Conserved Protein Domain Family
SRP68
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pfam16969: SRP68 (this model, PSSM-Id:293574 is obsolete and has been replaced by 465323)
RNA-binding signal recognition particle 68
SRP68 is a family that is part of the SRP or signal recognition particle complex. This complex, consisting of six proteins and a 7SL-RNA is necessary for guiding the emerging proteins designed for the membrane towards the translocation pore. SRP68 forms a stable heterodimer with SRP72, a protein with a TPR repeat. Specific RNA-binding of SRP68 is mediated by the N-terminal domain of approximately 200 residues of this family.
Links
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Statistics
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PSSM-Id: 293574
Aligned: 79 rows
Threshold Bit Score: 346.542
Created: 2-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q1ZXE8        37 LQDYKKYRQYCSKRIQRLRS--------------------QLRKQYGKK-------NYVNKIVlnggeTEKQI-NDVRYL 88  Dictyostelium d...
XP_003725432  39 HGDYQRYRSYCTRRLRRVRK--------------------SLKFSYGNRn------KFVKRQI------KEEIvKDVRFL 86  purple sea urchin
CCD82452      31 HGDYQRYHQYISRKLRRMRK--------------------SLHFQQGNRs------KVVPKKL-----TP-DIvTDPRFI 78  Schistosoma man...
GAA49270      41 HGDYQRYHQYVSRKLRRMRK--------------------SLHFQQGNRs------KVLPKKL-----TSDMV-TDPRFL 88  Clonorchis sine...
CDJ00102      35 HGDYQRYRQYVTRKIRRMRK--------------------SLRFQQGTRs------RVVPKKL-----TPE-IvTDARYL 82  Echinococcus mu...
CDS31954      46 HGDYQRYQQYVTRKLRRMRK--------------------SLRFQQGTRs------RVVPKKL-----TPEMV-TDARHI 93  Hymenolepis mic...
XP_004992655  42 HGDFQRYRKFCTRRMHRVRK--------------------NLKFTQGKR-------KFVQTRV-----GLKQVqKAVNFL 89  Salpingoeca ros...
XP_006681695  26 QQDYQRYREYCARRIRRVRK--------------------NTDMIQGKk-------RYEKKPV-----TPTSL-VDPRSL 72  Batrachochytriu...
XP_001027269  31 HSDFQRYRKYCGHKVHKLRK--------------------LMKFSHEK--------KYQKKQI-----HVERL-NDPKML 76  Tetrahymena the...
XP_002291216  42 HEDYAQYTSYCTRRLARLRHgqcvkkdllhcrmykssfgtRVEDVDGSGggsaskaRHAYRAIemiqlPAEVLgSNVNYF 121 Thalassiosira p...

Q1ZXE8        89 QISLLKTERAWSYAMDLKAQfek----------------------dndSRIGFHMNRRFGKASRNSTQLYEL-------- 138 Dictyostelium d...
XP_003725432  87 YLPLVCAERSWAYAMQLKTEgn------------------------tePRKRFHVMSRLRKAVKFAAELEAL-------- 134 purple sea urchin
CCD82452      79 ILAIFEIERSWAYAMQLKAEss------------------------teIRKRFQMCSRLRKAVARAELLCSM-------- 126 Schistosoma man...
GAA49270      89 LLKVFEIERSWAYAMQLKADsn------------------------teFRKRFQMISRLRKAVLRGNQLSEL-------- 136 Clonorchis sine...
CDJ00102      83 ILSVFEIERCWAYAMQLRAEan------------------------sePRKRFHMLSRLSKAAKCAQGLNEI-------- 130 Echinococcus mu...
CDS31954      94 ILAVFEIERCWAYAMQLRSEan------------------------seHRKKFHMMSRLRKAAKNAQNLNEI-------- 141 Hymenolepis mic...
XP_004992655  90 EIPVLSAERAWAYFREDKQLsk------------------------qeTRKLHHAGRRLRKAITWADEVVRL-------- 137 Salpingoeca ros...
XP_006681695  73 QILLFEAERSWAYAMQLKADsq------------------------yePRKKHHSIKRLCRAVSSANQLHEL-------- 120 Batrachochytriu...
XP_001027269  77 QVLLFKIENNWAYAMDLKQImqds--------------------kdgaARKQHHVNKKMAKALKWANLLNNI-------- 128 Tetrahymena the...
XP_002291216 122 YEPLYCAERCWAASMAVKAElnsggggggksssvlmgdggnvrekwssGKLRAYSVKRLRKAVKFANLVESLtmstvspp 201 Thalassiosira p...

Q1ZXE8       139 --------------C--K-LVA-DQYTIIEAHAYSSWMASSLSLTKQDFKKALEEINISKTIYEKLSE-QG-DHSQKE-L 197 Dictyostelium d...
XP_003725432 135 --------------Sq-S-DKC-DARSKLEAKAYFGYMKGMVLFEEEKWENCIETLSEAKTIYEKLAS-AL-NEEQSA-I 194 purple sea urchin
CCD82452     127 --------------EddL-SLL-DAQTKLELRAYKQWIRGILFFELQNWAVAKEHLESAQAIYDVLLQ-MV-DEDSQA-V 187 Schistosoma man...
GAA49270     137 --------------AteL-PML-DAQTKLELQAYIQWIHGVLAFELQDWMKAKEFLEATQAIYAGLMQ-TI-EEDNRG-V 197 Clonorchis sine...
CDJ00102     131 --------------It-SvPMC-GAQTKLELTAYIQWINGILHFEQQNWMKAKDLLESAQQIYTGLAS-SV-DEDLRA-V 191 Echinococcus mu...
CDS31954     142 --------------MnnV-TCC-GAQTKLELTAYINWINGLILFEQQEWAKAKELLESVEQIYTGLSS-SL-DEDLRE-T 202 Hymenolepis mic...
XP_004992655 138 --------------Vs-K-SKAfDSLTALEAQAYADWLHALTAFESKQWKDAESLFSRAKQTYTQLLKlAA-SDEEEK-I 199 Salpingoeca ros...
XP_006681695 121 --------------Cq-L-ESI-DHQTSLETQAYALRLAAYVHFERQEWQSALDVFASSRSIYDKLAH-VAvTASHAT-L 181 Batrachochytriu...
XP_001027269 129 --------------C--R-ERT-DERSYQESEAYLNFIKGIYHHERHQWEDALESYIKSRSIYLSLIS-VS-DSLQSV-F 187 Tetrahymena the...
XP_002291216 202 tlvvegeedevkeeKa-S-PPV-DEHTQMEARAYASWMRGNLALEANQWQTACTEYQTAFDLCHALAN-NT-SSENANsD 276 Thalassiosira p...

Q1ZXE8       198 YQKRIEet--------------ePIIRFCLYN----LKNEKNTSNKVSQNt----------LtIIEQ-SLEELKNQENKK 248 Dictyostelium d...
XP_003725432 195 YLQRVEei--------------sPSIRYCAYN----IGDESAINDLVKMRlk--------sGgQMST-NIDSLLAQTREK 247 purple sea urchin
CCD82452     188 YKSRIDdl--------------lPQIRYCAHS----IGDETAATDLQRMRnqa-----pdgLtLLSElQLDQLLGQARSK 244 Schistosoma man...
GAA49270     198 YSARVDdi--------------lPQIHYCAYN----IGDKSAATDLQRMRaqtt----tetGgLAEL-QLDQLLSQARAS 254 Clonorchis sine...
CDJ00102     192 YAARTGei--------------lPQIRYCAYS----VGDTSAAKELREMRag-------veGtLVEE-QLDELLKQMQTL 245 Echinococcus mu...
CDS31954     203 YISRISei--------------mPQIRYCAYN----IGDTSAASDLRDMRag-------aeGtLVEE-QLDDLLKQMQAL 256 Hymenolepis mic...
XP_004992655 200 YERKVQel--------------dASARYCLYN----LEGTGDIKSLLELRsald----tdeMdLLSD-QLDSALTAKRQE 256 Salpingoeca ros...
XP_006681695 182 CQAAMDei--------------dPNIRYCAYN----LKFKGNQTDDIESLlelrktsggpgNdLLSA-KIDLLVTERMHV 242 Batrachochytriu...
XP_001027269 188 FKEKVEfl--------------eQSIRYCHQQnngfILDTIDVIISKMGTk----------MdIEKT-PTSKVAQSEKKD 242 Tetrahymena the...
XP_002291216 277 DGNAIQqlelfdffttratnviaPLLRYCQYE----LQEKGTTPTEKMSFlqssssvsdgpNdPLQS-KLNTLKTQTLQT 351 Thalassiosira p...

Q1ZXE8       249 KSStsstttttaTTTIEWKSKSIKV-DEKLDEKLKIFNEFKKENENklpknin--asidttSNISPIFNIYDKLVYNLIN 325 Dictyostelium d...
XP_003725432 248 QAAt--------LSEVTWRGRTVPVrNEQVRAFLLTCQENEQQVSSe-------------iTDSESKVSVYESLLMQCKD 306 purple sea urchin
CCD82452     245 QASq--------VSEVDWLGISIPVkSEKAKIAILTVEESKTELEKa--------------ETLQAKLSIYESILKLCVE 302 Schistosoma man...
GAA49270     255 QAGq--------VTEVEWLGMTIPVkLEKAKMAILTVKDSDQELLGm--------------DNHNTKLSVYESVLKACVD 312 Clonorchis sine...
CDJ00102     246 QAGs--------VTEVTWLGTTIPVkLEKARLAVLALQEADEQLAKlp--------------ssYTKAAICESTLKVIVD 303 Echinococcus mu...
CDS31954     257 QAGs--------VTEVKWLGATIPVkLDKARMAVLAVQEADEQLARvps----------sfT----KSMICESVLKVLVE 314 Hymenolepis mic...
XP_004992655 257 DGNt--------IKELEWLDRTVPLkSSRLRAQITAVHAKADDIKQlp-----------sdEDEKTMMAAYDALLMAFGD 317 Salpingoeca ros...
XP_006681695 243 KARa--------IHTMEWHGYSMDIhNEDLMAMIMEMQEISAKINGevqgngivvdgrvdeSQFAGIMAEYDKLLGLGWD 314 Batrachochytriu...
XP_001027269 243 Q-----------LIEVDYLGSKYPIkNQKAIYSYRQVEDCQKRIHElq-----------rkTSKTNTQEEQDSILAIYNE 300 Tetrahymena the...
XP_002291216 352 QATsg-----ssMSQIVFRENNIVVeTKELRMALLKVQNLKMEWEEeks----------ggGGGGSNDAKFMALLNGYDD 416 Thalassiosira p...

Q1ZXE8       326 CETIVKNDLStlvr---------------vnlK----------------NKSVK---------------SEIEE------ 353 Dictyostelium d...
XP_003725432 307 SLQIIREELKadp-----------------naK----------------AKGQR---------------QDGPV------ 332 purple sea urchin
CCD82452     303 AITSVRDELRtaiasepsvtgdkntaavvassK----------------FGQTL---------------GSEKV------ 345 Schistosoma man...
GAA49270     313 AIGAVRDEIRaa------------------lsT----------------EGAVAa-------------gADKKMaaavaa 345 Clonorchis sine...
CDJ00102     304 ALVAIREEMRwl-------------------sNs---------------EGVASagllpvqtsqkanatGIEKL------ 343 Echinococcus mu...
CDS31954     315 ALMAIREEMRli-------------------sNadavaaagllttqsaeKAHST---------------GIEKL------ 354 Hymenolepis mic...
XP_004992655 318 ALATTDDLADee------------------lkA----------------AGGLT---------------SDAIK------ 342 Salpingoeca ros...
XP_006681695 315 AAKLSERDIKedlv---------------avmK----------------VKSSK---------------SDMHS------ 342 Batrachochytriu...
XP_001027269 301 AFNNFDECIKvi-------------------qK----------------EKSDE---------------KNSEA------ 324 Tetrahymena the...
XP_002291216 417 TISLTNQELKqla-----------------plK----------------SGPAV---------------NAKKF------ 442 Thalassiosira p...

Q1ZXE8       354 -------QST---RILLAYIMYHKMKYLYERNSILITMMQRVLDGEKVDESAI---Kk---KVKKVTWNDLVRLSTHQVK 417 Dictyostelium d...
XP_003725432 333 -------STT---QYLHTYLTYIRLTRTIERNILLAETLKANLQTREDGGEQE---Sa---NQKRTKPQDLIRLCDIILQ 396 purple sea urchin
CCD82452     346 -------SRL---QLLYTYLQYLKLSKTIDRTLLHIETTISSLAEGSH----K---RnqlaTSAYPKPQELSRLYDTLVQ 408 Schistosoma man...
GAA49270     346 ssstdkvSRL---QVLYAYLQYLKISKTIERTLLHIKGALSADGLEAAGHVKD---GlgtsS--FPKPQELSRLYDTLVQ 417 Clonorchis sine...
CDJ00102     344 -------PRL---QRLNIYMQYSKLSKTIWRTLYQLETLMSNVAPEHHHASWN---Lit---sgYQKPHEFARLYDSVVQ 407 Echinococcus mu...
CDS31954     355 -------PRL---QRLNTYIQYLKLNKTIWRTLYQLDSLITKVAPEHQHPSWN---Lvt---sgYHKPHEFARLYDTVLQ 418 Hymenolepis mic...
XP_004992655 343 -------ENLaqlQFVRAYLEFHRLQHTLDRNLAMISRCMRAYTGEDDG----------------SRPEDIVRLFDLAAQ 399 Salpingoeca ros...
XP_006681695 343 -------AML---KLIKEYVTYTRLEHTFDRDILLEQATSMRLKNLVHSSGSV---Ek----RPSQRREELIQLDITMLQ 405 Batrachochytriu...
XP_001027269 325 -------ENLi-yTNILSFLNLNKQKFILDRNIILIKNAVQQFDKEDGVNNLEaltTkkafKLKLIRPTEIIKLCDNLLQ 396 Tetrahymena the...
XP_002291216 443 -------QLV---NIL-GYAKHQKLKLVMERNEDMANGILKKQSGRSTGKNNK---Kke---mtLKHLEELAHLYDALLQ 505 Thalassiosira p...

Q1ZXE8       418 VYTIMSESR-D-TDS-------------NKEIARDQDAQLILLKSIRLYYIAVCLA--KSLKFSETMAVLDRVLTNIQNV 480 Dictyostelium d...
XP_003725432 397 NLSEIPQLP-G-LEG-------------DVELQQEVEAKTLKFKAYRCFYLAQSYS--QAKKWTEAAALFERAMSRAESS 459 purple sea urchin
CCD82452     409 NFQEIISLP-ClVQD-------------HIGLKDLLYAKMLSYRSYRCYYLALAYN--CSKKYTECSALLTRAIQHAEKA 472 Schistosoma man...
GAA49270     418 NLQELIGLP-GaVQE-------------HMGLKALLQAKIVAYRSYRCYYLAFTYI--HGKRFAECSALLQRSRRHAEEA 481 Clonorchis sine...
CDJ00102     408 NLQEVLTLPgG-IQD-------------NAEIRALIKAKIAAYKALRCYYLALAYL--RNNRFLESSSLLQRCQKEVKEA 471 Echinococcus mu...
CDS31954     419 NLQEVLTLP-GeIEE-------------NVDIRTLIKAKILAYKAMKCYYLALAYL--RSNRYLECSSLLQRCRLETKEA 482 Hymenolepis mic...
XP_004992655 400 SLDEMLEVE-F-AEE-------------DDAFVARADAYKPYFRAMRCFYIAESFR--LLGKLREALAMFDRASEVAAVA 462 Salpingoeca ros...
XP_006681695 406 VVNEMKELD-I-IET-------------DLALGHLVSSKGFFVVAQRLAHTADIYT--ADQKYAEALVLLNKAMEQVHLS 468 Batrachochytriu...
XP_001027269 397 VFKQIIEVE-R-QNT-------------NLENYRKLDVLEFHFKAIRCYYVSCVYL--ANSKYIETLSLLKVAENIVTNS 459 Tetrahymena the...
XP_002291216 506 DARAVAALP-G-GGSvddfdgnatlstvEDEFLLEANANILRLRSLRCYYLAKMHAspLVSKYSQAVALLNQAESLAHEA 583 Thalassiosira p...

Q1ZXE8       481 RKTNTKNQQ-----------------ILNDTNELESNIKKQRSQIHANSF-------------IQqL----S-ENqdlkn 525 Dictyostelium d...
XP_003725432 460 RKEWKAIKSisvk------------aelTELDELIQQINGVKYSAHAASI-------------LD-Ss---E-VNesmak 509 purple sea urchin
CCD82452     473 VTSLEHSIStwtkaeeciapgpspdaLSKSLQSLILQAESEDFTCKAASM-------------LD-Kv--eE-NEpvstt 535 Schistosoma man...
GAA49270     482 LQALSPTTAswtdtesaaspgpscdqLITELTSLITQTEAEDLTCRAVYM-------------LD-Ls--dS-GDrpfdt 544 Clonorchis sine...
CDJ00102     472 EASLSKANLpecteaea-vpghsrpfLLQLLRDLQDQMDAEMLACKAGYM-------------LE-LsaggT-SNefvdd 535 Echinococcus mu...
CDS31954     483 TISLEKSTLsesvesea-vpghtkafLLDLLKDLEGQIDSEMLACKAGYM-------------LE-La--aG-GNdtasi 544 Hymenolepis mic...
XP_004992655 463 RTKLQAQPAefa------------epLLAALDSVQVRMRAVRVGMQAGAF-------------LQaSr--rQ-EDesaar 514 Salpingoeca ros...
XP_006681695 469 RTSVVEFKRkiikhd-----qqmavnMTKLLDVLSQSICNRSLITKAKVY-------------FE-Nd--dKvPYvslsk 527 Batrachochytriu...
XP_001027269 460 SKKFVDMRDnfv------------edYVEESDILMKKIKYLEIKAKLGLVentteeetvitekLA-Ds--nL-DGkvtnk 523 Tetrahymena the...
XP_002291216 584 LEEIGACDQmer-----------geeILGSLQSVADEMKGEKCRVLAIAY-------------LA-Kt--sS-MKss--- 632 Thalassiosira p...

Q1ZXE8       526 qmsslsiggittasgksndL----ISGLDSF--DTSFLteKK-------LVQ-LPPQLQPVQAKPIFFDLAFNS 585 Dictyostelium discoideum
XP_003725432 510 lnita-----ssssdtsrpV----SERLGDYr-PASEVdpTKp-----nLVA-FPPAFKPVPCKPLFFDIALNH 567 purple sea urchin
CCD82452     536 plagt-----tgvdasrkvL----IDRLDIY--ADEKSveKSfnnfvypFVH-LPPKFHPVPVKPIFFDLALNH 597 Schistosoma mansoni
GAA49270     545 ses--------enklsqkvL----LDRLDHY--VECNAveKSfttqpypFVQ-LPPHFEPVPVKPIFFDLALNH 603 Clonorchis sinensis
CDJ00102     536 atasa----svprsvlkepL----IRSLGEF--VPEKVilRKlttqpapLVP-FPPEFEAIPVKPTFFDLALNH 598 Echinococcus multiloc...
CDS31954     545 eevnis--aalprivlkepL----IKSPGEF--VPEKVimRKlttqpapLVP-FPPEYEAVPVKPAFFDLALNH 609 Hymenolepis microstoma
XP_004992655 515 tdeegavpdddadrladvpL----SETINTL--DTSAAvlKRp------LLQ-FPPEFQAMSCKPLFFDMGSSH 575 Salpingoeca rosetta
XP_006681695 528 tvqdm-----sigthkinqMgvgrAEHMKVFfqPSEGVi---------pVVQsIPPAFEPVSFKPMFYDLAYlg 587 Batrachochytrium dend...
XP_001027269 524 tiqsl-----mkeqeqgnkLnv-gINRLNSI--P---------------IFA-LPPKPLLAGCKPIQFDLvdey 573 Tetrahymena thermophi...
XP_002291216 633 -----------------lpL----LQRLHDY--DIPSSptSA-------VSC-VPPKLEPMACKPIFFDVALNY 675 Thalassiosira pseudon...
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