Conserved Protein Domain Family
LYRIC
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pfam15686: LYRIC (this model, PSSM-Id:292314 is obsolete and has been replaced by 434858)
Lysine-rich CEACAM1 co-isolated protein family
LYRIC is a family of proteins found in eukaryotes. It is a type-1b membrane protein with a single transmembrane domain and localizes to the endoplasmic reticulum and the nuclear envelope. It is also found in the nucleolus, suggesting functional relationships between these two cellular compartments. It is found to be colocalized with tight junction proteins ZO-1 and occludin in polarized epithelial cells, suggesting that LYRIC is part of the tight junction complex. LYRIC has been shown to promote tumour cell migration and invasion by activating the transcription factor NF-kappaB.
Links
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Statistics
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PSSM-Id: 292314
Aligned: 14 rows
Threshold Bit Score: 341.407
Created: 16-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9Z1W6         7 QDELAQQAEEGSARLRELLSVGLGFLRTELGLDL--GLEPKRYPSWVIL-VgTGALGLLLLFLLgy-gWAAAC--AGAR- 79  Norway rat
XP_003444226   6 RGLALEKAELLSSHLKELLSSGQGYVRARFGVDL--GLKPELYPTWVIL-S-TVAAGLLLLLSLs---WAAVC--GGLL- 75  Nile tilapia
XP_011607236   7 HGFTLEKAEQLSGRLREVLSSGQAYMLTRFGVDL--GLDPDLYPTWIVL-S-ATAVVLLLLLAL----SWAAV--RGAP- 75  torafugu
XP_007488206  10 QDVLAQQAEEGSAPLRELLSAGLYLLRTELGLDL--GLEPHSYPAWVIL-L-GTAAVGLLLLLLlglgWAAAC--AGAR- 82  gray short-tail...
XP_012427396   7 QEAAARWAEEAAARVRDALSGGLGLLRAELGLEL--GLDPQALPAWLALaV-PAALGFVLLGLL----LAAAC--GGGL- 76  zebra finch
XP_006001076   6 QDAAAQQAEVVSARLRELMSSGLGLLRTELGLDL--GLDPERYPSWAIL-L-VAVLGLLVVGLV----WAATC--AGRKg 75  coelacanth
XP_011483200   5 KDAASQQVKLLARRLNEELSKGLGWLRSELGVDL--GLKPELIPPWAIV-L-AACAGLLLMVAL----WASVC--RAVF- 73  Japanese medaka
XP_005816607   5 QDAASQQLRLLTSRLNELLTKGLEWLRSEFGVDV--GLKPELIPPWIIL-L-AACSGLLLMVAL----WASVC--RTIF- 73  southern platyfish
NP_001007136   6 QALATQRAEYVSDRIRGLLSSGLDFLRAELGVDL--GIKPEKCPSWLIL-S-AALIGLLLLVVL------AAC--GRRK- 72  zebrafish
XP_008106595   8 PESVARQAEEVSARLREVLSAGAGLLRTELGLELppALEPQRLPGWLLL-LaTSLLPLLLLLVLl---WGLRCgrGGSA- 82  green anole

Q9Z1W6        80 KKR---RSPPRKRE-----EV--------------TPptp--apeD-----------------------------PAQLK 106 Norway rat
XP_003444226  76 AGKkrgSPVTHGSS-----RS--------------SSsggggeplK-----------------------------AGFAK 107 Nile tilapia
XP_011607236  76 LLRk--TPASRADL-----RS--------------CEp------dK-----------------------------AGLAK 99  torafugu
XP_007488206  83 QRRrspPRRREEAStpvpvPA--------------PE--------D-----------------------------GALLK 111 gray short-tail...
XP_012427396  77 RKKparSAAVRKGD-----EAvgagltagggpgkaAG--------P-----------------------------GPGQL 114 zebra finch
XP_006001076  76 AGRekePLSSSVAA-----VS--------------SS--------R-----------------------------APAGK 99  coelacanth
XP_011483200  74 KKRpavRPADDGAG-----IK------------------------------------------------------QSVSK 94  Japanese medaka
XP_005816607  74 RKRpavSPVDDGVE-----GK------------------------------------------------------RGASK 94  southern platyfish
NP_001007136  73 RRaapvTASPRSIA-----AA--------------Apv-----------------------------------ktSAPPK 98  zebrafish
XP_008106595  83 RPrrlrRTTAEEEE-----ED--------------Ede-----eeDddeeeeaaatpkaglarggggphkgppltGPAGL 138 green anole

Q9Z1W6       107 NLRSE--EQKKKNRKKLPEK-PKPNG-RT-VE-IPeD-EVVRTP-RSITAKQP--------------------------- 151 Norway rat
XP_003444226 108 TAKPE--EQKKKNKKKTVEKkSQSNGqPV-TV-AQ-E-EVKVAE-AVSKLPAQ--------------------------- 153 Nile tilapia
XP_011607236 100 PVRAE--EQRKRNKKKPPEKtHQSNGqPGnVA-PQ-R-ENPPGT-VLKPKEDK--------------------------- 146 torafugu
XP_007488206 112 NLKSE--DSRKKNRKRLTEK-PKPNGrTV-LE-VP-E-EEVVTTpRREAQQQQ--------------------------- 157 gray short-tail...
XP_012427396 115 NLKGD--EQKKRNRKKLPERaARPNGrSF-ID-VS-EdEVIQTV-RKDNIKQP--------------------------- 161 zebra finch
XP_006001076 100 NQKID--DQKK-KAKKKSAEkGKPNGrTA-VElPE-E-EAVPVL-LKETLKQP--------------------------- 145 coelacanth
XP_011483200  95 PVKSD--EPK--KKKKKAEKkAQPNGrAV-PE-PQ-E-EEAIAS-EEIVPHHH--------------------------- 138 Japanese medaka
XP_005816607  95 PVKAE--EPK--KKKKKAEKkAQPNGrAV-AE-AQ-E-GATACE-ERVPHHQP--------------------------- 138 southern platyfish
NP_001007136  99 TVKTEpsEPKKKNKKKAADKkAqangq--tvaePQ-E-EIKVTG-EKKKAPAPtptrapapaptrapapaptpasapapv 173 zebrafish
XP_008106595 139 LLKAD--EQKKRNKKKAPEK-Agrlng-qpaheISeE-EITPTV-RRENLKQP--------------------------- 185 green anole

Q9Z1W6       152 -----------------PETDK-----KNE-----KSKKN---KKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKR 201 Norway rat
XP_003444226 154 -----------------IKTEK-----KQEvqapvQVKKN---KKKNKTDVKPVQLLSSNDGKEPDDGVWETKVSNREKR 208 Nile tilapia
XP_011607236 147 -----------------TLVQIv---qNPV-----QVKKN---KKKARTDVKPVQHVSTNDLKEPDEGAWETKVSHREKK 198 torafugu
XP_007488206 158 -----------------LDAEK-----KNE-----KLKKN---KKKSKSEVKAVQNSTRHDRKEVDEGAWETKVSNREKR 207 gray short-tail...
XP_012427396 162 -----------------VDTEK-----KNE-----KSKKK---KKSKGDSK-TVQDSSRLDGKEVDEGAWETKISNREKR 210 zebra finch
XP_006001076 146 -----------------LETEK-----KTE-----KSKGK---KKKPKAEAKQVHDVSALEGKEFEEGAWETKVSNREKR 195 coelacanth
XP_011483200 139 -----------------QPPPPqgkseKTA-----EGKKS---KKKPKQAAKETKIVTA-DGKEPEEGTWETKVSNKEKR 192 Japanese medaka
XP_005816607 139 -----------------PPPQV-----KTD-----KVAETkksKKKAKPAVKETKAATG-DGKEPEEGTWETKVSNKEKR 190 southern platyfish
NP_001007136 174 pvpapkpkqkpaptpaqPPADT-----KT--------KKN---KKKAKPELKTAQDVSSTDGKEPDEGAWETKVSNREKR 237 zebrafish
XP_008106595 186 -----------------SDVEK-----KTE-----KSKKN---KKKQRGDAKTVQDQSRADGKEADEGAWETKISNREKR 235 green anole

Q9Z1W6       202 QQRKRDKVLTD----SGSldst-ipgiENTITVTTEQLT-TAsfpvGSKKNKGD-------S---HlnvqvsnFKSGKGD 265 Norway rat
XP_003444226 209 QQRRKEKGPEDsg-gPGS---------VEASKTHVEATVpAA----VNKRNRGN-------HesfH-------SRTTGKG 260 Nile tilapia
XP_011607236 199 QQRRKDKGPEDsg-sPGG---------TAAPKPHVVTAL--------TKKNRGN-------S---D-------SRGAG-- 241 torafugu
XP_007488206 208 QQRKRDKVQPD----TGPldpa-vsgiESGYTVTTEQLI-TAsfpvGSRKNKGDsllnvqgS---N-------FKSGKGD 271 gray short-tail...
XP_012427396 211 QQRKRDKVLNDgg---sGesnl--qgiENTVTVPIEQLMpTPslpvGLRKNKGD-------Al-lN-------AQINSSK 270 zebra finch
XP_006001076 196 -QRKRDKVLNDvg---sGdanl--hgtDATTVASAEQPTaMAtvsiVPRKTKGEpvhtnqlT---G-------VKSGTGD 259 coelacanth
XP_011483200 193 EQRKKDKSSSDgs-sSPGggntpvsvpPEQPKTTSAGIPaPTn----QKKKQE----------------------SARVK 245 Japanese medaka
XP_005816607 191 EQRKKDKNSSDgsasPGGgd-----tpVNAPPEQPRASAaPPappaSQKKKKGE-------S---A-------------- 241 southern platyfish
NP_001007136 238 qQRKKEKGPGEssgsPESg-----------dRASMKVEQpVVtatagNKKNKe----------------------SSRVK 284 zebrafish
XP_008106595 236 qQRKRDKVLTD----TGPesni--samENSVSLSTEPLTsSAsfsvgPRKNKGDtvlnvq----------vnnskSGKGD 299 green anole

Q9Z1W6       266 STL-Q------VSSGLNENITVNGGGWSEKSVKLSSQLSAGEE-KWN-S-VPPaSAGKRKTEQSAWTQDPGDtna----- 330 Norway rat
XP_003444226 261 DAA-SeavkdkVSSSWRKEPSVNGGGWNDMSLKIPGQMSTMEGnKWS-AiSAA-THYRAPPEPQPWAQESQA-------- 329 Nile tilapia
XP_011607236 242 --K-GstatraAPPGRKEQPSVNSGGRTDASVKTAEQMGAARSsVHT-A-AQF-SVSQKHQ--------TQA-------- 299 torafugu
XP_007488206 272 LTL-Q---------GLNENPTVNGGGWNEKSIKIPSQISAGEEkWTS-V-SSA-SAGKRKIEPSIWGQDTGDtsa----- 333 gray short-tail...
XP_012427396 271 PAK-GessipqVSPGLSESHTVNGGSWNEKSVKISSQIGVGEEkWTS-V-PST-AAGKRKTETLAWGQDTGDang----- 341 zebra finch
XP_006001076 260 S----------VSQGWIEAPDVNGGAWTDVPMKIPSQISGGEEkKWTpM-QAT-SAANRNQETTTWRPDTGDtngpakdw 327 coelacanth
XP_011483200 246 PEK-VeaavtpA--NSSEVVDA-AAAKGTLKVRGPSHNVPSKQaSWT-A-S--------IQPAPLWRSGIDD-------- 303 Japanese medaka
XP_005816607 242 EAK-AekaeaaVSQANSSVVPEAAAAAADMAVKVAPHSAALKTsSWT----------TQRQTASLWRAGSDE-------- 302 southern platyfish
NP_001007136 285 ASK-GdaiiapVTSAWNDVNSVNGGGLTEVPVKQAIQSNALNNdKWS---AGKkTSGHKNREnstWKQESEG-------- 352 zebrafish
XP_008106595 300 TTLqQ------VPSGLNEGPTVNGGNWNEKPVKISPQINTSEE-KWTp--V-SsAGGKRKNEtsaWGKDTGDngn----- 364 green anole

Q9Z1W6       331 ----------------ngkD-W-----GRNW-SDRSI----------------------FSGI----------------- 348 Norway rat
XP_003444226 330 -------------------TaWsg-idGRIK-ADLSPv--------------------sFSML----------------- 351 Nile tilapia
XP_011607236 300 -------------------A-Wss-seGQMK-SGTSPa--------------------tFSAL----------------- 320 torafugu
XP_007488206 334 ----------------ngkD-WgvslvGRTW-GERSL----------------------FPGIaswsgnvdrrvnnsteq 373 gray short-tail...
XP_012427396 342 ----------------ngkD-WgvslvGRPW-KERSLftpiaawnvdarintseqnsasFSSF----------------- 386 zebra finch
XP_006001076 328 saplvrktwgehtlfpsigT-Wpg-vdGRVKtTGQNTa--------------------sFSTL----------------- 368 coelacanth
XP_011483200 304 -------------------S-WtvidrPIQS-AELNLv--------------------sLARL----------------- 325 Japanese medaka
XP_005816607 303 -------------------S-Wa---vPVPS-AELNLv--------------------sLTGL----------------- 321 southern platyfish
NP_001007136 353 -------------------P-Ltg-ldGRIK-AEPNQv--------------------nLTML----------------- 373 zebrafish
XP_008106595 365 -----------------gkD-WgvslvGRTW-GERTL----------------------FPGI----------------- 386 green anole

Q9Z1W6       349 ---------------GST-----------AEP--------VSQs--------------------T--------TSDYQWD 366 Norway rat
XP_003444226 352 ---------------GLN-----------TTD--------PIS---------------------N--------SVDLQWA 368 Nile tilapia
XP_011607236 321 ---------------GCD-----------ATE--------PPS---------------------N--------PAERRGS 337 torafugu
XP_007488206 374 nsapfsslalnttvsGST-----------TEV--------SQS---------------------T--------ASDFQWD 405 gray short-tail...
XP_012427396 387 ---------------GLT-----------PGV--------SGS---------------------NsesvsqagTSDFQWD 411 zebra finch
XP_006001076 369 ---------------GLN-----------SSVsgsssepvPQS---------------------S--------TTDLQWD 393 coelacanth
XP_011483200 326 ---------------GVG-----------PAQ--------PQS------------------------------VSSLSWV 341 Japanese medaka
XP_005816607 322 ---------------GA--------------P--------QAQ---------------------P--------VSDLTWL 335 southern platyfish
NP_001007136 374 ---------------GLN-----------PSS--------GEtgs-----------------ksS--------IEIGKWD 394 zebrafish
XP_008106595 387 ---------------AWSgvdgrintpeqSSP--------SFsslglnpkvsgsssepvsqpgtT--------DFQWDLN 435 green anole

Q9Z1W6       367 GS-RN---QphiDDEWSGLNGLSSADPSSDWNAPAEEWGNWVdEDR----ASLLKSQEPISND 421 Norway rat
XP_003444226 369 SR-PK---V---DDEWSGFNGMAAADPSSDWNAPVEHWGNYE-EPPvlvtPAPVQKEQPVPNK 423 Nile tilapia
XP_011607236 338 --------Q---YDEWSGFNRTSPADPSSDWYAPVEHWGNYE-GVSv--mAAPPVKQEPAPHV 386 torafugu
XP_007488206 406 VS-RN---QphiDDEWSGLNGLSSTDPSSDWNAPAEEWGNWV-DEEk---ASFLKSQELAhde 460 gray short-tailed opossum
XP_012427396 412 LS-HAqtpV---DDEWSGLNGLSSADPSSDWNAPAEEWGNWVdEEKv---ASVPQREErsdtq 467 zebra finch
XP_006001076 394 SVlTP---I---DDEWSGANGLPPADPSSDWNAPAEEWGNWV-EEEa---AQPPQPEEPVSEV 446 coelacanth
XP_011483200 342 SQ-PR---V---EDEWSGING-ASSDPSSDWNAPSEAWGNYE-EPTt---ETPLAQEKPLPEs 392 Japanese medaka
XP_005816607 336 SQ-RR---V---DDEWSGLNG-GSADPSSDWNAPSEAWGNYE-EPTa---EPAGPQEPPLPEa 386 southern platyfish
NP_001007136 395 KT-PV---V---DSEWSSFNGLGSVDPSSDWNAPSELWDNFe--AKv---DASALKEIPVSKP 445 zebrafish
XP_008106595 436 RN-QA---Hvd--dEWSGLNGLSSADPTSDWNAPAEEWGNWveeEKs---PSIPQLEEGLSEA 489 green anole
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