Conserved Protein Domain Family
EMP24_GP25L
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pfam01105: EMP24_GP25L (this model, PSSM-Id:307313 is obsolete and has been replaced by 426051)
emp24/gp25L/p24 family/GOLD
Members of this family are implicated in bringing cargo forward from the ER and binding to coat proteins by their cytoplasmic domains. This domain corresponds closely to the beta-strand rich GOLD domain described in. The GOLD domain is always found combined with lipid- or membrane-association domains.
Links
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Statistics
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PSSM-Id: 307313
Aligned: 215 rows
Threshold Bit Score: 43.4434
Created: 13-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q38AU2        32 AARFLLQNTQPICFVEEVgedTRFLTGVYTRSdslpyP----PTVKMT--IK--SPSGsVTWEGKVVAGTnsFSAPVSA- 102 Trypanosoma brucei
A0CNR3         2 QFGYEVDKGQQICFQDYFs-qNDVFDLKIRAN-----Ts--nYAVKLE------EAVAkRYAILYEKSGSweHNYQHQSs 67  Paramecium tetr...
A0CKN2        14 QFGYEVERGQSICFEDYFs-qDDVFDLRVRAN-----Ss--nYSVKLE------ESEQkKYVPLYERSGAweHNYQHQSn 79  Paramecium tetr...
A0DT41        16 ILKFKVPPGQQQCIKDSVs-qNTLIYGNYDTT-----Sl--hYSFTLS--IInqQDQEsIIIQHANDINQ---QFHYVM- 81  Paramecium tetr...
A0CX19        16 SLKFKIPPGHQQCIKDNVa-qNTLIYGQYESS-----Tl--lYIFTLN--VInqQEIEnTIIEYSSQAVS---QFHHVM- 81  Paramecium tetr...
A0CWC1        14 EFNQSLGKREITCFGDSLt-eGLTVIGEISST-----Ik--dFSIKIYnpMR--FKKEgYLHQSQNELIQ---QFKFKV- 79  Paramecium tetr...
A0D933        16 QFTFPLRSKELKCFGEIIg-qNSLVVGSVQAN-----Ss--eYSLKIH--IP--QKKAdSILQYSHSLELn--KFSFTTn 81  Paramecium tetr...
A0CJE7        16 QFTFSLKQKELKCFGENIg-qNSLVVGAIQGN-----Ss--eYSLKIH--MP--TKKVdNILQYTHSQELh--KFSFTTn 81  Paramecium tetr...
XP_001025950  25 ELAIKLEGRQEHCFFDSL---GERILVRLTIVc----Dk--gEFLEFK--VS--NQDGtYSETQAELKTQ---NFQIIT- 87  Tetrahymena the...
EDK40444      36 SSKSQLSN----CVAYDTv-kNDVITVHVQAY-----DrvpaQQLNLH--IFdsENNQlRLVKD-INDEM---DVIFTN- 98  Meyerozyma guil...

Q38AU2       103 G-----------------------------------SIGKYQICVSVSTWGFRAsddgssvvMDVNIDQKT---TVISKt 144 Trypanosoma brucei
A0CNR3        68 H-----------------------------------KTSHLKYCFINLEDEI----------VLFNVTYKTg--SELAD- 99  Paramecium tetr...
A0CKN2        80 H-----------------------------------KTSHMKYCFINLENDG----------ILFNITYKTg--SELAD- 111 Paramecium tetr...
A0DT41        82 E-----------------------------------ESGEISMCFEVEDYADV---------TIFNLFYESg--AEIYD- 114 Paramecium tetr...
A0CX19        82 Q-----------------------------------ESGEISMCFEVDDYSDI---------ATFHLFYESg--AEIYD- 114 Paramecium tetr...
A0CWC1        80 K-----------------------------------YNHNIQICIQNLST------------STILYSLKYsqdNEEQS- 111 Paramecium tetr...
A0D933        82 N-----------------------------------TQENYQFCVHNLANAG----------INFNFSLATg--MDAQD- 113 Paramecium tetr...
A0CJE7        82 N-----------------------------------TQLNYQFCIHNLANDW----------TSYNFTLVTg--MDAQD- 113 Paramecium tetr...
XP_001025950  88 E-----------------------------------FEGEYQFCFHNTDLKED---------LTVYFDYKTg--VEAKD- 120 Tetrahymena the...
EDK40444      99 LnsdlgrgkrssfidklshlghadsehaeevlhsneGKSRIYVCFDNIFADKSWsfh--pqsRDIELQFEAr--SFASLk 174 Meyerozyma guil...

Q38AU2       145 evpmlkrq-----nvggmevftFRDfggqqkDILrpPEYFKRVEGALSKLLMQVKDVSSGIDHNIERFSRMFTTSENTHK 219 Trypanosoma brucei
A0CNR3       100 ----------------------MQK------VAK--ISDLNQMGDNMKKLNGLLDDIKRERSFLISKYDYMDKMQGSISK 149 Paramecium tetr...
A0CKN2       112 ----------------------MQK------VAK--ISDLNQMGGHMKKLNSMLDDIKRERSFLIAKYDFLSRMQGSISK 161 Paramecium tetr...
A0DT41       115 ----------------------QDL------LAK--KQHVLNLNETLETMEQLQQDISREQLLIVDRENKRKHSFTDIQT 164 Paramecium tetr...
A0CX19       115 ----------------------QDQ------LPK--KQHVQNINETLEQMEQLQQEISREQLLIVDREHIRKISFVDFQQ 164 Paramecium tetr...
A0CWC1       112 ----------------------QKI------DTQlpMTQLQPVENLMAQMKISYDIIKGMFSSLSERQDQRLQQLQQLGY 163 Paramecium tetr...
A0D933       114 ----------------------FSL------VAQ--KEDLKPIEIHLKKLNGLINSVEHEQKEIEERQATRFSNVSKISY 163 Paramecium tetr...
A0CJE7       114 ----------------------FSL------LAQ--KEDLKPLEIHLKKLNGLVNAVELDQKEIEERQSNRFQNVSKISY 163 Paramecium tetr...
XP_001025950 121 ----------------------YAD------LIK--KEDGVKFELSAKRLEDTLKDISLEKRFIYRHQQYNSALQNDLTF 170 Tetrahymena the...
EDK40444     175 ntnyklftkyfqmlgsesgsnvIKD------SDF--EDSLVTLESQLQTVIENLDSSERTMQALLTQESKLRDANEQIFS 246 Meyerozyma guil...

Q38AU2       220 RIWAFGVLTVLVTIATIWLQFRLLKSTLR 248 Trypanosoma brucei
A0CNR3       150 KQVVFGLLCLGLSFIITAITLNLIKRILQ 178 Paramecium tetraurelia
A0CKN2       162 KQIVFGLMCLGISLIITAITVNLIKRILQ 190 Paramecium tetraurelia
A0DT41       165 KIIGFAGITFGLLIIVGACQVIYVRRFIV 193 Paramecium tetraurelia
A0CX19       165 QIVEFTAITLSILIIVAVLQAIYIRRYAK 193 Paramecium tetraurelia
A0CWC1       164 RIVISSIVLLLVTVLITVFGTYRYKKVMK 192 Paramecium tetraurelia
A0D933       164 KIIIFSIVTLILMSLTNFVQARQLKNFFK 192 Paramecium tetraurelia
A0CJE7       164 KIILFSVITLLLMMLTNFVQARKLKQFFR 192 Paramecium tetraurelia
XP_001025950 171 KIQGFSIITLVLLIALAIFQSYYLRQFFK 199 Tetrahymena thermophila SB210
EDK40444     247 NYTKVSIAFLIIIAIFGLLPIVYMRVYLK 275 Meyerozyma guilliermondii ATCC 6260
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