pfam09079: Cdc6_C (this model, PSSM-Id:286205 is obsolete and has been replaced by 462672)
CDC6, C terminal
The C terminal domain of CDC6 assumes a winged helix fold, with a five alpha-helical bundle (alpha15-alpha19) structure, backed on one side by three beta strands (beta6-beta8). It has been shown that this domain acts as a DNA-localization factor, however its exact function is, as yet, unknown. Putative functions include: (1) mediation of protein-protein interactions and (2) regulation of nucleotide binding and hydrolysis. Mutagenesis studies have shown that this domain is essential for appropriate Cdc6 activity.
Jiyao W et al.(2023). "The conserved domain database in 2023.",