Conserved Protein Domain Family
Creb_binding
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pfam09030: Creb_binding (this model, PSSM-Id:286163 is obsolete and has been replaced by 462659)
Creb binding
The Creb binding domain assumes a structure comprising of three alpha-helices which pack in a bundle, exposing a hydrophobic groove between alpha-1 and alpha-3 within which complimentary domains found in the protein 'activator for thyroid hormone and retinoid receptors' (ACTR) can dock. Docking of these domains is required for the recruitment of RNA polymerase II and the basal transcription machinery.
Links
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Statistics
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PSSM-Id: 286163
Aligned: 34 rows
Threshold Bit Score: 38.4419
Created: 13-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q09472       2007 Q--SGMPRPAMM---SVAQ---HGQ-------------------PLNMAPQPG--LGQVGiS--PLKP--G------TVS 2047 human
XP_007502633 1983 QfqGGMQRPAMM---SGGQ---AGQ-------------------PMNMAPQPG--LGQVP-AvgQPKQ--G------SLP 2026 gray short-ta...
XP_004913856 2062 smqPGMQRSPIM---SVPQ---QGQ-------------------PMNMNPQSGigQVPGA-S--QTKQ--G------SLP 2105 western clawe...
XP_011602062 2278 almsisQQQGAV---GGVQ---AGA-------------------ASGATGVAG--MVPPG----------G------NIP 2314 torafugu
CAG04516     2175 ppmNPQQRPGMMghmAPQQ---QPAvtqspqqqmnqpqpqpgnrGMMPGLGVS--GGPVG-L--PASI--AgaaasgNLP 2244 spotted green...
XP_008328477 2239 ggpmqqppqqgglpqgqlppqvqlqqqrmgapiqnpqqqqqpqqqqqwagqgmppqqrqammnqmghtammaaqqqqqqh 2318 tongue sole
XP_005448114 2213 QqpqpGNRGLMQa--------iGGA-------------------GGVPASLAAgsg------nlPQ-------------- 2245 Nile tilapia
XP_010780197  539 pqqrmmghmqqqqagipqqamnqqqgarglmqvmggaaglsgvsagvqnsivA--AAasg--nlPQ-------------- 600  black rockcod
XP_011603285 2178 qlqpvqqggggqlqptNQQwgaGGP-----------------------QQRPG--MMgh---maPQQQaaV------NQP 2223 torafugu
CAF95299     2155 aaarvhmdqpqggpqgmmvgaggglqqappqgqpqprpaapaaavsgaaGLPV--MVPpgg-niPQ-------------- 2217 spotted green...

Q09472       2048 Q--------------------------------------------QALQNLLRTLRSPSSPLQQQQVLSILHANPQLLAA 2083 human
XP_007502633 2027 Q--------------------------------------------AALQNLLRTLRSPSSPMQQQQVLNILHANPQLLAA 2062 gray short-ta...
XP_004913856 2106 Q--------------------------------------------AALQNLLRTLRSPSSPMQQQQVLNILHSNPQLLAA 2141 western clawe...
XP_011602062 2315 Q--------------------------------------------AALQELLRTLRSPSSPHQQQQVLNILRSNPQLMAA 2350 torafugu
CAG04516     2245 Q--------------------------------------------GALQELLRTLRSPSSPAQQQQVLNILRSNPALMAA 2280 spotted green...
XP_008328477 2319 pqaqghaallnmaqqqqqqgagmpggavpgptgipgagaagnipqAALQDLLRTLRSPSSPHQQQQVLNILRSNPQLMAA 2398 tongue sole
XP_005448114 2246 ---------------------------------------------AALQDLLRALRSPSSISQQQQVLNILRSNPTLMAA 2280 Nile tilapia
XP_010780197  601 ---------------------------------------------AALQDLLRTLRSPSSPLQQQQVLNILRSNPTLMAA 635  black rockcod
XP_011603285 2224 PpqqmnqqqpqpgnrgmmpglgvsggavglpasiagaaasgnlpqGALQELLRTLRSPSSPLQQQQVLNILRSNPALMAA 2303 torafugu
CAF95299     2218 ---------------------------------------------GALQDLLRTLRSPSSPHQQQQVLNILRSNPQLMAA 2252 spotted green...

Q09472       2084 FIKQRAAKYANS 2095 human
XP_007502633 2063 FIKQRAAKYVTQ 2074 gray short-tailed opossum
XP_004913856 2142 FIKQRAAKYASS 2153 western clawed frog
XP_011602062 2351 FIKQRASKYKgg 2362 torafugu
CAG04516     2281 FIRQRAARYqgg 2292 spotted green pufferfish
XP_008328477 2399 FIKQRASKYKGv 2410 tongue sole
XP_005448114 2281 FIRQRAARYQGA 2292 Nile tilapia
XP_010780197  636 FIRQRAARYQgg 647  black rockcod
XP_011603285 2304 FIRQRAARYqgg 2315 torafugu
CAF95299     2253 FIKQRASKYKgg 2264 spotted green pufferfish
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