Conserved Protein Domain Family
Ripply
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pfam14998: Ripply (this model, PSSM-Id:291659 is obsolete and has been replaced by 464433)
Transcription Regulator
The precise function of this family is not clear, but it is thought to play a role in somitogenesis, development and transcriptional repression. Ripply is also known by an alternative name, Bowline. Bowline, is an associate protein of the transcriptional co-repressor XGrg-4. This family contains two conserved sequence motifs: WRPW and FPVQATI. The WRPW motif is thought to be required for binding to tle/groucho proteins. Ripply3 is also known as Down Syndrome Critical Region Protein 6 homolog. This family of proteins is found in eukaryotes. Proteins in this family are typically between 109 and 154 amino acids in length.
Links
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Statistics
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PSSM-Id: 291659
Aligned: 29 rows
Threshold Bit Score: 102.354
Created: 30-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q2WG77        59 LWRPWL-SSINDQPRQARSLVdwadnrataaeaA----KTDSDFHHPVRLYWPKSHSFDYLYSAGEILLNNFPVQATINL 133 house mouse
Q2WG78        17 LWRPWS-LSPTEARGHKTLAGgvr-------saR----PSGGVFHHPVRLFLPRSRMQEYLSRLGSSVLASFPVQATLHF 84  zebrafish
Q924S9        39 PWRPWMsPPPGDAELTRTERPceswgd-qhtsgS----KGAFGFQHPVRLYLPVSKRQEYLQSSGEKVLASFPVQATIHF 113 house mouse
XP_002830717  38 PWRPWI-QTPGDAELTRTGRPleprad-qhafgS----KGAFGFQHPVRVYLPMSKRQEYLQSSGEQVLASFPVQATIDF 111 Sumatran orangutan
NP_001120477  39 LWRPWL-LRAGDRELDGQQRRlgeadgdhrntgP----KGALGFQHPVRLYMPKSKTSEYLQHMGKKVLANFPVQATIHF 113 western clawed ...
XP_004762204  38 PWRPWI-LTSREAELTRTGSRlepggd-pqtpgS----KGAFGFQHPVRLYLPISKRQEYLQSSGEKVLASFPVQATIHF 111 domestic ferret
XP_003364231  38 PWRPWI-RSPQDAEPAGTGNPpesggd-qqtsgS----KGAFGFQHPVRLYLPISKSQEYLQSSGEKVLASFPVQATIHF 111 horse
XP_007665362  16 LWRPWI-LTARDTELTRNQRLpdsdgd-pscfgS----KGALGFQHPVRLYLPRSKRHEYLHSSGEKVLASFPVQATIHF 89  platypus
XP_010713587  35 LWRPWL---PQEEYTTRRQREqmdtaqpldasgDhssdKALALFRHPVRLLWPKSRCFDYLYSVGEKLLENFPVQATLCL 111 turkey
XP_852844     55 LWRPWL-SSARDLPQWWGKKGieaatggatgakVi---KAASEFHHPVRLFWPKSRSFDYLYSDGEILLQNFPIQATINL 130 dog

Q2WG77       134 YED-SDS 139 house mouse
Q2WG78        85 YND-EDS 90  zebrafish
Q924S9       114 YNDdSES 120 house mouse
XP_002830717 112 YDD-EST 117 Sumatran orangutan
NP_001120477 114 YNddsds 120 western clawed frog
XP_004762204 112 YNdesds 118 domestic ferret
XP_003364231 112 YNDasds 118 horse
XP_007665362  90 YNddsdt 96  platypus
XP_010713587 112 YDD-Sds 117 turkey
XP_852844    131 Yedsdde 137 dog
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