Q7SEI5 452 ERRS-TVSI---YILCRVLLEVFTQST-LAS-ITPEMEDKLEKIIFQQLKS--T--EPDSL---LIS-P-LKLA--NWNL 514 Neurospora cr... Q553W1 168 ERYK-LIVD---YIFCTTISSILNSLT-KEN-LTDAMGIQIESMCFESFKL--E--KRLST---NSS-P-MIIP----DL 228 Dictyostelium... XP_002112298 110 ERRD-LAVD---FLFCLVLIEIIKKLP-DCP-VPDHLLQLIEDLAFKHFKE--R--KSYNS---SESqH-NGQL--IADL 173 Trichoplax ad... CDJ01184 193 ERRD-LCID---ILYCQALTSVLKQLPyHPG-H-DEIINKILDRAFKHFEY--K--ENLQT---KPN-A-ENINt-VADM 256 Echinococcus ... CCD81486 156 pelS-LAID---IIFCHVMLAVLKQLPfHPG-HN-DVIESILEQCFGRFNY--R--EDLQP---KNS-E-NINL--VADL 218 Schistosoma m... XP_004346655 411 ERAT-LISE---LIFCRIVSALLH-TV-KVN-IPQQIVTDVENASLLHFKS--V--EQLYPq--APE-R-NREE--LVEF 473 Capsaspora ow... CBY19391 92 ERRTrQGVE---FIFCHLLIETLKQLN-VHP-IPERDINTILNLAFEQFESeqA--DPKIC-----------------EL 147 Oikopleura di... XP_001771126 84 fQRK-LAVE---CIFCSACIRIVECCR-AEG-LTETLWAGLEKFAFDWLLN--A--DRVVSpaeYPS-L-VDLR--GLLL 149 Physcomitrell... XP_001743412 168 dgkteLVAIgknVLALHALRRILRSSG-NETrLTSHVMERILTAAIARFDR--Q--EQIYG---GEH-TgLDGT--VADL 236 Monosiga brev... XP_002679110 168 ERKE-LAAD---YILSLTVLLTLGSYR-QPE-LSIKNCEQVEFLCMDRFKK--AhvNITTG---LES-L-QESKkkVLDL 234 Naegleria gru...
Q7SEI5 515 FAQLL--GAMSAISFTSVADR---FINDLERSMQDlntkistgGRDV-ESRIE--LVLIGMKHLRIRLSPPDAWERSCNF 586 Neurospora cr... Q553W1 229 CASIL--GQLSKYRLRSVSSR---FFKEFQSCLSs----------nTlKNKTF--SILQGIRFLKVKISSESKLKQSLEF 291 Dictyostelium... XP_002112298 174 YAEVL--GVLSHGRAQGVRKR---FLKELKGDQPY--------DV------TV--SVVMGMRFCSLKMFPVEELEASFHF 232 Trichoplax ad... CDJ01184 257 YAKVV--GELSQTRFNLVRQH---FSTRLEHLRAKe------sSSHT-MHSII--SLLMGMKFFRVKMHPIEEFVSYFAF 322 Echinococcus ... CCD81486 219 YAEIV--GLLFQSRFALVRHK---FMSCLNDLRSKe------nSQNN-RASIV--SLIMGMKFFRVKMHPIEDFVKCFTF 284 Schistosoma m... XP_004346655 474 YAEVL--GALSLSRFDCIRRR---FLVELH--QNH--------PPHI----LI--NITRGMRFVRLPIYPIDALEESFTF 532 Capsaspora ow... CBY19391 148 YAEAL--GVVSEHRHPQVRQR---FLAELRNLRHK--------AVNF--SKSE--TILNGMKYFKVKMYPIEDFTESINF 210 Oikopleura di... XP_001771126 150 DLVAQllGVLSRLRFSSITER---YFTELN-LRRS--------YDTV-RSETL--SLIHGMRYLKLEMTTSAGLNAATSF 214 Physcomitrell... XP_001743412 237 AAEIV--GLLSEVAFTTVSERlvqYISELE---------------DS-SVAQM--TVISCLKYLRIKLYPAAALNNCFHF 296 Monosiga brev... XP_002679110 235 FAEII--GLMSVKWFQKISDN---FLE------QA--------SARL-EYKYEaaSFIRSLKYLKIRLSKPAEVNESVDL 294 Naegleria gru...
Q7SEI5 587 LTSLGKLFND-S---HGQ-KVKAAFCQVLEMLVLPIAATA-SsNDLAYPK-------WKEVVTTITPRLAH-MFMRPRH- 651 Neurospora cr... Q553W1 292 INSYLEFFKNnR---IKG-DLRRAISEILASILRPLTEEK-FkPELSYTE-------WIHTVKELYEYISKkTKKT-KD- 357 Dictyostelium... XP_002112298 233 MQDCAAFFNE-A---RNR-DVRHAMAAMMVELLVPVAGMA-K-REVNVPA-------MKNFVEMLYFNALD-LAKKSRH- 296 Trichoplax ad... CDJ01184 323 LHELGQYFLE-V---KEK-EIRHAMTCLFVEILLPVAAVV-R-HEVNIPA-------LKNFVDLLYNPAFE-LANKKKH- 386 Echinococcus ... CCD81486 285 LQELGQYYLE-V---KEI-EIKHVLSDLFVEILLPVAAVA-R-QEVNIPA-------LKTFVENLYPTSLE-LANKKKH- 348 Schistosoma m... XP_004346655 533 MNECGKFLLD-I---KKQpELKNAFADMFVELLLPVAAVA-K-SELNVPG-------VRNLVDLLYKDVYD-MAKKHKH- 597 Capsaspora ow... CBY19391 211 LKELGDYFHD-AidnKDP-KLQMCLAKITSEILEPLAENI-N-NEVNVPV-------LRHFVDSLYPSVLE-LAKRKNFq 278 Oikopleura di... XP_001771126 215 ITKANPLDGS-Pt-kKKA-ELHHAVCNMLSSILVPLAECK-K-GAWPPTGgdqalslWYDAVFKLRGQLNLwMDKQSKH- 288 Physcomitrell... XP_001743412 297 LQQCCELFLS-C---KKS-ECKHAWALLFVELLVPVAAHI-A-KEVNLLM-------VRKFVVKMYDATAE-SFKKSKH- 360 Monosiga brev... XP_002679110 295 MKKMTDFFGK-A---KKS-EIKRAFAESLANMLSPLAEFEyK-NGIDYRD-------WLAGLKNLLSIAKK-MCRKASY- 359 Naegleria gru...
Q7SEI5 652 -WT---YSFALTATMLCADVPENFGSQWMQLIYPLNSKLQ-DR--MTRP--LCLQAISRLLWTYLYR--T--N-DS-VAN 716 Neurospora cr... Q553W1 358 -VL---TSFPLLSILLCCLDKESFLKQFWGLMDSFIKC-K-DK--AIRP--YALESAQYLLECYLTK-----YsEQ-PEE 421 Dictyostelium... XP_002112298 297 -VS---VIFPLVTVLLCISQKSFFLSNWGAFLTMCLANLK-HKvvTTQR--IALESLYRSIWVYMIR--I--NgED-NNN 364 Trichoplax ad... CDJ01184 387 -AL---ALFPMVTCLLCVSTKVFFLNNWPPFMSLCLSQLK-NR--DLGQ--VSVESLFRLLWVYVVR--I--KcEK-HAD 452 Echinococcus ... CCD81486 349 -IP---ALFPLVTCLLCVGTKSFFLNNWTNFLSICLSHLK-NR--TSKValVSLQSLSCILWVYIVR--I--KgEK-HTE 416 Schistosoma m... XP_004346655 598 -TV---SFFPLTAALLCLSQKKFFMDNWHHFLAHCITNVK-SK--EFAVikVSMDAIYHLIWVYVVR--F--KcES-NSA 665 Capsaspora ow... CBY19391 279 nFT---WVARLVQLLLAVSQKQFFLNHWSIFLQCCLSIVK-TK--TTAT--VSLECVSRLVWVYCIRhgH--A-DA-NAT 346 Oikopleura di... XP_001771126 289 -VI---VGYPLVTLLLSLGDPQTFIDSFGNHLDNLYKLLK-DK--MLRS--MALDCLHRVLRFYLNV--YaaS-QQ-QEK 355 Physcomitrell... XP_001743412 361 -VAlkqAYLQLLTALLCISQADFFQQHWESVLNAAISNLKaAK--QLQD--AALDAIYRLVWVYMVR--I--K-GE-GQK 429 Monosiga brev... XP_002679110 360 -LN---TAFPFRAAVLCLNPKAVFIAPFKEFLTDIFRLCK-DK--GTKL--MGLDCLLHTLGYYLKI--A--N-ESdQST 425 Naegleria gru...
Q7SEI5 717 STRKLDEVVKIALPNTK-R-AFSAADLSVTEPLVQIIRLIGYKYPDYCFRNIIFPLVNA-DQ----FASNkdlKIE--FL 787 Neurospora cr... Q553W1 422 VYERLHQLVSHIFPTGHaK-KLTMSASDPLDVFVDIVCVIASTRIDFAFEKIIFDLLRGgDPkelyISNS---------- 490 Dictyostelium... XP_002112298 365 TNSRLRTIMEALFPRGS-R-NAV-PRNMPLNIYVRIIQFIAQEKLDFAFKEIISDLLGV-NK----ISKQ---FV----I 429 Trichoplax ad... CDJ01184 453 TQNKLLSIVNGLFPKG--S-KSVLPKNVSSTVFVKIIHFIAQEKLDFAMTEIIFDLLGV-NR----LQKL--------VL 516 Echinococcus ... CCD81486 417 TQTKLHTIINSLFPKN--Q-KIILPKDAPINIFVRIIQFIAHEKLEFAMKEVIIERLGV-NG----LQKT---LV----- 480 Schistosoma m... XP_004346655 666 TKSRISSITDVLFSKGS-R-T-LTPREAPLEVFVNIIRFIAREKLDLAVEDVIYELLSV--------KKP---ANV--TL 729 Capsaspora ow... CBY19391 347 TTSRLTLITKTLFPVGA-R-HTI-PKNQQSIHFVRILSYIASIKLELAMAT-IEDLLGV-AA----NKTT---NPErvQI 414 Oikopleura di... XP_001771126 356 IWLYLNSIATMLL-TNL-K-KGSLTQDVQHDKLVDFCVTIADAYLDFSMNHMILELLRT-EL----S------------- 414 Physcomitrell... XP_001743412 430 TEAKIKFVLDSLFPPG--S-KTIICRDASPLIYVRILQFIAHERSDIVFRFILHE-IGA-DR-------P---NSL--NL 492 Monosiga brev... XP_002679110 426 VIEILSKTIALLLSGKK-VpPSIPALDNIYDATVDVIVMVANNRMDYAMKNMVIKNL---DL----DSSS--------SC 489 Naegleria gru...
Q7SEI5 788 DPDRMVVGIHAFLAVM---------ADLEKG-EHgMPPFPL-----NYS-----Ysaslmdrisifsvlahphsslaatp 847 Neurospora cr... Q553W1 491 --ERMIIGLRAVMLI--------------DQ-AGtNPLTPK--------------------------------------- 514 Dictyostelium... XP_002112298 430 NPERMTIGLRAFLVIA---------DQLEQK-DD-PPPMPS-----Tig------------------------------- 462 Trichoplax ad... CDJ01184 517 TPERMNIGLRAFLLIA---------HGLQQK-DG-EPPMPQ-----NQPlagcgGgg----------------------- 557 Echinococcus ... CCD81486 481 MPERINVGICAFLLIA---------HGLQQK-EG-EPPMPQqcigaGGV-----Ggg----------------------- 521 Schistosoma m... XP_004346655 730 APERMMVGFRAFFAIC---------EGLVAK-SA-EPSFPR-----SSP-----Rtlmgtls----------------sv 772 Capsaspora ow... CBY19391 415 CVERQRIGLRAFVAIA---------NSFQQR-E--KPKLPP-----T--------------------------------- 444 Oikopleura di... XP_001771126 415 --EAKVIGLRALLAVV---------SSPSHHrYG-ADTFGV-----EDL-----Hssaissl----------------rg 456 Physcomitrell... XP_001743412 493 NPERMIIAIRAAVAIA---------NQAQSK-EE-QPSMPlm-------------------------------------- 523 Monosiga brev... XP_002679110 490 LPETVYLALRAFLAIAevndmkkisSILGTD-EK-TSEFPWvh------------------------------------- 530 Naegleria gru...
Q7SEI5 848 algvEEESLSKPVQISVLS-------------------------------------------------DTV--------- 869 Neurospora cr... Q553W1 515 ----MLSFSNSPTQSSPTS-------------------------------------------------TPP--------- 532 Dictyostelium... XP_002112298 463 ---mLPSGNLLRTKKSYLN-------------------------------------------------TTL--------- 481 Trichoplax ad... CDJ01184 558 ---pYSSVHPRGSGNVRRSfhgttld------------------------------------dalcerLGI--------- 589 Echinococcus ... CCD81486 522 ---fRQAVIKRSFHGTNLN-------------------------------------------------EAL--------- 540 Schistosoma m... XP_004346655 773 lgssLVALLASPTGAAASTlarspmfrrlsdsdmlgrglggsggspnqgggnpavapipyiddatakeAGV--------- 843 Capsaspora ow... CBY19391 445 --------TYRPSGNTIRG-------------------------------------------------KNKflhtplfde 467 Oikopleura di... XP_001771126 457 tstsWSHASGSANSDTALG-------------------------------------------------HNI--------- 478 Physcomitrell... XP_001743412 524 ---fERASAMGGTGTSNAT-------------------------------------------------ELR--------- 542 Monosiga brev... XP_002679110 531 ---kLLDRTQSRSSNETEA-------------------------------------------------DDL--------- 549 Naegleria gru...
Q7SEI5 870 -------K-------------------------------------------------D--------------------Y- 872 Neurospora cr... Q553W1 533 -------S-------------------------------------------------E--------------------Ss 536 Dictyostelium... XP_002112298 482 -------T-------------------------------------------------Etgake----------lgigpY- 494 Trichoplax ad... CDJ01184 590 -------R-------------------------------------------------P--------------------Y- 592 Echinococcus ... CCD81486 541 -------Gsll-------------------------------------------giqS--------------------Y- 549 Schistosoma m... XP_004346655 844 -------G-------------------------------------------------S--------------------Y- 846 Capsaspora ow... CBY19391 468 qarlaglD-------------------------------------------------K--------------------Y- 477 Oikopleura di... XP_001771126 479 -------G-------------------------------------------------P--------------------Y- 481 Physcomitrell... XP_001743412 543 -------S-------------------------------------------------QrllttsfltpeaaaqsglasY- 565 Monosiga brev... XP_002679110 550 -------EkdftqsvrmsspfssyrtlsasfaskassfygtnflaktdklldavglyQ--------------------Y- 601 Naegleria gru...
Q7SEI5 873 ---------------------------------YSRFCEILGKIAIICDNTFGGQAALDekf----kdEKFNSPgpKTPM 915 Neurospora cr... Q553W1 537 svsggskvravrrqrygtlnikkvaptsliepyLKNLSILLSQILISLDSTFGMLLTSNqtkplsellEKMrpp------ 610 Dictyostelium... XP_002112298 495 ---------------------------------YYGIRKALDCILRALDAQIGRSMSMI--------------------- 520 Trichoplax ad... CDJ01184 593 ---------------------------------LVPVRKAFEAILRLLEPQVCRSIMPP----------KQGAP--I--- 624 Echinococcus ... CCD81486 550 ---------------------------------LVPVRRAFEHILRQLDTQVCRPMMLP---------KQEVTQ--KE-- 583 Schistosoma m... XP_004346655 847 ---------------------------------FATILNLFGATLRALDAHIGRGMVMT---------NVLLQS--K-PL 881 Capsaspora ow... CBY19391 478 ---------------------------------LPTVQRALWQLMLTLHNHVGYDYLIT---------KSQ--------- 506 Oikopleura di... XP_001771126 482 ---------------------------------IPKVRSALGSIIKSCHAVFGTLLLTA---------TKITT------- 512 Physcomitrell... XP_001743412 566 ---------------------------------LDPLRKQLAAILTQLDALIVQPYLL-------------------TRS 593 Monosiga brev... XP_002679110 602 ---------------------------------QEEISSKLSAILKQCMQVYGNFLQSN---------H-------TKPL 632 Naegleria gru...
Q7SEI5 916 TDTFKFsRRDDQQsAYEQKQAFYELFHVAVEALPRCLSVDIPFNT----LINLLCTGTAHVQSNIARSSAQSLKA--IAR 989 Neurospora cr... Q553W1 611 ------------------gySCLELLKIAISVIPIAFPTKIIPQD----LVVMLSKFLIHLDRGVSEKASIVLTQl-MAS 667 Dictyostelium... XP_002112298 521 --NGQLlHKEVDD-LISEGKAKIELFRTCVAAIPRCLPEGMTKLE----LVNMLSTLSVHVDNELRSFAISSLQTl-LLH 592 Trichoplax ad... CDJ01184 625 --------KDDDA-APNDRKPKIDLLKTCVNCIPRLLPYEMSRTE----LIELLARVSLNVDEEIRMMAQQTMVNliIES 691 Echinococcus ... CCD81486 584 ---------FDEL-MTADRKPKLDLLKTCVACIPRLLPIDMTKQE----ILEILAKVCLHVDEDVRKMAQQAMANl-IVE 648 Schistosoma m... XP_004346655 882 GEVFN-----------AERRPLLMLYKTCLAFVPRFLPGGMTIQE----LIDLLARTTIHLDNELRSAAYAALKKl-ISD 945 Capsaspora ow... CBY19391 507 -------KFEDIS------QEKIDLLTLCVSAIPRILPEGFRSYKnrsqILRIISQLTIHQSSMVVEQALRSLDGi-ITE 572 Oikopleura di... XP_001771126 513 -----------EP-ATKEKSQGWLVFRWALKCVPHLIPEQWQAEK----LTEIIPQYAISVDTGVREEAIQVLFRt-VRD 575 Physcomitrell... XP_001743412 594 GDEVSTvH---AQ-LLTQHRRLLELYRNALLAVPRFFDLAHPTTD----VIDFVLHGTIHVDAEVRRLASTVLQCm-LRN 664 Monosiga brev... XP_002679110 633 HENLSK-----------DKYASLRVAVTAISCIPRILPSEFTKKE----LCDMLCRFVVHQYGDIRDVSWETMLQl-LDY 696 Naegleria gru...
Q7SEI5 990 -QSHAQQVTMGFARFIFNFDDRYSTMSDGGMLGPGHIEKTLMLYVELLHIWI 1040 Neurospora crassa Q553W1 668 rPDIRPQIIYGLGRFALYLSDKQSNl----------ISIVLEKKRELLELWa 709 Dictyostelium discoideum AX4 XP_002112298 593 fPDWTEIVFKGFVNFI---------AKEVPATNTEIVHNSLRLLYQLLTNWK 635 Trichoplax adhaerens CDJ01184 692 -PAYRQRTIQAFIQFIQKY---------VPDTAPHQLDSCLKTLHTLLVNWK 733 Echinococcus multilocularis CCD81486 649 lPAYRVKTIQVFIQFI---------QKNVADTSPHQLDSCLKTLFHLLNNWK 691 Schistosoma mansoni XP_004346655 946 fPHLRDDVVKGFVHFI---------VTEIPDSCPLIFEGALRMLIQILCHWn 988 Capsaspora owczarzaki ATCC 30864 CBY19391 573 lPEYREDVIAIYCTFI---------LTEIHDSHEMSIDTAVTHLTGLVEKWt 615 Oikopleura dioica XP_001771126 576 lPQSRFAVMRGMANFILRIPDDYNLL----------IHSSLGRLVQLLHAWR 617 Physcomitrella patens XP_001743412 665 hPGQRASLMQRLVGFF---------VHTVPFGETSSFEVAVKILIYTIRQWt 707 Monosiga brevicollis MX1 XP_002679110 697 hTDLRPVLVHSFAEMIMAIDDFRSDL----------LKSVLKKFLFLLEKWI 738 Naegleria gruberi strain NEG-M
Jiyao W et al.(2023). "The conserved domain database in 2023.",