Conserved Protein Domain Family
CABIT
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pfam12736: CABIT (this model, PSSM-Id:289505 is obsolete and has been replaced by 463686)
Cell-cycle sustaining, positive selection,
The 'CABIT' domain (for 'cysteine-containing, all- in Themis') is found in a newly identified gene family that has three mammalian homologues (Themis, Icb1 and 9130404H23Rik) that encode proteins with two CABIT domains and a highly conserved proline-rich region. In contrast, Fam59A, Fam59B and related proteins from mammals to cnidarians, including the insect Serrano proteins, have a single copy of the CABIT domain, a proline-rich region and often a C-terminal SAM (sterile-motif) domain. Multiple-sequence alignment has predicted that the CABIT domain adopts an all-strand structure with at least 12 strands, ie a dyad of six-stranded beta-barrel units. The CABIT domain contains a nearly absolutely conserved cysteine residue which is likely to be central to its function. CABIT domain proteins function downstream of tyrosine kinase signalling and interact with GRB2.
Links
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Statistics
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PSSM-Id: 289505
Aligned: 43 rows
Threshold Bit Score: 119.021
Created: 15-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9CU24        17 LPRQVEVTQGRY-SGSlenlsFS---------KGDIITVVDLEP--VF-VRAEL--K--Dgd------qvL--DVVTIPL 71  house mouse
XP_002428357  31 LPAVVKIIKGQYgGLGvp--sLPcp-----glQSTALLVSAGKR---KkIVAQA--V--KlkegrrvigvG--PRLAIPD 94  human body louse
XP_002593555  42 LPQLVKVTYAECeAPG-----LS---------KNEILLLHFTYT--SKkVMAQS--L--Skegg---ivvG--PELNIPL 96  Florida lancelet
XP_012223607  31 LPAVIKITKGQYgGLGvp--tLPap-----slQSTALLISAGRR---RkIVAQAvkI--Kegr----rvvGvgPRLAIPD 94  Argentine ant
XP_002593552  34 LPLLAMVRQPDPdIP------LQ---------QGDVLLLHSSYS--SHkVLAQC--M--Drqgg---rlvG--PMFNIGY 87  Florida lancelet
XP_002593551  33 LPTLVKVTQSDRrSQ------LS---------KDLVLLVNSSFS--EEkVLAQS--L--Eretg---ktiG--PLVSIPA 86  Florida lancelet
XP_002594517  39 LPQIVKLTGENGaD-------FP---------DGALLLLVGLRKdnSRfVVARC--MagDrdr----tmvG--PWLSIPL 94  Florida lancelet
XP_002593550  34 LPVFVTVAREDPqAD------LA---------KDDIYLLRSSYS--ERdVFARK--V--Hrtsg---rlyG--PLLTIPL 87  Florida lancelet
XP_002407933  31 ePQVGRVIRGQYrH-------VGvpslsspslSSVLFLSPLGPR--LR-ISAQC--VkfKenrr--vstiG--PRLAIPD 94  black-legged tick
XP_970327     31 LPAVVKIIKGQYgG-------LGvptlpspglQSSALLVSAGKR--QK-IVAQA--VkiKegrr--lvcvG--PRLVIPD 94  red flour beetle

Q9CU24        72 RYEGNFQLMADPV----S----FETVAD-----LTRSV---R-Lpqsp----------vaprSPPRFQNSIPISADNLPM 124 house mouse
XP_002428357  95 SYDGFFEILSEEG----RavrcMESVSE-----LAKRR---P-Eagcl--------------vrepVRAIVARYEDDGSI 147 human body louse
XP_002593555  97 AYPGRFELLQNQS----Nvk-vFESLEEvinedLQSKM---PvVrllv-----------eedILDSELPPAGVASPEMGM 157 Florida lancelet
XP_012223607  95 SYAGYFEILSEEG----RavrgIESVSE-----LSRRC---P-Degal--------------vretVRGIACRVDDESGI 147 Argentine ant
XP_002593552  88 SYPGTFEVMYGEG----Rv---FDSVQE-----ILKAVeddP-SrvfkvlveedvvlsdkerVPKSVAHNLGMYSDRKHA 154 Florida lancelet
XP_002593551  87 SYTGTFRLLA-PQ----S----FQTVQE-----VVDSQ---P-Fsgtftvee--dmkwkkqrLPDSVQQMMISELGESGL 146 Florida lancelet
XP_002594517  95 SCKSRFVRMSNKQttkdR----FQGVKE-----LAEYL---P-Nkvia-----------teaVSE-------LGSSGNSS 143 Florida lancelet
XP_002593550  88 KHPAKFVIFKKVF---------YNGVSE-----LLRAN---P-Fpesfrvee--nvtwresgKSQEAFELLGLLSMKMSQ 147 Florida lancelet
XP_002407933  95 SYKGWFEILSEDG----RssrcFESVAE-----LLRRS---P-Etclv---------------reaVKAHLAHPDDP--E 144 black-legged tick
XP_970327     95 TYSGYFELLSEEG----RavrcIESVSE-----LARRR---P-Eegcl--------------vretIRGVQARGDAD--A 145 red flour beetle

Q9CU24       125 ----K--------LRK-----------------GETLSLIGFQE------------------------------SRGRr- 144 house mouse
XP_002428357 148 ----Tadg--artIAV-----------------GETLFLAGEAT------------------------------LGGAkg 174 human body louse
XP_002593555 158 ----AttgprqplCKK-----------------GDVIMIVSAQP------------------------------REQPap 186 Florida lancelet
XP_012223607 148 vvpeGtr-----tLAA-----------------GETIVTAGEVA------------------------------LPGRgr 175 Argentine ant
XP_002593552 155 ----C---------RR-----------------GDILLPEGKAV------------------------------RLAGhk 174 Florida lancelet
XP_002593551 147 ----Kgkfp-ktlVRR-----------------GDLLSMRGILN------------------------------PTNGep 174 Florida lancelet
XP_002594517 144 ----Sqi-----lVNA-----------------GEEIRCLGIEG------------------------------VHTKpp 167 Florida lancelet
XP_002593550 148 ----Nqskd-gghVYAkdmskmkpkvinmspvvGDCLTVIDKTEpiqdseevvldmsqgggkkktstlkrikssFKGKke 222 Florida lancelet
XP_002407933 145 ----Tvtdk-trtLPL-----------------GETLVVIREVR------------------------------ASLGrl 172 black-legged tick
XP_970327    146 ----Vvpeg-artVPA-----------------GEVLVPAGEVL------------------------------VSGSkg 173 red flour beetle

Q9CU24       145 ---------------------------------------------lLQCKvlrKKPPLTVLLPMDCRGHFLE------CQ 173 house mouse
XP_002428357 175 --------------------------------------------ryLRCL---DSRGDTILLGLEQKGRFSAia--keDN 205 human body louse
XP_002593555 187 vqhvqeipevhkkglghklraqfkgkgrrtshtenkepevqrpkmiFTCs---NQDGDLVTLPGDLKARFTLkp--leFE 261 Florida lancelet
XP_012223607 176 ---------------------------------------------fLRCv---DCRGDSILLGMDQRGRFSAla--reDN 205 Argentine ant
XP_002593552 175 gmgrlasfgsakewkrt----------llrkkerskidgkeevyeyLVCs---NQLGEVLYLPAKHRSTFTSv-----RP 236 Florida lancelet
XP_002593551 175 qgednplngdaggqq--------------kkgskkskkkgkplpayVICM---NQDGEIMCIPSYCSGRFSTva--lrNT 235 Florida lancelet
XP_002594517 168 skrq------------------------------------lhsnwtLACL---NENNDYLTLSLDCSAKFLAvasvaaEQ 208 Florida lancelet
XP_002593550 223 srktkt---------------------------------vaqpmgyLVCA---NQTGGLVCLHTDCTGRFSAy------- 259 Florida lancelet
XP_002407933 173 rst---------------------------------------hgrfLRCL---TSGGDTVYLAAESRGKFSPia--keGN 208 black-legged tick
XP_970327    174 --------------------------------------------ryLKCL---DSKGDTILLGLEQRGKFSAla--reDN 204 red flour beetle

Q9CU24       174 DDRFYS---IDTIVR---WKMLAGRKRTVRVQA--RHhpkllgplvpeHFRGHLVLYPCFSVTANL-------------- 231 house mouse
XP_002428357 206 ISGVHT---ARNLLCk---RLPMTVRLVHGTVPrgLKtp--------nHFIPELRLLSTFEEEHVF-------------- 257 human body louse
XP_002593555 262 SGTTYT---VENVIDn--FKLPQDVKLVHGDCPgdDDe-----------FTGYVRLFHTYRDEVIV-------------- 311 Florida lancelet
XP_012223607 206 ISGVHT---AKALLSk---RLPLTVRLVHGQPPrgLKss--------sQFVHELRLLSTFEEEHVF-------------- 257 Argentine ant
XP_002593552 237 TSSEHSqlqVKDIVEk--TKLPIDVKLLSGEIPrgDF-----------QSTPFFRLLDAYKESVVL-------------- 289 Florida lancelet
XP_002593551 236 SGPTFT---LKDIVDdadIDLPADVLYVDGEAFmeDe-----------HFTGLVKLLTSYEKKLVV-------------- 287 Florida lancelet
XP_002594517 209 SPEEET---IDKLASd--T-FPITVLQTNGETPkfCQd----------TFTGIFRLVQAREDRMIS-------------- 258 Florida lancelet
XP_002593550 260 LPEQYT---MEELLEn--FKLPGDVEVVGGKLPddHP-----------NFGGRLRLLSFCTETFLVvnglpkqgevtgag 323 Florida lancelet
XP_002407933 209 ISGVHT---VRTLLC---KRFPLMVRLVHGRPAsgLKt-------------sELRLYGIEREDYIM-------------- 255 black-legged tick
XP_970327    205 ISGVHT---AKNLLS---KRLPLTVRLVHGTAPrgLKsp--------sHFVPELRLLSVFEEEHVF-------------- 256 red flour beetle

Q9CU24       232 --L-------------GE--------TRVSIPSDLDISVTEIArlDRKPRTTMR 262 house mouse
XP_002428357 258 --Alplq-----ketnSV--------IALPLAASLKLQLTKNEeqLKGLKEFQR 296 human body louse
XP_002593555 312 --Gt------------SVqddgqisqVEFSINTDIQFSPADLElsENKEILRLF 351 Florida lancelet
XP_012223607 258 --Alplq------regAV--------VALPLAAPLKLVKARNEevlrsmqeftr 295 Argentine ant
XP_002593552 290 --Aslikg----dkvrAA--------MELSTSALLRFCLADTSsrEYAELLIRL 329 Florida lancelet
XP_002593551 288 --Asilee----dggfSS--------VEFGVDCGVKFAPADPDdpKNRDFLKRa 327 Florida lancelet
XP_002594517 259 --AcllrtgangavlyQF--------LELPAATTSAVLLPEGMvkDEVSYNLLL 302 Florida lancelet
XP_002593550 324 vqAa------------VV--------TELSIDSDVRFTPARKSspQNVELLKLL 357 Florida lancelet
XP_002407933 256 --Ampli-----kdapPV---------TIPQSAFLKLQAPKNAdvLVTLPEYar 293 black-legged tick
XP_970327    257 --Alplq-----kdahSV--------TALPLAAPLKLLRARNDdqLKTLpefhr 295 red flour beetle
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