Conserved Protein Domain Family
HIP1_clath_bdg
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pfam16515: HIP1_clath_bdg (this model, PSSM-Id:293123 is obsolete and has been replaced by 465154)
Clathrin-binding domain of Huntingtin-interacting protein 1
HIP1_clath_bdg is the coiled-coil region of Huntington-interacting proteins 1. It carries a highly conserved HADLLRKN sequence motif at its N-terminus which effects the binding of HIP1R to clathrin light-chain EED regulatory site. this binding then stimulates clathrin lattice assembly. Huntingtin-interacting protein 1 (HIP1) is an obligate binding partner for Huntungtin, and loss of this interaction triggers the cascade of events that results in the apoptosis of neuronal cells and the onset of Hungtinton's disease. Clathrin light-chain binds to a flexible coiled-coil domain in HIP1 and induces a compact state that is refractory to actin binding.
Links
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Statistics
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PSSM-Id: 293123
Aligned: 31 rows
Threshold Bit Score: 102.713
Created: 16-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_003451671  468 HAELLR----KSADTVKMLSVTQQTQEEVERTKQQLTFEMDRVKQEADMKME---EQRFEVERVKRELEEKMAEVTRIKA 540  Nile tilapia
XP_005016388  580 HAELLR----KNADTAKQLTVTQQSQEEVARVKEQLEFQVEQVKREAEMKLE---DQSVQMEQLRRELDARRDELDQAQS 652  mallard
XP_008767489  461 HAELLR----KNADTAKQLTVTQQSQEEVARVKEQLAFQMEQVKRESEMKME---EQSDQLEKLKRELVAKAGELAHAQE 533  Norway rat
XP_003222791  459 HAELLR----KNADTAKQLTVTQQSQEQVARVKEQLAFQMEQAKRESEMKLE---DQILQMEQLKREMESKKDELAQLQE 531  green anole
NP_001116907  462 HAGLLR----KNADTAKQLTVSQQNQEEVARIKEELEFQMDQVKRESDLKLE---DQSFQTEQLKSEIEAKKKELLLIQQ 534  western clawe...
XP_005989022  473 HAELLR----KNADTAKQLTATQQVQEDVARTIETLQFEVDQGKRESEMKLE---EQTFLTEQLKQELEARKEELANVQL 545  coelacanth
XP_005459699  453 HADLMK----KNTETVKILSSTKQEHDDLQRAKYQLETELESLRREKTNVMN---QQQMEVDRLNQELLEQRAELATLRS 525  Nile tilapia
XP_005459699  548 revLLRsareKDAELTTLRQQAQLQQSSLDLERDRTNRELEDLRAQLQRQLAinaEQKLEIDRLKRDLESTRAELAKANN 627  Nile tilapia
XP_011479732  453 HADLMK----KNAEAVRMLSSSKQEQDDLLRTKMNLEKELENLRWDRQNKVQ---QQQQEVERLSKELQDQRAEVALLRS 525  Japanese medaka
XP_011603054  451 HADLMK----KNADTARLLSATKQEQDDLLRAKRQVENELENLRQEKRNMVN---QQQQEAQQLNQDLLQQKAEVTALRS 523  torafugu

XP_003451671  541 TLQSSEKTSEHMNSSMTALQAEKERL 566  Nile tilapia
XP_005016388  653 SLSHAKQAGSELSAQLETLQAEKEQL 678  mallard
XP_008767489  534 ALSRTEQSGSELSSRLDTLNAEKEAL 559  Norway rat
XP_003222791  532 SLGRSKQLGSDLNSQLDALQSEKDTL 557  green anole
NP_001116907  535 SLSSTEESKSQLNSTLMSLEVEKDTL 560  western clawed frog
XP_005989022  546 SLNSSEQAGSQLKSRLQELQDENSTf 571  coelacanth
XP_005459699  526 TLESKEKEGSQVSSSLTALQAEREVL 551  Nile tilapia
XP_005459699  628 ILQNKEMSGTQLNNTLAGLQVEKEGL 653  Nile tilapia
XP_011479732  526 SLESKETEGSRVSGTLAALQAERDTL 551  Japanese medaka
XP_011603054  524 SLENKEKEGSQVSSSLAALQAEREVL 549  torafugu
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