5DFZ


Conserved Protein Domain Family
APG6
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pfam04111: APG6 (this model, PSSM-Id:309295 is obsolete and has been replaced by 461178)
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Autophagy protein Apg6
In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway.
Links
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Statistics
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PSSM-Id: 309295
Aligned: 144 rows
Threshold Bit Score: 165.047
Created: 17-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5DFZ_D        181 ICQDCCNILINRLKSEYDDAIKERDTYAQFLSKLESQ---Nk-------------------------------------- 219  Saccharomyces...
A0DRK9         20 YCEKCLQQQMKKEEEEVKQLENEINELQIQLKQVRDEmykM--------------------------------------- 60   Paramecium te...
Q5CPI7        104 LCVDCMNCSISQFSMALNKEISLLDKYKEISDSLISSecyDedqme--------------------------------ds 151  Cryptosporidi...
XP_002177919  102 LCLECIQRVEQALLADTERLKYETKRYDEAVRDERDRqrsLh-------------------------------------- 143  Phaeodactylum...
XP_003291506  777 lCGSCLSRFKTILDEFDQEESLESQMYKNFFLTKQKKqekDeneedeelnqd--------------------ddtdeedl 836  Dictyostelium...
EFA86429      526 LCGPCISTLKEYLERMNQELQRDYTTYTQFIQDHNINikqDnnnndnnnnnsnntnnittfnsnntnkqsftpsihkske 605  Polysphondyli...
XP_002140137   95 VCVECIDKLIMQFELNLNKTIDETKTLNLLIGNIDYSve----------------------------------------- 133  Cryptosporidi...
XP_004027370   37 YCFEC-KQKLEQGTKEIEQLEKQINEIQINLTEINS-------------------------------------------- 71   Ichthyophthir...
XP_012655476   43 LCEPCLKIQLKNEFQDIEIIGQEITETQKKLQLVDENmisIk-------------------------------------- 84   Tetrahymena t...
XP_002670246  104 LCNTCMTDLFGGLSEEIEQLELECKLYDEKLKKSKKFdtnG--------------------------------------- 144  Naegleria gru...

5DFZ_D        220 --EI----------SESNKE----KQyshnlsekeN-----------LK-----KEEERLLDQLLRLEMTD----DDLDG 263  Saccharomyces...
A0DRK9         61 --ET----------NQIEKK----ND---------K-----------IE-----LDKKNLDKEIYQLEQDE----QQQKK 95   Paramecium te...
Q5CPI7        152 evNF----------EPTSKEyleiMN---------Iyn-------efIKmeqynQEKTIINDENDNDEIDCtetdKDIKE 205  Cryptosporidi...
XP_002177919  144 --QAlnavsfaglgDNFQPE----FM---------SqsadadsssplLQ-----RAEEAFRNEIEALQQCC----DQQED 199  Phaeodactylum...
XP_003291506  837 knEL----------LNIEKE----IN---------D-----------LE-----KEEKELIQEYLELENQN----QINLD 873  Dictyostelium...
EFA86429      606 weDL----------SNLSNEe---LD---------Aqi-------klIE-----LEEIELMNEYLQLERNN----NDVID 647  Polysphondyli...
XP_002140137  134 -----------------------dIS---------Iid-------slIK--------DSLFDNEKDLPDKCnf-nQCIHD 165  Cryptosporidi...
XP_004027370   72 --KI----------SHVTHE----IN---------Lik-------tsEQ-----KNETEIEQEYKQLEQEE----EELNQ 110  Ichthyophthir...
XP_012655476   85 -nKI----------EENEKL----IN---------Q------------------SQQQKQKLEIEELKMKE----QQLNQ 118  Tetrahymena t...
XP_002670246  145 --MY----------KKYMKE----MD---------E-----------LR-----NEELVLREQVNVIQNDR----HRIGR 179  Naegleria gru...

5DFZ_D        264 ELVRL-----QEKK--V-------QLENEKLQKLSDQNL-MDLNNIQFNKNLQSLKLQYELSLNQL-DKLRKINIFNATF 327  Saccharomyces...
A0DRK9         96 ELIKL-----KNSI--L-------EQEHNEDNLWEHINK-FTRKLYSLFESNQIADNKLSQLNNEL-DRLSKLDVLNDLF 159  Paramecium te...
Q5CPI7        206 GYGKC-----RFQV--IntievddIVELRQNQNLESN---LKHELIQYELKREGMKNHLDFLRGYL-ERLKRSDFLNLSF 274  Cryptosporidi...
XP_002177919  200 EIGHLrslvkEQELikQ-------ELQATELLVAAERNS-LEVEARAFDNDHEQLCDHLLSIQKEV-ETLSSSQIRWPAF 270  Phaeodactylum...
XP_003291506  874 IKIKL-----EDIL--K-------EIKQEEKTHYDSVNN-YYQEYYDLKQEDEIWDNYISSIKDQI-ERVTQIDIKKAFF 937  Dictyostelium...
EFA86429      648 IRNKL-----EDIR--G-------EIKSEEKQHYNNVNH-FYQEYFNLLGQKKSLESQIATMKDDL-DSLSDLNIVKEVF 711  Polysphondyli...
XP_002140137  166 NLDYF-----EI------------LVKRQEKEI--RLNNiFKLEYIQRL--IDGTNSDIKFLQYHV-DLLRKINIFNTTF 223  Cryptosporidi...
XP_004027370  111 KIFEL-----KEKI--L-------TYEQQENEYWDEVNI-FEKNLYQVLEKKQIAENQEKHYNEQL-IKLNTYNTLNQVF 174  Ichthyophthir...
XP_012655476  119 EFEKL-----KKNV--L-------DFEIRESKYWVEVNS-FEKRLQTLLNKKQIADNLEQYYNDKLnNKLNKYNTINSVF 183  Tetrahymena t...
XP_002670246  180 NITSL-----QTEY--N-------TQQESEKNYWKIYFQ--FIHNNQFLAEENRRKSQLIDKEDKI----RRKSPLAGMF 239  Naegleria gru...

5DFZ_D        328 ----KIs---hS--G-PFATINGLRLGSIPESVVPWKEINAALGQLILLLATINKNLKIn-lVDYELQP-MGSFSKIk-- 393  Saccharomyces...
A0DRK9        160 ----KI-----SvqD-EVATINGLQIGKKGEQPVDWDDISAGVGHLTLLLVYLMKKFMYt-yQKIESIElNGSFSKIkik 228  Paramecium te...
Q5CPI7        275 ----YI-----QviE-GGACINGLRPALFEADFDNWNEVNAALGVSAMLLYTILERHKL----PLSIYP-NGSYSTI--- 336  Cryptosporidi...
XP_002177919  271 fldvRId---tR--GlRYPLINDLRLAYRAKGDLSWNEIQTAWSLAAQLLLIVGTIFEFa-sQEWKIVP-LSHCAKLi-- 341  Phaeodactylum...
XP_003291506  938 ----KIag-seDsnG--IASINGFRLGTLQNLKVDWDEINSAWGETSLLLHVLATQLEYn-fLNFKLIP-MGNKSIIq-- 1006 Dictyostelium...
EFA86429      712 ----QItfekiDehT--IVKINDLRLGTLPKNKVEWDEINGAMGQIVLLVHTIAKQLNYt-fTKHKLIP-MGNKPLIq-- 781  Polysphondyli...
XP_002140137  224 ----YI-----NqiN-GIGTINNLRLGLLDNSDENWREINGALGYTSLLLCCIAEKLNI----EVTLNP-YGNYSTItdr 288  Cryptosporidi...
XP_004027370  175 ----NI-----QcdE-QAGTINNIIIGKKLNQEIVWDETNAGLGQIAMLFSYLVKKYGYe-mKFIKDINlCANESQIc-- 241  Ichthyophthir...
XP_012655476  184 ----FI-----EvsE-QVGLINNLMIGKKLNEDINWDETNAGLGQVILLFLYLMNKFGYq-sSYIKDIQvCGNESYIc-- 250  Tetrahymena t...
XP_002670246  240 ----HLw---yE--G-SYGTINGLRMGRLRHDPVSWEEINAAWGLAVLLLDLTAQQLNNfkfTKYKLVP-KASCSSIk-- 306  Naegleria gru...

5DFZ_D        394 -KrmvnsveY----NnsttnapgdwliLPVYYD-ENFnlgr---ifrK--------------ETKFDKSLE-TTLEIISE 449  Saccharomyces...
A0DRK9        229 dEyqntlctK----T------------LNLYLNnKTSq--------kD--------------EEEFSDAFL-QLYFEFQQ 269  Paramecium te...
Q5CPI7        337 ---------K----Dses-------siWPLHGNtLCNsd------ynE--------------CTNFDKGIL-SFVFLIDT 375  Cryptosporidi...
XP_002177919  342 -Q-------YpggkKqpp-------tvYNIGCS-GKQts------laLlawnallheiikdtSEKLNQAHKdGLLDL--- 396  Phaeodactylum...
XP_003291506 1007 -S-------K----Ndk--------vsYSLYGGdNIQfsrsflwfgaS--------------DQRFDNGME-AFLSCVNE 1051 Dictyostelium...
EFA86429      782 -S-------K----Sdk--------eaYPLYGGdDIYfrsf---iwsR--------------EHKFDIGME-AFLGCINE 823  Polysphondyli...
XP_002140137  289 cIpeylsnfV----Keey-------siLPLYGNtSANsn------ynQ--------------CIKFDSAIK-ALLSNISN 336  Cryptosporidi...
XP_004027370  242 --------eI----Ekn--------qiLQLYGPlNYQs---------E--------------YSRFDQAIK-LLLKEFYC 277  Ichthyophthir...
XP_012655476  251 --------eA----Nks--------eqLYLRGPfSNKg---------D--------------EAKFNRAMK-MILDEFSL 286  Tetrahymena t...
XP_002670246  307 -E-------L----Esg--------dkYDLFFSsTR-----------N--------------IQSFNEGMK-CFLFCLEE 340  Naegleria gru...

5DFZ_D        450 ItrqlstiassyssqtlatsqdessmnnANDV---EN-----STSilELPYIMn-------kD--KING----LS-VKLh 507  Saccharomyces...
A0DRK9        270 F---------------------------CKYLqdgDIlrkrkINL--NLPFTM---------NgmSVDNk--iLS-LKQp 308  Paramecium te...
Q5CPI7        376 V---------------------------YNIIpgtNE----------TLPYSVd-------qRngTIGG----IS-LNLl 406  Cryptosporidi...
XP_002177919  397 -------------------------------------------SVlpPLPFAM---------AktTIGD----LNlLRLs 420  Phaeodactylum...
XP_003291506 1052 I---------------------------SSFVltkKNi---------NFNYRI---------NkdKIGDsnrfYS-IKIa 1085 Dictyostelium...
EFA86429      824 M---------------------------CSLFkn------------vVFPFKI---------EkdKIGGnngfQS-IRVt 854  Polysphondyli...
XP_002140137  337 I---------------------------AKYMncsD-----------KLPFIIn-------yDmnTIDG----VS-YNLl 366  Cryptosporidi...
XP_004027370  278 F---------------------------YEFLinqVKigdyvEEV--KLPYNId-------iQkcEIDY----VE-ISIm 316  Ichthyophthir...
XP_012655476  287 F---------------------------VDYLqqtYLqn-------iQLPFKId-------qSnsSIDGl--lLT-TQTa 322  Tetrahymena t...
XP_002670246  341 L---------------------------CQHIg-------------iVVPGSSigtrlivkaDegKIQDlsmlYS-VER- 378  Naegleria gru...

5DFZ_D        508 gsspN---LEWTTAMKFLLTNVKWLLAFS 533  Saccharomyces cerevisiae S288c
A0DRK9        309 aaqkW---QEWTNSVKKFLANVKALIVAN 334  Paramecium tetraurelia
Q5CPI7        407 fn----erESWNRAMSMNLINLKWLLVRS 431  Cryptosporidium parvum
XP_002177919  421 p-edD---VRWSQAIQYTATNLQWLSVCT 445  Phaeodactylum tricornutum CCAP 1055/1
XP_003291506 1086 s-nsE---AHWTSALKFMLSTLKKILDNL 1110 Dictyostelium purpureum
EFA86429      855 g-nsE---VNWTKALKYMVTNIKCILTNL 879  Polysphondylium pallidum PN500
XP_002140137  367 f-ndK---QTWNNAMKMLLINLKYLIINL 391  Cryptosporidium muris RN66
XP_004027370  317 k-----niDLWTSGMKKFLINFKYIIYIN 340  Ichthyophthirius multifiliis
XP_012655476  323 anaqYkglDNWTQAFKKLLINFKFLISFN 351  Tetrahymena thermophila SB210
XP_002670246  379 ----E---YEWTKALKYLIINLKFVQKNV 400  Naegleria gruberi strain NEG-M
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