1ZY7


Conserved Protein Domain Family
A_deamin
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pfam02137: A_deamin (this model, PSSM-Id:307992 is obsolete and has been replaced by 460458)
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Adenosine-deaminase (editase) domain
Adenosine deaminases acting on RNA (ADARs) can deaminate adenosine to form inosine. In long double-stranded RNA, this process is non-specific; it occurs site-specifically in RNA transcripts. The former is important in defense against viruses, whereas the latter may affect splicing or untranslated regions. They are primarily nuclear proteins, but a longer isoform of ADAR1 is found predominantly in the cytoplasm. ADARs are derived from the Tad1-like tRNA deaminases that are present across eukaryotes. These in turn belong to the nucleotide/nucleic acid deaminase superfamily and are characterized by a distinct insert between the two conserved cysteines that are involved in binding zinc.
Links
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Statistics
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PSSM-Id: 307992
Aligned: 93 rows
Threshold Bit Score: 300.279
Created: 15-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1ZY7_A        72 SVSTGTKCINGEYMS-----DRGLALNDCHAEIISRRSLLRFLYTQLELYLnn-----------kdDQKRSIF-Q-KSE- 132 human
XP_014628914  60 AMGTGTKCLGRSLLR-----TCGDVVHDSHAEVIARRALIRFFYTQIQHLTgskhapsnggkrfklDDGNSPF-ElDPG- 132 soybean
XP_006345596  64 SLGTGTKCIGRSRRS-----SKGDVVNDSHAEIIARRALLRYLYSEIQDVYnthahsn--gsvlrdDVENFMF-HlESD- 134 potato
XP_009395421  69 ALGTGTKCIGGSLLS-----PTGDVVNDSHAEIIARRSLLRYFYAEIERLDrihqtsr--ddvgfaDASKSAF-GlDTS- 139 wild Malaysian ...
OAP13904      63 ALGTGTKCVSGSLLS-----PRGDIVNDSHAEVVARRALIRFFYSEIQRMQltsgksneakrqridSETSSIL-EsADSs 136 thale cress
XP_002987088  51 ALGTGTKCLGGSQRS-----LAGDTINDCHAEVIARRTLLKLLYTDIGSFVde------------gQDSRSKF-FkRDD- 111 Selaginella moe...
EGI59195      49 ALATGTKCLGDSELSkgsreEKGSRLSDSHAEVLTRRAFIRYLYDQIDLTLn--------------DSGSAIF-SrNDK- 112 Panamanian leaf...
XP_008205328  49 SLCTGTKCLSGVELRstkcnERGNKLSDSHAEILARRAFLRYLYHQIELAIs--------------NQKSDIFyLeDNG- 113 jewel wasp
EFX79359      61 SMGTGSKCVGQNKLS-----KDGDILNDSHAEVVARRGFLRYMYHQMEIAAs--------------GKESGLF-TvDAI- 119 common water flea
XP_003389594  63 SLGTGSKCIGEHKMS-----LEGWLVNDSHAEIIARRGFVKYLIGQLKSAIl--------------ETEDTIF-ErSPIc 122 Amphimedon quee...

1ZY7_A       133 Rg---gFRLKENVQFHLYISTSPCGDAR--------I---FSPHE----PIle--------------------------- 167 human
XP_014628914 133 ClnkgkYSLKKDWKLHMYISQLPCGDAS--------LswqVSPLE----TAvl--------------------------- 173 soybean
XP_006345596 135 GlgtkkLKMKHGWQLHLYISQLPCGVASpg----seL---ALLHD----SPak--------------------------- 176 potato
XP_009395421 140 CcgqtkYRMNPGWGLHLYITQLPCGVFSyptlqpreL---PVQTD----LSak--------------------------- 185 wild Malaysian ...
OAP13904     137 CpgevkYKLKSGCLLHLYISQLPCGYAS--------T---SSPLY----A------------------------------ 171 thale cress
XP_002987088 112 Ng---rLRMRPEIRLHLYISQSPCGDAC--------I---LGVDPg---------------------------------- 143 Selaginella moe...
EGI59195     113 Nk----IELNSNISFHFFSSQTPCGDCS--------I---FPKLEtngpSPckirrv----------------------- 154 Panamanian leaf...
XP_008205328 114 ------IKLR-DVSFHFFSSQTPCGDCS--------I---IPKLTgeteDLvcppkk----------------------- 152 jewel wasp
EFX79359     120 Sk---kFLQREGVSFIFFSSHTPCGDAS--------I---IVKENs---RImcnttegilkp------------------ 164 common water flea
XP_003389594 123 Kg---qYSIKNGikfhfftsqspcGDAS--------I---FPLST----KHqrieeeegeengsatkrmklieeesgsit 184 Amphimedon quee...

1ZY7_A       168 ----------------------------------------------------epADr------------hPN---RKARG 180 human
XP_014628914 174 ----------------------------------------------------geSDs------------tS--------- 180 soybean
XP_006345596 177 ----------------------------------------------------ngDMm------------cSSmqlSYSKG 192 potato
XP_009395421 186 ----------------------------------------------------igGSs------------eSN---GFQNG 198 wild Malaysian ...
OAP13904     172 ------------------------------------------------------LKkipst-----qvddSL---LVQAS 189 thale cress
XP_002987088 144 ----------------------------------------------------------------------AG---EDDHS 150 Selaginella moe...
EGI59195     155 -------------------------------------------------nkdanEHgive-------syyKD---VHRTG 175 Panamanian leaf...
XP_008205328 153 -------------------------------------------------artedESlasqf-----gqaiVD---IYRTG 175 jewel wasp
EFX79359     165 --------------------------------------------seikvtsfdeEPpskmp-----rfdiPD---IHRTG 192 common water flea
XP_003389594 185 egnpnqfpirstsapkstvtvstgqavdrelnavedgahsdvhrtgtkclitstGQaideevnavedgahSD---VHRTG 261 Amphimedon quee...

1ZY7_A       181 QLRTKIES-G--E-GT---IPVRS---N--A-S-IQTWDGvlQGERLLTMSCSDKIARWNVVGIQG-SLLSIFV-EPIYF 244 human
XP_014628914 181 ----PLGN-G--L-KQ---KGM------------VQRKPS--RGDTTLSVSCSDKIARWSVAGVQGvALLSYFL-QPVYL 234 soybean
XP_006345596 193 ESSGYTAM-N--D-GC---LPIPF---G--T---VMRKPG--RGDTTLSVSCSDKIARWNVVGVQG-ALLSYFL-EPIYI 253 potato
XP_009395421 199 KSQIK-ES-D--H------FPSDYpqiS--T-I-VQRKPG--RGDTTYSMSCFNKITRWNVVGVQG-ALLFHIL-QPVYL 260 wild Malaysian ...
OAP13904     190 DICSSRHS-DvpEiGSnsnKGNGS---Q--VaDmVQRKPG--RGETTLSVSCSDKIARWNVLGVQG-ALLYQVL-QPVYI 259 thale cress
XP_002987088 151 EFCCTTGA-KlvS-TQ---VHSEQ---SlqTtGmLRRKPG--RGDATFSMSCSDKIARWNVLGVQG-ALLSLFLnEPVYI 219 Selaginella moe...
EGI59195     176 AKCVKGEGaQ--DpHL---PGADY---H--IvGpLRTKPG--RGDPTSSLSCSDKIAKWLVLGLQG-SLLSLLI-PPIKL 241 Panamanian leaf...
XP_008205328 176 AKCVDSDErQ--DpHE---KGINY---H--TvGpLRTKPG--RGDRTLSLSCSDKLAKWNVMGVQG-ALLSLMI-PTIKF 241 jewel wasp
EFX79359     193 AKCVEGGP-Q--DlKQ---PGVNH---H--VaGvLRIKPG--RGDRTLSMSCSDKLAKWNILGVQG-SLLMNFLsKPIYV 258 common water flea
XP_003389594 262 AKCVKGGS-T--DsHL---PGLGY---H--VlRaLRTKPG--RGDPTLSMSCSDKMMRWNVLGVQG-ALLFLLIdKPVYL 327 Amphimedon quee...

1ZY7_A       245 SSI-ILG--SLYH-------G-------DHLS-----------RAMYQRi----sN-IEDLPPLYTLNKPLL-----SGI 286 human
XP_014628914 235 SSI-TVG--LPLD-------IlenfrleDSLK-----------RALYERm----lPlSNELTSPFLVNQPIF-----HAA 284 soybean
XP_006345596 254 FSV-TIG-------------Q-------SHLAsktsiiedevmRAIHERv----lPlSNKLMDPFRVNKPLV-----FVA 303 potato
XP_009395421 261 STL-TVGf-SPCDglqksvkT-------NYLE-----------KAIYDCm----eRlHIKLTKPFHLNKPCI-----IEA 311 wild Malaysian ...
OAP13904     260 STI-TVGq-SLHS-------Pdnf-slaDHLR-----------RSLYERi----lPlSDELLTSFRLNKPLF-----FVA 309 thale cress
XP_002987088 220 STItVARstKASP-------LvsdlaciEALQ-----------RATFGRl----cSvARNLEAPYRLNQPVI-----WLA 272 Selaginella moe...
EGI59195     242 ESI-TIGgdSPFS-------L-------DAME-----------RGLYKR---------------FNNKLVSVnifqtKTA 280 Panamanian leaf...
XP_008205328 242 ESI-VIGggCPYS-------L-------ESMQ-----------RGIFQR------------FDP-NIGAPEIvq--sQIS 280 jewel wasp
EFX79359     259 SHV-IIGk-CPYS-------Q-------SVME-----------RALINRfehsanQlGNAV---FMQQKPDIsqsqiELK 308 common water flea
XP_003389594 328 HSItVSG--ELYN-------Q-------EAME-----------RALVGRlch-lkLsKELLEKGYKLHQPIIkqlkqGSL 379 Amphimedon quee...

1ZY7_A       287 SNA-------Ea--------RQ-------PGKAPNFSVNWTVGDSAIEVINAtTGKDELGr---------aSRL--CKHA 333 human
XP_014628914 285 PVPpkdfqqsEs-------aAN-------TLTCG-YSICWNECGL-HDVIMGtTGRKQGTsakgalypstqSSL--CKKR 346 soybean
XP_006345596 304 PIP-------Se-------eFQhsetaltTLTCG-YSICWNNSGL-HEVILGtTGRKQGTsakgamspsteSSL--CKKR 365 potato
XP_009395421 312 PIP-------AdrlqqsngdET-------NLTCG-YSICWNKSGL-YEVVLGtTGRKQGTsakgalspsteSSL--CKRR 373 wild Malaysian ...
OAP13904     310 PVP-------PsefqhsetaQA-------TLTCG-YSLCWNYSGL-HEVILGtTGRKQGTsakgalypstqSSI--CKQR 371 thale cress
XP_002987088 273 PTP-------Pedy----mlYP-------SGLACGYSISWDSSGS-HEVVIGtTGRKQGAagkgallpateSKL--NRKS 331 Selaginella moe...
EGI59195     281 FMH-------Kkg------qQR-------SDSCP-ISIIWCAVKNSALEIAV-AGRKQGItkkrk---gnnlLI--TRRM 333 Panamanian leaf...
XP_008205328 281 FEH-------Rkn------eSR-------TRPCP-SSIVWCLVPEKPIEIAV-DGLRQGAtkkkn--ksfnLLI--SRKE 334 jewel wasp
EFX79359     309 FGK-------Vend----edDQ-------MHPCP-SSISWCACPMKQLEVAV-EGRKQGItkknqnkpqcrLEI--CKKN 366 common water flea
XP_003389594 380 QEL-------Tk-------gGT-------RCRMAPGSIVWCIDPPTHEVII--QGYCQGAnrkqk--pddkSSVsiCKKK 434 Amphimedon quee...

1ZY7_A       334 LYCRWMRVHgkvpsHLL-RSKIT--KPN----------VYHESKLAAKEYQAAKARLFTafikAGLGAWVEKP 393 human
XP_014628914 347 LLEVFLSLG-----PENlIGSLP--NGI----------TYRELKDGAEEYHLASKIFKr---kASFNKWFLKP 399 soybean
XP_006345596 366 FLESFLSLS-----HNCvGEHAF--VGN----------SYRELKDKSQEYNLASETFKGs---SNFKNWFLKP 418 potato
XP_009395421 374 LLEVFVSLQ-----SRLsLQLQS--AEI----------SYHGLKAMAHEYQSSLKMLRe---sPAFSSWHLKP 426 wild Malaysian banana
OAP13904     372 LLELFLKETh----GHK-RESSK--SKK----------SYRELKNKATEYYLMSKIFKGk---YPFNNWLRKP 424 thale cress
XP_002987088 332 LGRSFRHLLt----HFF-PGLAC--S------------NYLECKKLALTYLEAKEILLHl--nSPFAGWLSNT 383 Selaginella moellendor...
EGI59195     334 LLQSFLQIFdkyqnYYS-EIRHP--KKI----------TYYDWKQWSIIYQNEWKQLKHe----lFHNWPCKS 389 Panamanian leafcutter ant
XP_008205328 335 IFKTFLTIYd----KFL-KGKLIpqHPKk--------iTYYHCKQYSSSYQNLWREk-----sAVFSKWPTKP 389 jewel wasp
EFX79359     367 LFQKFVSLLs----CFP-TDNLP--IHLkeqhsdiqcmTYNKAKRLCSDYFEMWEQTRA----KMLSTWTSKP 428 common water flea
XP_003389594 435 LFSDFKELVq----LIS-DNDLP--VILsdlrvqeyegRYYDWKQSSLDYQKARTLFN-----EHFPTWLTNG 495 Amphimedon queenslandica
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