Conserved Protein Domain Family
BCIP
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pfam13862: BCIP (this model, PSSM-Id:290573 is obsolete and has been replaced by 464002)
p21-C-terminal region-binding protein
This family of p21-binding proteins is important as a modulator of p21 activity. The domain binds the C-terminal region of p21 in a ternary complex with CDK2, which results in inhibition of the kinase activity of CDK2.
Links
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Statistics
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PSSM-Id: 290573
Aligned: 188 rows
Threshold Bit Score: 103.81
Created: 30-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q4Q875       334 LVTVDFGVFDMEASNVDGLLHLMDQLCP-DRMNEVDRDELGLALYESP-FTSVVRLqnnge--datgE---E-------- 398 Leishmania major
Q384C3        86 VVDVDFGVFDIREQDVNAIMHLMDQFCP-DRMNEVDREDLGTAFLKSP-FTCIVKIsndyvcnddiaS---Sggeeeggv 160 Trypanosoma brucei
XP_002126595  29 kVDVDFEGFPLSDSDFDGIRQLLTQLLS-S-SVDINLSKLTESLIGQNfVGTVLKQsetgs--eaasP---E-------- 93  vase tunicate
EFO24603      35 ELVFDFEAYPMCGGDKEGLVNLLTQIF--LRA-DVDVKQMADILVEQSpFGCVYRPa---------eEfmdE-------- 94  eye worm
CDP97600      38 ELVFDFEAYPICDDDKEGLVNMLTQIFL-R--VDIDVKQMADILVEQSpFGCVYRPs---------eEf-mD-------- 96  Brugia malayi
CDJ04763      30 LVELDLEGFPPQSEDRDGIIQLLRQHIP--KASNVNLGELADYIIAQGsVGTVVKNg---------sS---E-------- 87  Echinococcus mu...
CDS33121      17 FVKLELEGFSPEGEDRDGIIQMLKQLLP-KTANL-RFASLADYIIGRDkIGTVVKYs---------dY---E-------- 74  Hymenolepis mic...
CCD59180      46 IFNLELEGFPPDISDRDSITILLKHLFP--NNCVINVENLAEYIVTQDsIGTVVKPtcdde-sdddsD---D-------- 111 Schistosoma man...
XP_001566238 328 LVTVDFGVFDMKASDVDGLLHLMDQLCP-DKMNEVDRDELGLALRESP-FTSVVRLqnnge--datgE---E-------- 392 Leishmania braz...
EGT55652      85 VMDFDFEAFEPSEDDRDGIINMLTQTFLrTDI---DMKGMAEEIIAKNpHGIVLKQaed------ddE---T-------- 144 Caenorhabditis ...

Q4Q875       399 AQEf--------YGLSSVLDVahGQSLyPAALRPLYGLL---QQ--RVWRQAAP---GI---PPTdILtsvvDG--Gpaa 457 Leishmania major
Q384C3       161 EEDv--------YGVASVLDLahDSRL-----GSLLNLL---KT--DVWRTVSP---GV---LPTeLL----TT--Leek 210 Trypanosoma brucei
XP_002126595  94 EDEv--------FALVTCLPIipQDELqKSIVKHFIS-K---CK--SSSASSETk--KE---FTK-IL----QAcaE--- 146 vase tunicate
EFO24603      95 DDDgi------vYGVLSMLNLgtDQ----KFQTDIWTLL---KT--RAQKYSVDk--KIssiLDN-LS----TS--E--- 147 eye worm
CDP97600      97 EDDeg-----ivYGVLSMLKL----DTdQKFQTDIWALL---KA--RAQKYSVDk--KIssiLEN-LS----TP--K--- 150 Brugia malayi
CDJ04763      88 TDTvedddddivFSLTTVITLcgSVVSrSSIVSELRDFLqscIS--RAESSSPDy--KT---LLK-VL----MG--E--- 150 Echinococcus mu...
CDS33121      75 AEDddde--divFSITSLINLfePDITqYPIIADLCKFLesfIN--SSKSSNPDa--ST---IVK-VL----TG--A--- 135 Hymenolepis mic...
CCD59180     112 DNIv--------FAVTSVVDLshESAVkHSVVKDLRNFI---LEgvNASKNVPMr--CK---VEE-LL----DK--D--- 165 Schistosoma man...
XP_001566238 393 EQEf--------YGLSSVLDVahGLTLyPAALRPLCELL---QQ--RVWRQAAS---GI---PPTdILtsvvDG--Grva 451 Leishmania braz...
EGT55652     145 EEDfm------iYQLCTTLPLneKKDDaPKFIKDIFTYL---LN--RAKKSASSeiyKK---IQE-IQe----------- 198 Caenorhabditis ...

Q4Q875       458 sSrakCLLLISEYIRNIPLELTVQILEDVLDRLDAAGqqekKKIqaqtageAMATHehpifaTHpsmFAVLAKVQRATDA 537 Leishmania major
Q384C3       211 tGrakCVFLVGEYIRNVPLELTSHILTDLAKRFEETFgrrvEENlkskqgkDVIHA------TFpciFAVLSKIQRATDS 284 Trypanosoma brucei
XP_002126595 147 -KgepTGFLINERFINVPSQAALPMFEKLFSELESAK----NSNh-----kANYNF------TH---YVIICKICRDFAT 207 vase tunicate
EFO24603     148 -SdirVGLLINERLLHFPATIASPAFKSLINDLEKS-------G-------TQYLF------SH---IILILKIRIADSN 203 eye worm
CDP97600     151 -SdirVGLLINERLLHFPATIASPAFKSLANDLKKF-------A-------AQYRF------SH---VVLILKIRIADKD 206 Brugia malayi
CDJ04763     151 -AsekPALLINERLVNLPPAVSAEAVAVLPQEIQTLP----EEE-------RP---------TH---LIILTRAVKs--- 203 Echinococcus mu...
CDS33121     136 -SserPALLINERYVNLPAEVAEKSVSSLLDEINVLP----ENE-------KP---------TH---IIVLTRAIKs--- 188 Hymenolepis mic...
CCD59180     166 -TdckSFLLINERFENLPLSICAEAVSALPSEFKSSN----LLP------------------TH---LFILSWAYSEEAK 219 Schistosoma man...
XP_001566238 452 sSrakCLLLVSEYIRNVPLELTVQILEDVLDRLDAAGqregKKSsvqtaeeAMATHehpifaAHpsmFAVLAKVQRATDA 531 Leishmania braz...
EGT55652     199 aGdgfTGLFVSERLLDFPSDVVPQIFDSIRTDLAGFD----------------KKY------KN---IIYIQKLRIMENE 253 Caenorhabditis ...

Q4Q875       538 PvtlpkhavpsssgggsegagsggdaaavahrkhhnggsH-------------NTKkgsegangsvsggatgapdsplDL 604 Leishmania major
Q384C3       285 Psadtga---------------------------easaaD-------------RKEgrdkslpqkrkkrtvtqqheelDM 324 Trypanosoma brucei
XP_002126595 208 ------------------------------------------------------------------------------QD 209 vase tunicate
EFO24603     204 Gn-------------------------------------KerngastpnisrnRKKltkaqkk--------rvaasaiAN 238 eye worm
CDP97600     207 Snkernea------------------------sasdvpnK-------------RKKltkaqkk--------riaasaiAN 241 Brugia malayi
CDJ04763     204 -----------------------------------------------------------------------------kDT 206 Echinococcus mu...
CDS33121     189 -----------------------------------------------------------------------------pDS 191 Hymenolepis mic...
CCD59180     220 Dn-------------------------------------D-------------KK------------------------- 224 Schistosoma man...
XP_001566238 532 PvtlpkhavpllpghgaggagsgdnvaaavhrkdhngrsR-------------NTKkrsegagaggrssamgapesplDL 598 Leishmania braz...
EGT55652     254 Ganqsanksgs-------------------sssssappkK-------------KGKmgkaekk--------raaaaalAN 293 Caenorhabditis ...

Q4Q875       605 THYIFWREEDNIL 617 Leishmania major
Q384C3       325 KRYVFWREEDSVL 337 Trypanosoma brucei
XP_002126595 210 SDTMYMNAEEEIF 222 vase tunicate
EFO24603     239 AKVIYDNCEEELL 251 eye worm
CDP97600     242 AKVIYDNREEELL 254 Brugia malayi
CDJ04763     207 DELIYIQPEMEIv 219 Echinococcus multilocularis
CDS33121     192 SELIYIQPEMksv 204 Hymenolepis microstoma
CCD59180     225 --YEFAYPEIEFI 235 Schistosoma mansoni
XP_001566238 599 RHYIFWREEDSIL 611 Leishmania braziliensis MHOM/BR/75/M2904
EGT55652     294 AEIEFDNSEDRVL 306 Caenorhabditis brenneri
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