Conserved Protein Domain Family
DUF3652
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pfam12372: DUF3652 (this model, PSSM-Id:289166 is obsolete and has been replaced by 463554)
Huntingtin protein region
This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with pfam02985. This family is in the middle region of the Huntingtin protein associated with Huntington's disease. The protein is of unknown function, however it is known that a polyglutamine (CAG) repeat in the gene coding for it results in the development of Huntington's disease.
Links
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Statistics
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PSSM-Id: 289166
Aligned: 14 rows
Threshold Bit Score: 31.4143
Created: 15-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_002053984 2511 RRLAAQSSPATRSSIYERllqgelagdedqdelrTMLLKDLEY 2553 Drosophila virilis
XP_002137040 2817 RDLNASTDAALRCELLEVlch-----------saRCMLQETIF 2848 Drosophila pseudoobscura pseudoobscura
XP_002070517 2710 REVNASTT-GVRSELLEVltm-----------tgRCLLQDTIF 2740 Drosophila willistoni
XP_002105244 3362 RELNASLNPSLRCELLDLlds-----------vaRCILQDTIF 3393 Drosophila simulans
XP_001955065 2703 RDLNARLDPGPRCDLLELldr-----------vsGCILQDTIF 2734 Drosophila ananassae
XP_002137040 2550 RRLTAQSGPAARAIIYERlldgdlaggedqdamrTLLLKDLEC 2592 Drosophila pseudoobscura pseudoobscura
XP_001981440 2450 RRLSAQSGQPARNVIYERlvegdlaggedqdalrTLLLKDLEC 2492 Drosophila erecta
CAJ87484     1335 DGLMASGQGSASHVIPAM----------------QPIIHDIYV 1361 vase tunicate
EKC42935     1383 DGIMASGLQPVSHAIPAL----------------RPVVFDLFL 1409 Pacific oyster
CAA89024      237 DGIMASGRKAVTHAIPAL----------------QPIVHDLFV 263  human
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