3HZJ


Conserved Protein Domain Family
RabGAP-TBC
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pfam00566: RabGAP-TBC (this model, PSSM-Id:306939 is obsolete and has been replaced by 459855)
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Rab-GTPase-TBC domain
Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.
Links
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Statistics
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PSSM-Id: 306939
Aligned: 73 rows
Threshold Bit Score: 74.9911
Created: 12-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3HZJ_A        36 EALRAEVWQLLAgchdnqaxldry-------------------------rilitkdsaqeSVIT-RDIHRTFP----AH- 84  human
A0BI92       170 EDFNL--WQTIEndtkrtrqregffhienqe-----------aslfedvkklyiqdqvaiLRLKrVDIEYNYD------- 229 Paramecium tetr...
O94661        38 KSLRKSVWVSLCglscrhrmecls-------------------------rstsqssyadqNQVH-LDSERSFFq--yKL- 88  Schizosaccharom...
Q7S8L1        61 DELRQQAWPILLglppkpfdedssss--------------------syssweslpphqdeDQVQ-LDVDRSFTyypsHT- 118 Neurospora crassa
Q6CII2        36 QRTRSHVWSILSraslekctqeylr-----------------------lvqlgappsnwiSKIK-NDTFRTLS----TD- 86  Kluyveromyces l...
Q18386       450 PTQRADVWCTLLdinetkwrdyl--------------------------nldvlashssdRQLE-VDIPRCHQ----YD- 497 Caenorhabditis ...
XP_001309419 244 TDLRPLLWPQLLgvlpfakeiesvldqrvdeyklv---kyqwesmssfqlthrpelrsayQTIR-MDVKRTHL-----P- 313 Trichomonas vag...
XP_001307913 123 EESRWFVWLYLLgiydpnksydeniasitnnnyiyesirkswnnipkiqmnetssisklaNDVM-KDVKRTDRn--lEQ- 198 Trichomonas vag...
XP_012814266 389 pSLRGEVWPFLLgyypweitsedrealrvhrreey--sqiqkkrvsmsptaqkefwknvqFTVD-KDVVRTDRs---NQf 462 western clawed ...
XP_002041664  34 eALRPDVWQVCLdvrhksdqmsl---------------------------fneiydlpfqSQLR-EDCQRHVDr--mGN- 82  Drosophila sech...

3HZJ_A        85 DYfKDtgGDGQESLYKICKAYSVYDE---DIG-------YC--QGQSFLAAVLL--------------L-HX-PEEq--- 133 human
A0BI92       230 ------------VLTRILFIYTKLNG---Q---------YI--QGMNELVAILYyc-----------fVnDD-STLlrsq 271 Paramecium tetr...
O94661        89 NPfLL--RKHRSQLTKLLSVVFKHYP---ELC-------YY--QGLHDIAQILLl---------------TL-PFSh--- 135 Schizosaccharom...
Q7S8L1       119 SDsAR--SLQKSLLSSLILSVLRRHP---YLH-------YF--QGYHDISQVLLl---------------VL-PAHl--- 165 Neurospora crassa
Q6CII2        87 EKfRN--KVTESQLIRVLSCFAWDVLdsnQTHelpglspYV--QGMNVLLAPFLy---------------VC-PTEp--- 143 Kluyveromyces l...
Q18386       498 SYmTT--PAIQESLRKVLKGWQIVTEs-qHFV-------YW--QGCDSLATPFL--------------LaNMsKPHv--- 548 Caenorhabditis ...
XP_001309419 314 EGsNE--QAIKPMMENILKTYAIWNY---DVR-------YT--QGINDVVLPFLl------------vFyNS-KLYtddq 366 Trichomonas vag...
XP_001307913 199 FSrDD--HPNLSVLNNVLVSYAMYCK---DTG-------FV--QGMGDIVSLFIilyikswdnektcnLvDG-RKVdket 263 Trichomonas vag...
XP_012814266 463 FRgED--NPNVESMRRILLNYAVYSP---GVG-------YS--QGMSDLVAPIL--------------AeVL-DESd--- 510 western clawed ...
XP_002041664  83 DEeDK--VSVVSDLESIITFYCKNRN----LQ-------YEpdNGWIELLLPLF--------------AlKL-NRSd--- 131 Drosophila sech...

3HZJ_A       134 ----AFCVLVKIXydYGLRDLYRNNF----ED--LHCKFY---QLERLXQEQLPDLHSHFSD---LNLEAHX-YASQWFL 196 human
A0BI92       272 aevdTFFCFTILL--SQFRYNFFSKDeasiCNgfIQNKIR---VVQEIIKKHDFRLYDHMLK---IKIDPKL-FMSKWFM 342 Paramecium tetr...
O94661       136 ----ALPLMEHLVf-YRLRDFMLPT---------LDGTVKqlqLILAVIKARDPTLYEYL-----IKADIQCyFALSWLI 196 Schizosaccharom...
Q7S8L1       166 ----RSPALARLSa-LRIRDFMLPN---------LQAAIAqlrLIPDILRVSDPPLWRHL-------SGTEPfFALSGTI 224 Neurospora crassa
Q6CII2       144 ---iAYKLFHSLCf-QMIPTYLNQSL----SGvhVAAK-----LLDKCLKIIDPKLSKFLTD---NLLTAEI-FGIPSIL 206 Kluyveromyces l...
Q18386       549 ----AFACFKEFTy-RYCHKFYLKDN----SEv-IKEYLG---IFYHLVAYTDPVLYKHLKI---NGFDAEL-FAIPWFL 611 Caenorhabditis ...
XP_001309419 367 vealGFWCFASFA--EKINSSLIEGS----MDgvTNIDLQ---LVIELLGTHDPKVKEWIIK---SDMQDMN-FVVSSFM 433 Trichomonas vag...
XP_001307913 264 aenfIFQILCKMMt-ITQQDRMFTDL--------LKQQEFafeRVFDIIKDFHPNLAEWLQN---NQLQNLI-FLYRHII 330 Trichomonas vag...
XP_012814266 511 ----TFWCFVGLM----QNTIFISSP----RDedMEKQLL---YLRELLRLVHPRFYQHLYSlgeDGL-QML-FCHRWIL 573 western clawed ...
XP_002041664 132 ----TFNLFESIRd-TYIPKGCRPK----------GNVFH---VFRLLLLYHDPELCTLLDT---KKITPDL-YSLTWFQ 189 Drosophila sech...

3HZJ_A       197 TLFTAKFPL-CXVFHIIDlLLCEGl---NiIFH-VALA-LL-KTSKEDLL 239 human
A0BI92       343 TVFTKEFKL-YDTIILWD-HILcelddkNeLLNyIALA-II-HWLREDLL 388 Paramecium tetraurelia
O94661       197 TWFAHDVSDiSVVCRLFD-FFIs----sHpLTV-VYTCaQVvLDNRTSII 240 Schizosaccharomyces pombe 972h-
Q7S8L1       225 TMYAHDITTlGEITRLFD-VLLa----rEpVFS-VYMFaAIvRSRREELF 268 Neurospora crassa
Q6CII2       207 TLSACNKPL-DQVIKLWD-FMFayg-fhMnILF-IVAQlVI---NRQAIM 249 Kluyveromyces lactis
Q18386       612 TCFAHELPL-SKLVLLWDeTMMHGn--aF-PLM-IALA-ML-NRLRDKLL 654 Caenorhabditis elegans
XP_001309419 434 LAFKRSLDE-PNLERAWD-SAMcsdsphTfIIC-FCAAlII-FCY--PAF 477 Trichomonas vaginalis G3
XP_001307913 331 LLFKREFKL-ESVLRLWD-AIFshe-kpFvFIRyFCAA-ILiNSFPQLIV 376 Trichomonas vaginalis G3
XP_012814266 574 LCFKREFPD-SEALRMWEaCWAHYqt-dYfHLF-LCVA-II-VLYgddvi 618 western clawed frog
XP_002041664 190 SLFASCSSL-SVIIAMWD-LYFQNad-pFmVFF-LALI-IL-INGREQIL 233 Drosophila sechellia
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