945  Mexican tetra
AAH95573      800 KMEMERVL-EEKDQLAKDLNELERSFSSVVKRLDRCKEVIEGFKKNEETLKQYAKNCMDRLQKEEKRYQALKAHAEEKLE 878  zebrafish
XP_011141343  809 EQEKAKLQ-EELQAANHHLTNTEAAFNDVHQKYERLKGVVSVYKNNEAVLKESIQENVDTIKTLETRYDQLKDHAMAQLE 887  Jerdon's jump...
XP_002129482  584 HQEINKVLvNENEQLKSDLESVEKAYFELLQRSKNMKQALSNWKANEATYKNVVEEYKTCIETEQQRYKALKATMEENIK 663  vase tunicate

Q95TU9       1244 IANKKLDTYSREHADETKKLKALLKKEEISRVSMTEQLQQKSRENADLLKICEELI 1299 fruit fly
XP_010831614  690 QASEEIAQVRSKAQTDALALQAVLRKEQMRVHSLEKVVEQKTKENDELTRICDDLI 745  Bison bison bison
XP_005208350  742 QASEEIAQvrsKAQTDALALQAVLRKEQMRVHSLEKVVEQKTKENDELTRICDDLI 797  cattle
XP_003128852  679 LASEEMAQVRSRAQAEVLALQAVLKKEQMRVQSLEKAMEQKTKENDELTRICDDLI 734  pig
XP_012915487  716 LASEEIAQVRSKAQAESLAFQASLRKEQMRIHSLEKTVEQKTKENEELTRICDDLI 771  domestic ferret
XP_005045602  761 QTNETIAQVRSKADAETAALQATLRKEQMRIQSLERSLEQKTKEIDELTKICDDLI 816  collared flycatcher
XP_007247623  946 QANKEIADVRSKLGTEISALQVQLRREQLKVQSLEKNLEQKVKEVEDVTKLCDELI 1001 Mexican tetra
AAH95573      879 QANKAIAEVRTKQGAEVAALQVQLKREQLKVQSLEKDLEQKAKEVKDVTELCDELL 934  zebrafish
XP_011141343  888 KANLELDGIRKQNEAETVKLHAMIRKAELKSNSLAELVEQKTKENKELAKILDEVI 943  Jerdon's jumping ant
XP_002129482  664 RSTEQHRQKEEESQSQLSAVKAKWKFLENQIKSLQSQLDQKVKDNEELTKICDELI 719  vase tunicate
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