4DHJ,4FJV


Conserved Protein Domain Family
Peptidase_C65
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pfam10275: Peptidase_C65 (this model, PSSM-Id:287276 is obsolete and has been replaced by 431191)
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Peptidase C65 Otubain
This family of proteins conserved from plants to humans is a highly specific ubiquitin iso-peptidase that removes ubiquitin from proteins. The modification of cellular proteins by ubiquitin (Ub) is an important event that underlies protein stability and function in eukaryote being a dynamic and reversible process. Otubain carries several key conserved domains: (i) the OTU (ovarian tumour domain) in which there is an active cysteine protease triad (ii) a nuclear localization signal, (iii) a Ub interaction motif (UIM)-like motif phi-xx-A-xxxs-xx-Ac (where phi indicates an aromatic amino acid, x indicates any amino acid and Ac indicates an acidic amino acid), (iv) a Ub-associated (UBA)-like domain and (v) the LxxLL motif.
Links
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Statistics
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PSSM-Id: 287276
Aligned: 22 rows
Threshold Bit Score: 206.753
Created: 15-Jul-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4DHJ_I        36 DEQKSVPL-VATLAPFSILCAEYDNetSAAFLSKA---------TELSEV--YGEIRYIRGDGNCFYRAILVGLIEIMLK 103 Caenorhabditis ...
Q0V4T6        82 EPEATGPL-VGERQSSAAITTEYQNa-DPIYRIKT---------AALPGK--YAFFRTCRGDGHCGWRAIAFTYFEALLR 148 Phaeosphaeria n...
Q2H586       170 APHTQGPL-VGKKTPSSAIMEQYADa-DAIYVQKT---------MALPQT--YSDYRPIQGDGNCGWRAIGFGYFETLVK 236 Chaetomium glob...
Q7SI56       234 yqpelnglpVGDKLPSTAITEEYAKa-DPVYVQKT---------RSLPAV--YSHYRPMLGDGNCGWRAIGFGYFETLIK 301 Neurospora crassa
Q4PBQ0        28 ESTSHQAL-ISAVEPIEVLEKEYAA--NRAFLGKI---------KWLKEEagFIGLRRAKGDGDCFYRAFAFAFIYKIMM 95  Ustilago maydis
Q7XPN5       230 DSCKTRDK-----KPIVDLADEFE---NNTIKKKI---------TLLSEK--YDFFRPVDRDGSCFYRAFIFSYMERIVA 290 Japanese rice
Q5KB39        20 ENTSDKPL-VSTPVPLSVIREEYLKg-SQQIVKKL---------DYLQENg-WDQVWRARGDGDCFYRSFTLAYLLRILH 87  Cryptococcus ne...
A0E9B0        29 EIEAQDPFiITQPIELQILESEYLQ--NQGFLQKI---------QKIRQS--YPQFRRVRRDGSCFYRAVLFRIFEYIIE 95  Paramecium tetr...
XP_001596545  20 QPALVGPL-VGDKMRSTAITEEYAKa-DPIYVSKT---------SALPQK--YSHYRPILGDGNCGWRAAVFSYFETLLR 86  Sclerotinia scl...
XP_001464809  21 vahypllslslplNKESMIVKEMEHd-D-AYLAQTlslfgaspvSTKQYD--FDSIRYSRRDGNCFYRCAGFRLCELIVE 96  Leishmania infa...

4DHJ_I       104 DRA------R--LEKFIASSRDWTRTL-V---ELGFPDWTCTDFCDFFIEFLEKIHSGVHTEE-----A--VYTILNDDG 164 Caenorhabditis ...
Q0V4T6       149 VGDv----nK--FGDEEARLNSLGNLL-D---HIGYSRDLWIDFADGAFDLMRKLADSLQAMDgqapdI--LLQTFNDFN 216 Phaeosphaeria n...
Q2H586       237 SGSk----aR--IEAERQRLEGLNSLI-En--VGEFSPYVSQDFVDETLALLSKMAALVGHREqa-mtE--LREAFNTPS 304 Chaetomium glob...
Q7SI56       302 LGNk----aQ--VDGERERLESLNEYI-Qh--HGGFDPMVFVDFVEETDELLKRISDKLNVPEea-msE--VMHAFTDAE 369 Neurospora crassa
Q4PBQ0        96 MKDr----pM--HHFTVKHVESTLQLL-K---HAGFDEEVVTDFYEPLKNLLNRMYSTDPESQelnehA--LLQAMNEPE 163 Ustilago maydis
Q7XPN5       291 MQDdleriiE--VSRIGERIGKYKQAY-ArfgSFGIPQEEFLKALSAFEQLINLIEkgv-------avE--QLYQIDETD 358 Japanese rice
Q5KB39        88 SPEpd---vE--ANLAYDAIQRALPAM-E---QCGFQKDIYEEFLDPLLALIRSFAESDETTAne--yS--IVQALQDPE 154 Cryptococcus ne...
A0E9B0        96 SKDq----qI--LDKFSTIIANSKADL-T---AVGYEQIVIDDFYDEIMKQIKLCPNNITIQ------G--IVDAFCNKV 157 Paramecium tetr...
XP_001596545  87 MGN------RgqVDEELARMMSLNNLLtT---AGGFDAWLFEDMVEETTSLLRDVADLMDTSIqa--aEslILDRFNNSE 155 Sclerotinia scl...
XP_001464809  97 HPD------R--AAEYVALLKSREESL-S---RL--FGLFVFDFTDALAEILKGVADKTITSVa----Q--VYNRFISDD 156 Leishmania infa...

4DHJ_I       165 SANYILMFFRLITSAFLKQNSEEYAPFIDEg--------MTVAQYCEQEIEPMWKDADHLAINSLIKAA----GTRVRIE 232 Caenorhabditis ...
Q0V4T6       217 ESMSIITYVKLLASAWVQTHADEFRHFVPM---------GDVKAYCANNIEPTKCEADNIGIAALAEALikpaGFGLEVW 287 Phaeosphaeria n...
Q2H586       305 ISDSVMYHFRMLASSYLKGHRETYSAFVTGg--------TGVDGYCLEVLERHNVEIDHLGLILLANVLlkdaGFVLEVA 376 Chaetomium glob...
Q7SI56       370 KSNAIIYHLRLLASSWLKENRGSHEAFITTd--------ESVEKFCQRVIEVPNIEIDQLGLQALVSILlkpvGFVLRVA 441 Neurospora crassa
Q4PBQ0       164 QSNSIVVYLRLLTSAFLKLNADEYTPFLFSldtssdagpPDMASFCANQVEAIGKEADHVQITALSRAL----KVSLDVA 239 Ustilago maydis
Q7XPN5       359 ITKNSLRFLRFLTEIEICTHEDHYKGFLLTad------ySSVFEFCQVEVRPENAEASNEQMKALVEAL----GIPVLVE 428 Japanese rice
Q5KB39       155 RSNYIVVSLRLITSSYIRTHADLFSPFLFSptt---flpLSTEEFCRQEVEPCGKEADNAQIMALAEAM----NAGVRVA 227 Cryptococcus ne...
A0E9B0       158 TSDYLIMYMRMMTSGYIKANSFLFEGYIET---------GTVELFCQQEVDPIDREADQMQIIALQNYL----QIPIRIF 224 Paramecium tetr...
XP_001596545 156 TSNAIVYHCRLLASSWLKANPQNYQGFIPDg--------GGIDQYRKDWLEPPNQEIDHLGMTLLIDVLlkpaGFAVEIV 227 Sclerotinia scl...
XP_001464809 157 GA-YVLAALRYLISAYLQEHEEEYEPFVSGlg------yGTVRDYCNAEVELVDHESDNVQLAAFAKAF----NVCIKVY 225 Leishmania infa...

4DHJ_I       233 YMD------------------------------RTa---APNGGWHYDIPsd--------------dQQ----------- 254 Caenorhabditis ...
Q0V4T6       288 YLD------------------------------RS----PGEEINRSFYA-----------------DPtdhqg------ 310 Phaeosphaeria n...
Q2H586       377 YLD------------------------------RS----PGPEVNTYRIPeean---------grhpSE----------- 402 Chaetomium glob...
Q7SI56       442 YLD------------------------------RS----PGSEVNTYSFPeeai---------sqptSP----------- 467 Neurospora crassa
Q4PBQ0       240 YLSpqqappqtpl----------deefpaeqlhQStensSDPTCRASASIpvpgndaq--rtrsaaeHPdrcdvvr---- 303 Ustilago maydis
Q7XPN5       429 NLDttsetdtpilnqhfiyprpeseegtmlgplNSheivSPESSGYHAARgelqnqpstsgsstnssTEalglqsigtss 508 Japanese rice
Q5KB39       228 YLD------------------------------RSe--vGGKTINWVEFGkd--------------tSE----------- 250 Cryptococcus ne...
A0E9B0       225 YLD----------------------------------------GNVSTFDatifq-------ipedaDS----------- 246 Paramecium tetr...
XP_001596545 228 YLD------------------------------RS----EGTQVNSHMFQaedpn--------gqptNP----------- 254 Sclerotinia scl...
XP_001464809 226 ALD------------------------------RNa----GNNITEYSFNged------------ndAE----------- 248 Leishmania infa...

4DHJ_I       255 --------IAPEI------------TLLYRPGHYDVIYK 273 Caenorhabditis elegans
Q0V4T6       311 ----msipNAHML------------RLLYRPGHYDILYK 333 Phaeosphaeria nodorum SN15
Q2H586       403 --------LGPII------------HLLYRPDHYDILYV 421 Chaetomium globosum CBS 148.51
Q7SI56       468 --------LDPVI------------CLLYRPDHYDILYp 486 Neurospora crassa
Q4PBQ0       304 --feveggQITEIg-----------TMLLRPGHYDLLVE 329 Ustilago maydis
Q7XPN5       509 tpnerdgkGDRTIndlspaerrrlaILLYRPGHYDILCP 547 Japanese rice
Q5KB39       251 --------NARPL------------TLLYRPGHYDVVTK 269 Cryptococcus neoformans
A0E9B0       247 --------KSIFI------------NLLYRPGHYDILYP 265 Paramecium tetraurelia
XP_001596545 255 --------AGPII------------YLLYRPGHYDILYK 273 Sclerotinia sclerotiorum 1980 UF-70
XP_001464809 249 --------DRLVV------------GLLYMPGHYNLLGR 267 Leishmania infantum JPCM5
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