pfam09497: Med12 (this model, PSSM-Id:286572 is obsolete and has been replaced by 462818)
Transcription mediator complex subunit Med12
Med12 is a negative regulator of the Gli3-dependent sonic hedgehog signalling pathway via its interaction with Gli3 within the RNA polymerase II transcriptional Mediator. A complex is formed between Med12, Med13, CDK8 and CycC which is responsible for suppression of transcription. This subunit forms part of the Kinase section of Mediator.