3EPZ


Conserved Protein Domain Family
DNMT1-RFD

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pfam12047: DNMT1-RFD (this model, PSSM-Id:288868 is obsolete and has been replaced by 463444)
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Cytosine specific DNA methyltransferase replication foci domain
This domain is part of a cytosine specific DNA methyltransferase enzyme. It functions non-catalytically to target the protein towards replication foci. This allows the DNMT1 protein to methylate the correct residues. This domain targets DMAP1 and HDAC2 to the replication foci during the S phase of mitosis. They are thought to have some importance in conversion of critical histone lysine moieties.
Statistics
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PSSM-Id: 288868
Aligned: 20 rows
Threshold Bit Score: 99.7407
Created: 29-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3EPZ_A         67 YEALPQHKLTCFSVYC-KHGHLCPIDTGLIEkn----iEL----F----------FSGSA-KPIY-------DD-DPSLE 118  human
Q01G69         17 RRSIPMRVLDEYEFRD-KFEETRVVSTHGSKps----mVL---------------VVGKA-RKLEgdg-edgDP-RELLG 73   Ostreococcus ...
Q010T3        121 NDGPLVRLLDDFELIReETTPTGELVRRQVKfr----eEL----F----------EDAESaSTLRvrg-hmrVV-SDERL 180  Ostreococcus ...
O74560          7 EKKRKTDLIEQVCVTN-KAGELVDLE--DVLey----gPY----S----------LTGILsSEKD-------EQ-EPLFD 57   Schizosacchar...
Q6Z978          7 DLEPQLKAVENYYFVD-DNDVPVSFDVLPFQfd----aAE----G----------VASFK-KDVYl-------------- 52   Japanese rice
Q8IKY8        794 vsNNFLDSINEYHIET-SNNKRNIME----Kng----eDI----F----------ISDIK-EDKDnnilikqED-FEKKK 848  Plasmodium fa...
Q9M0S8        365 TRDLPCRTLHNWALYN-SDSRMISLEVLPMRpc----aEIdvtvF----------GSGVVaEDDGsgf-cldDS-ESSTS 427  thale cress
XP_009117317   84 DEPRQTRRLTDFILHD-EYGVPQPVAMVEIg-------DI----F----------VTGVI-LPSG-------EC-DDKEK 132  field mustard
XP_001415894   51 GQTLPMRVLDEYEFRD-KFAEGKAVSVHGSRpn----rVL----V----------LGRAR-KLEGgehglpsEV-LAAPL 109  Ostreococcus ...
XP_001419868  215 AHGGIIRLLDDFELVQ-CETTSASCDTRARRrcikfheDL----FenpdvaatirISGRL-REVR-------SDaLAPLG 281  Ostreococcus ...
3EPZ_A        119 G---GVNGKN----LGP------INEWWITGFD--GGEk-ALIGFSTSFAEYILXDPSPEYAPIFGLXQE-KIYISKIVV 181  human
Q01G69         74 Ra--LVPRETpphaLKLv----dVNDWTIRYGE--DE---PEIWLVTPRAWYKLLDPSPRYEKYATVMLR-RARFTNAVV 141  Ostreococcus ...
Q010T3        181 RparEEEGESveveLKG------IVGYQYSFTA--PIDl-RGFYVVTTFAAYKLMNPKSTYATLYERGFQmRFDLARRAA 251  Ostreococcus ...
O74560         58 E----SIVLGysikISP------V--WTYNLKDvpEKEt-MSIWIVTPQRRYGILSPSSEYKAIYEQISE-KNRLFYLIK 123  Schizosacchar...
Q6Z978         53 ---rGFTDGGlqkvYKQ------VVAWKLVLDG--DSP--EIAVLSTEGSWIALLKPRPS----YEETIR-SVLITVEML 114  Japanese rice
Q8IKY8        849 Kk--KILNNKikkhLNSmnvriiIKEWYIDYVLypNSIp-YIYVISTNNNRYRLDKPLAQYFHIFTKVRQ-KFEITTRIL 924  Plasmodium fa...
Q9M0S8        428 Tq--SNVHDGmnifLSQ------IKEWMIEFGA--EM---IFVTLRTDMAWYRLGKPSKQYAPWFETVMK-TVRVAISIF 493  thale cress
XP_009117317  133 Gk--GVKCDG----FGR------VENWSISGYD--DGY--PVVWFSTELADYDCGKPATSYKKMYDYFYQ-KAFASVEVY 195  field mustard
XP_001415894  110 T---PQDKPPhalkLME------VHDWTIKY----GGDe-PELWLVTPRAWYKLLNPAPRFEKYVTVTTR-RANFTNAIV 174  Ostreococcus ...
XP_001419868  282 Dd--DEEDGGrqieVGN------IVAYQYSFVA--TVPeiRGFYLVTSTATYKLLKPKATYSMLYNRSFQmRYDLARRTA 351  Ostreococcus ...
3EPZ_A        182 EFLQSN----S----DSTYEDLINKIETT 202  human
Q01G69        142 KALMKN----W----NMGLDEGLDRILSV 162  Ostreococcus tauri
Q010T3        252 RALPRT----S----RVTFDTLLPELETR 272  Ostreococcus tauri
O74560        124 TKFKDD----MisgtLEDYDNYIEVLKEK 148  Schizosaccharomyces pombe 972h-
Q6Z978        115 HFVRRR----Ptd-sEKDMWDHLYGVFER 138  Japanese rice
Q8IKY8        925 KTLQVY----P----NMSYNRLISYLTly 945  Plasmodium falciparum 3D7
Q9M0S8        494 NMLMRE----Srv-aKLSYANVIKRLCGL 517  thale cress
XP_009117317  196 KRVAKSaggdS----GVSLDELLVAVSRS 220  field mustard
XP_001415894  175 RALVKN----W----ELSLEEGLDIILGV 195  Ostreococcus lucimarinus CCE9901
XP_001419868  352 RALPRS----P----RSSLESIIPELLTR 372  Ostreococcus lucimarinus CCE9901
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