1EG3


Conserved Protein Domain Family
EF-hand_2
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pfam09068: EF-hand_2 (this model, PSSM-Id:286194 is obsolete and has been replaced by 462668)
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EF hand
Members of this family adopt a helix-loop-helix motif, as per other EF hand domains. However, since they do not contain the canonical pattern of calcium binding residues found in many EF hand domains, they do not bind calcium ions. The main function of this domain is the provision of specificity in beta-dystroglycan recognition, though in dystrophin it serves an additional role: stabilization of the WW domain (pfam00397), enhancing dystroglycan binding.
Links
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Statistics
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PSSM-Id: 286194
Aligned: 61 rows
Threshold Bit Score: 92.574
Created: 27-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1EG3_A        51 ADLNNVRFSAYRTAMKLRRLQKAL------------CLDLLSLSAACDALDQHNLK-----QNDQPMDILQIINCLTTIY 113 human
Q7QHZ2        19 EKYAGARYSTYRCAGKLHALQKAL------------HTSYIPFEMVHSILNRHQLNl---iDSAPSIKPGQLASVVHDVY 83  Anopheles gambi...
XP_012058338   9 QECNAIRYPSYRTAAKMQILHREL------------NMTHVQLELIAGVFERHRLSi---tENCVNLDPSEIEDVLSDIY 73  Atta cephalotes
XP_001851098  38 EKFATSKYSTYRCACKLFALQKAL------------FTNYIPFQTICTILERHRLNq---iDSAPSIKPSQLTAVLHDVY 102 southern house ...
XP_001963840  54 MKYGNYKYTVYRCASKFVALQKIF------------HTGKVPYKLVLAILERHGLRg----NLELMVPPFQLTSLIHDIY 117 Drosophila anan...
XP_001355193  43 VDYGKYKYTVYRCASKFVALQKIF------------HTSKIPYKLVLAILERHGMPassgsNLNLMVPPFQLTSLLHDIY 110 Drosophila pseu...
XP_012549889  41 SVYDDIKYAVYRIAFKIHALQKQI------------RVPPLRISS--GVFARHQLSl---sESSLSLDTTELEAVLADIY 103 domestic silkworm
EHJ71479      41 DEYNDIKYSAYRIAFKIFALQRSL------------KVPPLRISS--GVFARHQLSl---sETSLSLDTAELEAVLADIY 103 monarch butterfly
EFA06845      40 DDWNYVKYSKYRVGLKFRALQKAL------------FMEEVTLSTVMGVFAKHKLGm---nESSLCLESYDLEAVLYDIF 104 red flour beetle
EKC18153      46 DEYRDIRYAAYRTAFKIRHIQKRLkckypehahagqKVHHVKLEAMKEMFDCHGYPe----SCDTVIGCEELQELLTSVY 121 Pacific oyster

1EG3_A       114 DRLE--QEHNN--LV-NVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLC 162 human
Q7QHZ2        84 FAAArmGYFDElpARpNLDAASALLAGFLWAVFDPKRTTPVSVLELRQAFLLLC 137 Anopheles gambiae str. PEST
XP_012058338  74 FA----AQKESnfNF-DVDLVTKLATNYILNTFDKQNTGNILVFSVKVALVLLC 122 Atta cephalotes
XP_001851098 103 FAAEqlGYFAEltQQpDRDALISTLAGLLWSVFDPKRCNPLSVLELKQTFLLLC 156 southern house mosquito
XP_001963840 118 FACEklGHFAQesSF-QLETASELLANFFWNVYDPQRRHSISLLEIKITLILFC 170 Drosophila ananassae
XP_001355193 111 FACEklGHFTKtsSY-TLETATALLANFFWNIYDPQRRHSISLLEIRVTFLLLC 163 Drosophila pseudoobscura pseudoobscura
XP_012549889 104 FA----AEKDGlfDG-DVDFAVDLLINLLLNVYDvDRKEPIRVLAAKTLLIVLS 152 domestic silkworm
EHJ71479     104 FA----AEKEGlfTG-DVDLSVDLLINLLLNVYDGERKSPIRVLAAKTLLILLS 152 monarch butterfly
EFA06845     105 FA----ANKRNnkNI-DVDFAVELMQNFLYNIYDKERQVKIQVSSTKLALALLS 153 red flour beetle
EKC18153     122 QS----ADQAAniTIqQAEVFAQLLQNLVLNLFDVDRTGCLRVCSVKQVLIILt 171 Pacific oyster
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