Conserved Protein Domain Family
DUF2152

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pfam10222: DUF2152 (this model, PSSM-Id:287225 is obsolete and has been replaced by 431148)
Uncharacterized conserved protein (DUF2152)
This is a family of proteins conserved from worms to humans. Its function is unknown.
Statistics
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PSSM-Id: 287225
Aligned: 5 rows
Threshold Bit Score: 825.646
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q17ID2  13 RLKRT---FDGNIS---YRKLFaLLFVVAVFLLYIGPSFLRWL-------FGSDEPIKDHTGRCMDDRLTPFYLQQLEYN 79  yellow fever mosquito
Q29LN5  18 RLKRL---AEGTLSs--YRRLF-LLLLCVCTVFYMLPPIFRYV-------FLSAPEQKDPHSVCMDDRLTPYILQNYEFD 84  Drosophila pseudoobscura
O45086  13 RIENMdfeSKMRMVrryPKRRLaIIIGVVLFVIFIFS---RGT-------SSGTSFTKQH--QCSAEKLKLWEKEIDEFD 80  Caenorhabditis elegans
A4IH88   6 RLKVF----PGLLSsswARRVLaVSGFLVIIYWYIFSGSLFRS-------FWYAGPPRGISGACLHGQTMQWKALAEKGD 74  tropical clawed frog
Q2KHV9   6 RLKGL----PGLLSsswARRLLcLLGLLVLLLWFAGSGARRAAgglqllpWPHGEPGAAEPSACLEAATHAWRSLRERGE 81  cattle
Q17ID2  80 VNIRH--QPIFPQEYDAV--PYV-GNGMFGLEIQADaNLHIF-RGRALLQPVNFHPIVSVAAGGMGTHREATVVEYLSGV 153 yellow fever mosquito
Q29LN5  85 ANIRHvsPSKLPGERDFT--PYI-GNGYIGLEIAHDaSLNIK-HGRAMQLPIRFQPIVSVAQQSVGVEKESTVVEYLTGM 160 Drosophila pseudoobscura
O45086  81 TGINN--QSV----------EFV-GNGYIGVDSFG--QLRVQeKNRVLDVETNFYPGLNIEIDGQQPVEVTKMTDFKNGI 145 Caenorhabditis elegans
A4IH88  75 VVMVS-----FPGEETKMqgPTMvGNGHIIVDVGKN-NLWVSsLS-VLFHLTNYSPLTFVKSVGALAETHATAIFFKEGL 147 tropical clawed frog
Q2KHV9  82 AVLLG------PGV------PSLvANGFLALDVVAN-RLWVTpGEREPAVAPDFVPFVQLRPLSALPEAGESVLLLREGL 148 cattle
Q17ID2 154 VHRFQCFs---------------------------EGYFVSYQYYAHRTMPSVLVQEIQITNTKNQLVDVELVVPRIsDW 206 yellow fever mosquito
Q29LN5 161 VHRFQCF----------------------------PGYFASYTYYAHRTQPNVLVQELQITNTRNMIEDVELIMPRV-NL 211 Drosophila pseudoobscura
O45086 146 FKILRCFsm------------------------dgECACVTSQIWAHRTRPNYFVQLIQVSNPTKSTVRLNL-------- 193 Caenorhabditis elegans
A4IH88 148 IRTIRCLqmeas-------------------dsshDCVTVREDHFAHRSRPHVYVQKIHIANPSDRVVTFDISSQKPlTG 208 tropical clawed frog
Q2KHV9 149 LRRVRCLqlgtsgpgpaaagpgpasasglltgsgrDCVLLQEDFLAHRGRPHVYLQRIQLNNPTERVAALQTVGPTAgPA 228 cattle
Q17ID2 207 PTAVTRSVKLQHGstIL-----EYQVITGLIDVVStgndDKRIRVVCIVARKMPRVLTLKKRGTTKLELLLTINYSDAIP 281 yellow fever mosquito
Q29LN5 212 PRLSHRTLKLSEPasAGmvfynELDVLTGIVQPVAe--dPSKLIVVSIVKPQLDAKLQVRKRGTVRFVYPIAIHYSKPVA 289 Drosophila pseudoobscura
O45086 194 -SRLSSNWWAHSK--LG-----ELTVHQRQVARAS----------YAVVCTDAPGKVSVSQKREESFRFTCSI-ASKPTS 254 Caenorhabditis elegans
A4IH88 209 -ETFTTSVEKVQE---R-----QFLLSSGRV-SVE----DGKIILVVVATKKLVSRLQVSPKSDYDETVFSVVYASEPID 274 tropical clawed frog
Q2KHV9 229 PRAFTSTLEKVGD---H-----QFLLYSGRSPPVP----TGLVHLVVVAAKKLVDRLQVAPRTQLDETVLWVVHVSGPLN 296 cattle
Q17ID2 282 R----DKYAVYKETIEQQTIDAMNKVLQaae-----hgEHNAYYAFKRDHIKVWNSLWETGFHISTSKAENTLNGNDINA 352 yellow fever mosquito
Q29LN5 290 E----AQIKATVEANEQQATQAMIKLLQklgskaantgSSYSINTFRQEHIDVWADLWATGFTISTSKAEHSLNGDRINA 365 Drosophila pseudoobscura
O45086 255 E----------------EASRDAIRFFQ----------SGKDSKTLDSEHFDGWSKMHLTGFSVANSKAPNTLNGDRINA 308 Caenorhabditis elegans
A4IH88 275 P----GKVSDTFSKLRESAKKEMFELMH------------MKTEDLFHEHQQIWSDLFVSGIEMKKIKDLHTPSRDTINI 338 tropical clawed frog
Q2KHV9 297 PqvlkSKAAKELKVLQDLARKEMLELLE------------MPAAELLQDHQRLWAQLFSPGVEMKKITDAHTPSGLTVNL 364 cattle
Q17ID2 353 TMYAVISQSRAYEYE---VSSTVQKKQDIERALTYAEGCYDSYHTLQ-AENLW-KKTSNLEDLNGVVASWMLTLEKQGCH 427 yellow fever mosquito
Q29LN5 366 TMYAVLSQVRCFEFEemgTAVSSAKKEDIAKALTYAEGCYDSYHTLQ-AENLW-REMSTLQQLNSLVSSWMLTLEKQGCH 443 Drosophila pseudoobscura
O45086 309 TKYILMSNLRAPTIE---HGATLESVKPLENLARKSELCYTGHSNLLfPSRLW-QDWDTPTKLFELVNTWMLTFQKRGCN 384 Caenorhabditis elegans
A4IH88 339 TLYYMLSCSLAPLVD---PILSNEERDKMESFLNYADHCFTGHSTMH-AENLWpSSLSGITQLLQLWDLWKLTLQKRGCK 414 tropical clawed frog
Q2KHV9 365 TLYYMLSCSPAPLLS---PDLSHRERDQMESTLNYEDHCFSGHATMH-AENLWpGRLSSVQQILQLWDLWRLTLQKRGCK 440 cattle
Q17ID2 428 NLIKAGASGIVQAMVLSFGGFRFSNQHLELNIHPKYLHRDYDFRRLN-YGNM---THVNVSIAVREDNKAVLFVALDRSD 503 yellow fever mosquito
Q29LN5 444 NLIRAGASGVIQAMVLSFGSFRFSNQHLECNIHPKFLHRDFHFRRLN-YGNK---THVNVTIIVKDDNKAIIQVALDRSD 519 Drosophila pseudoobscura
O45086 385 NLLSTGAIGASQAFVQSLTASSYHDSHLEVALDAHDLHREMNFHGIPvYSNMgvvGTIRVDIKLDTENRPYFMVSSSS-- 462 Caenorhabditis elegans
A4IH88 415 SLVSAGAHGLMQGMLLSFGGLQFTENHLQFQSDPHVLHNSYSLRGVH-YNK----DLINLAVLLDKDEKPFLHVSVKFQD 489 tropical clawed frog
Q2KHV9 441 GLVRAGAPGILQGMVLSFGGLQFTENHLQFQADPDVLHNSYALHGIR-YKN----DHINLAVLADAEGKPYLHVSVESRG 515 cattle
Q17ID2 504 G--NYYACDAGCLDPPVQLGPS-KTI-FPVKLTEPLTSILYITSDKIHMEDLRHALHVKEVVEAPAHEHHVIALHKHGHS 579 yellow fever mosquito
Q29LN5 520 R--SYYACDGGCLDEPVLLTQS-RRH-FPVKLTEPLTAILYITEDKQHMEELHHAIHVKEVVEAPAHEQHLIALHKHGHQ 595 Drosophila pseudoobscura
O45086 463 ---QLFVCDGGCLDSPVSLGKT-PVQ-LPVKVTKPVTSLLYIAPSRRHLELLRNAIHVSEVGAAPAHEEEVIEMHRSGES 537 Caenorhabditis elegans
A4IH88 490 KlvKLYACEAGCLNEPVELTSEiRGHiFPVLVTQPLTPLLYISTDLTHLQDLRHTLHLKEIL---AHEEHMAKQYR---- 562 tropical clawed frog
Q2KHV9 516 QlvKIYACEAGCLDEPVELTSApQGHtFSVMVTQPITPLLYISTDLTHLQDLRHTLHLKAIL---AHDEHMAQQDP---- 588 cattle
Q17ID2 580 LGALPTLFWVSICVIIVVFHVFLCKLIVKEY-------CEPPDKFRYRYS 622 yellow fever mosquito
Q29LN5 596 LGGLPTLFWVSVCAIIIVFHIFLCKLIIKEY-------CEPSDKLRYRYN 638 Drosophila pseudoobscura
O45086 538 TGGM-TTFWVFVFVVVVAFHLVVAKIVWSEWrkgdmtpYNPYLRNRYSAR 586 Caenorhabditis elegans
A4IH88 563 --GLPFLFWFSVASLITLFHLFLFKLIYNEY-------CGPGAKPLFRSK 603 tropical clawed frog
Q2KHV9 589 --GLPFLFWFSVASLITLFHLFLFKLIYNEY-------CGPGAKPFFRNK 629 cattle
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