pfam14835: zf-RING_6 (this model, PSSM-Id:291501 is obsolete and has been replaced by 434253)
zf-RING of BARD1-type protein
The RING domain of the breast and ovarian cancer tumor-suppressor BRCA1 interacts with multiple cognate proteins, including the RING protein BARD1. Proper function of the BRCA1 RING domain is critical, as evidenced by the many cancer-predisposing mutations found within this domain. A dimer is formed between the RING domains of BRCA1 and BARD1. The BRCA1-BARD1 structure provides a model for its ubiquitin ligase activity, illustrates how the BRCA1 RING domain can be involved in associations with multiple protein partners and provides a framework for understanding cancer-causing mutations at the molecular level. The corresponding BRCA1-RING domain is on family zf-C3HC4_2, pfam13923.
Jiyao W et al.(2023). "The conserved domain database in 2023.",