Conserved Protein Domain Family
TPPII
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pfam12580: TPPII (this model, PSSM-Id:289357 is obsolete and has been replaced by 463636)
Tripeptidyl peptidase II
This domain family is found in bacteria and eukaryotes, and is approximately 190 amino acids in length. The family is found in association with pfam00082. Tripeptidyl peptidase II (TPPII) is a crucial component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. It is an amino peptidase belonging to the subtilase family removing tripeptides from the free N terminus of oligopeptides.
Links
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Statistics
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PSSM-Id: 289357
Aligned: 59 rows
Threshold Bit Score: 190.074
Created: 15-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q09541        832 APTKSIDVSPSISLKSLVVSLKPQS-A-KVEp-lGPRDMFLtS-GLQINRLLLTYQLKVQKPSEVQLQLAgLTPYLYESP 907  Caenorhabditi...
XP_001751904  808 AALGSETLAPSATLKKVRVAYRPVE-A-KVAplsALRDKLT-D-GRQINALTLTYKFSLAEGGNVTPRIPiLNGRMYDNE 883  Physcomitrell...
XP_002960433  877 SPLSSERLTPSITLTRVRTPYRPSE-W-KLEalsAERDNLP-D-GRQIHGLTLIYKFNLSEGGKYTPRFPaLNGRVYDNE 952  Selaginella m...
XP_009536065  787 SSVETETLAPKVSFTKYVQRIRPKT-A-EITplsSSRDQFP-D-KRQVYQLILTYPFTKKEAGKVVPHLPlLNGRLYESP 862  Phytophthora ...
XP_001781503  807 AALGTEQLSPSATLNKIRIPYRPVE-A-KIAplsATRDRLT-D-GRQINALTLTYKFFLPEGGDVTPRLPiLNERMYDIE 882  Physcomitrell...
CBN77615      847 APLSMQELLPSASLNKWCTLVAPSK-G-TISa-lGPRDVTP-D-GRQTYGLLLEYSFKQADAGEVTPRLAaLNGYLYDSA 921  Ectocarpus si...
XP_002179315  801 SDLADETINPVAKLTKWLTPLRPKAgA-AIKp-mGPRDTLP-SrNKEIYELVLTYEFTQEEKGSLIPRALgMQGILYESV 877  Phaeodactylum...
XP_004988338  774 CTLGKVTLQPKVQYTTLERVIFPVR-AgTVRplrEERNVLI-D-GSHMYALELSYSFSLSDKANVYPVLPgVSDFLYEGD 850  Salpingoeca r...
XP_001750537  780 NTFAPFTMKPSGKLETLRKSLRPTQ-H-AIIcksGPENTMF-N-GKQTHALELTYELNLAEKAKVVPRLAqLSEVLYESA 855  Monosiga brev...
XP_002952779  961 twsRATRVKPEAKLTSVHIPLRATE-S-SLEpmtAARDALT-D-GRVVYRLLLTYKTTVSEPGKYKPCLPlINKQIYDSP 1036 Volvox carter...

Q09541        908 VDCVLFQIFG-ANKSFVGASSSYPDRWtqKLEKGDYTIQAQIRYPDDQVLQGMKELPLLVHVKL--GNKIS--VDLAASA 982  Caenorhabditi...
XP_001751904  884 FESQFYMLCD-SNKRVLSMGDVYPVGV--KLSKGDYTLLLHIRHDNMNHLEKLKKAVLLLDRDL--EDK----LGFSSHI 954  Physcomitrell...
XP_002960433  953 FESQFYMIYD-ANKRVLSMGDVYPKGV--KLSKGEYTIRLLIRHDNSSFLEKLKKAVLFIDRGLeeKNYIK--LSSYSNI 1027 Selaginella m...
XP_009536065  863 FEAQLMMIFD-DKKQYLGCSDAYGDETm--LKKGSYVVRAQVRHEDVSKLEKLKQMVLLLNHEI---KEIP--ASVFGHQ 934  Phytophthora ...
XP_001781503  883 FESQFYFLCD-SNKRVLSIGDVTPL-Ta-RLSKGDYTLLFHIRHDNTRYLEKLKKTVILLERDL--EGKVSikLSFSSHI 957  Physcomitrell...
CBN77615      922 YEAQMCMIFD-SNKKLLAVNDCWPEAt--KLAKGEHTVRVHVRHPDQSALKRLKSHPLMLIRKL--SSSLA--VPVHATV 994  Ectocarpus si...
XP_002179315  878 FESQIMLLFD-GEKKYLGVADAFPS-Fl-TVPKGSVTIRMQIRHDDPSKLENLKDMPIWIERKL--EKEIA--LSVYSSR 950  Phaeodactylum...
XP_004988338  851 MHNQLWMIFD-DNNRILQRGDAFPNRYktDLKKGSYTIVYQLRHSSKSKLEDMKESHILLIQKL--KSPLS--ASVYSVQ 925  Salpingoeca r...
XP_001750537  856 AESQLMVILN-EKKFPVLFADAFGRYSt-ELDKGKYTLRAEIRHDDTAWLEKYKDLALNLDIKI--K---A--VDVAVDK 926  Monosiga brev...
XP_002952779 1037 LESQLLLVHDgTTKQLLSVQDADPESVt--LKKGEVLIRLALRHDSQELLDKMRGLPLVLKRSLd-GGGVA--VPVYGSR 1111 Volvox carter...

Q09541        983 SDATL--GKECKfa---gKALLPNQEMTVYAMNIADdkLP 1017 Caenorhabditis elegans
XP_001751904  955 DGVIT--GGGPFk----sALLAAGETRPFYIVAPTDdrIP 988  Physcomitrella patens
XP_002960433 1028 DGAIT--GTNGLk----pTVLAPGEKRAFYVASPGDdkAP 1061 Selaginella moellendorffii
XP_009536065  935 DDVAL--GGKPLd----kRSLPTGKYVPLFVGEPAHdkLP 968  Phytophthora sojae
XP_001781503  958 DGAIT--GAEPFt----nVQLAAGESRPFYIVAPADekIP 991  Physcomitrella patens
CBN77615      995 IGVST--AAKAPp----aLCLDKGHSAAYFFAEPNQekLP 1028 Ectocarpus siliculosus
XP_002179315  951 EGVMS--GAATFr----kRVLHKGSGCSVFFGEPASskLP 984  Phaeodactylum tricornutum CCAP 1055/1
XP_004988338  926 PG-TT--AQQSFs----kMDLVRGRSVPVFVEPVKAskLP 958  Salpingoeca rosetta
XP_001750537  927 TPAIV--QGG-Sv----hMRLPTQQRTSFFVEPPTDasLP 959  Monosiga brevicollis MX1
XP_002952779 1112 RDAILaaGGSSSagpageVLLRAGDVAPLWLGPAPEdkLP 1151 Volvox carteri f. nagariensis
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