Conserved Protein Domain Family
zf-SAP30
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pfam13866: zf-SAP30 (this model, PSSM-Id:290577 is obsolete and has been replaced by 404707)
SAP30 zinc-finger
SAP30 is a subunit of the histone deacetylase complex, and this domain is a zinc-finger. Solution of the structure shows a novel fold comprising two beta-strands and two alpha-helices with the zinc organizing centre showing remote resemblance to the treble clef motif. In silico analysis of the structure revealed a highly conserved surface dominated by basic residues. NMR-based analysis of potential ligands for the SAP30 zn-finger motif indicated a strong preference for nucleic acid substrates. The zinc-finger of SAP3 probably functions as a double-stranded DNA-binding motif, thereby expanding the known functions of both SAP30 and the mammalian Sin3 co-repressor complex.
Links
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Statistics
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PSSM-Id: 290577
Aligned: 13 rows
Threshold Bit Score: 107.502
Created: 29-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q7PXY4        18 ADQICCL--L------DDGER--CRKQAGNASYSKRIQKTVTQRRLKLSIDSHARHIYICDFHKARIQCARTK-RRR-RD 85  African malaria...
Q28IA6        38 SGQVCCL--R------EEGER--CNRPAGNASFSKRIQKSISQKKVKIDLDKTARHLYICDFHKNLIQSVRNR-RKR-KG 105 western clawed ...
Q28H91        22 FGQTCCL--I------DGGER--CPRPAGNASFSKRVQKSISQKKLKLDIDKSVRHLYICDFHKNYIQSVRNK-RKR-KT 89  western clawed ...
XP_002403592  24 HNQVCCL--L------DDAER--CTRPAGNASYSKRIQKTVAQRKLKLNIDPSAQHIYICDYHKGVIQSVRTK-RKR-KD 91  black-legged tick
XP_002422687  17 SDQICCL--V------DDNER--CKRPAGNASYSKRIQKTVTQRRLKLHIDNLAKHIYICDYHKGVIQSARTK-RRR-KD 84  human body louse
EKC40291     121 HDQICCL--I------DNSER--CNNSAGNASYSKRIQKTVQQRKLKLARDDRVSHIYICDYHKNVIQSVRSK-RKR-KD 188 Pacific oyster
XP_006012059  21 lGQFCCL--V------EDGER--CSRTAGNASFSKRIQKSIYQKKIKLEVDTAVRHLYICDFHKSFIQSIRNK-KKR-KG 88  coelacanth
XP_002009595  17 TDQTCCL--I------DDMER--CRNQAGYASYSKRIQKTVAQKRLKLSSDPSAQHIYICDYHKERIQSVRTK-RRR-KD 84  Drosophila moja...
XP_004927779  23 SDQICCL--V------DDGDR--CRRPAGNASYSKRIQKTVALRRLKLNIDGQARHTYICDYHKTMIQCARTK-QRRtKD 91  domestic silkworm
XP_001628074  15 SEQICCL--V------EDGNR--CKLTAGNASYSKRIQKTVAQRKLKLSLDVNARHIYICEHHKNMIQSVRSK-RKR-KE 82  starlet sea ane...
EFX89220      20 HDQHCCL--IefdqmiDDGER--CPRMAGNASYSKRIQKTVQQRKLRLHMDSSARHIYICDYHKSLIQSVRVRqRKR-KD 94  common water flea
XP_003383626  14 REELCSL--L------ENGER--CTNKAGSGVFTKKM-KSLAQKKQKLYPDSTASHNRICDHHRTFVHSLRNK-RKR-KD 80  Amphimedon quee...
XP_001894978 194 AKACCCLatL------TGGKAiaCGRPAFGIWFSNKLRQKALKKNLPFAYNKGRGHWYTCLFHYRVIMHEP-K-LKPnEK 265 Brugia malayi

Q7PXY4        86 SED 88  African malaria mosquito
Q28IA6       106 SDD 108 western clawed frog
Q28H91        90 SDD 92  western clawed frog
XP_002403592  92 SED 94  black-legged tick
XP_002422687  85 SED 87  human body louse
EKC40291     189 SED 191 Pacific oyster
XP_006012059  89 TDD 91  coelacanth
XP_002009595  85 SED 87  Drosophila mojavensis
XP_004927779  92 SED 94  domestic silkworm
XP_001628074  83 SED 85  starlet sea anemone
EFX89220      95 SED 97  common water flea
XP_003383626  81 SEE 83  Amphimedon queenslandica
XP_001894978 266 YEA 268 Brugia malayi
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