pfam11577: NEMO (this model, PSSM-Id:288434 is obsolete and has been replaced by 431942)
NF-kappa-B essential modulator NEMO
NEMO is a regulatory protein which is part of the IKK complex along with the catalytic IKKalpha and beta kinases. The IKK complex phosphorylates IkappaB targeting it for degradation which results in the release of NF-kappaB which initiates the inflammatory response, cell proliferation or cell differentiation. NEMO activates the IKK complex's activity by associating with the unphosphorylated IKK kinase C termini.The core domain of NEMO is a dimer which binds to two fragments of IKK.
Jiyao W et al.(2023). "The conserved domain database in 2023.",