Conserved Protein Domain Family
CTNNB1_binding
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pfam08347: CTNNB1_binding (this model, PSSM-Id:285538 is obsolete and has been replaced by 462440)
N-terminal CTNNB1 binding
This region tends to appear at the N-terminus of proteins also containing DNA-binding HMG (high mobility group) boxes (pfam00505) and appears to bind the armadillo repeat of CTNNB1 (beta-catenin), forming a stable complex. Signaling by Wnt through TCF/LCF is involved in developmental patterning, induction of neural tissues, cell fate decisions and stem cell differentiation. Isoforms of HMG T-cell factors lacking the N-terminal CTNNB1-binding domain cannot fulfill their role as transcriptional activators in T-cell differentiation.
Links
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Statistics
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PSSM-Id: 285538
Aligned: 18 rows
Threshold Bit Score: 199.234
Created: 26-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9W7C0         1 MPQLSg---gGGGGDpELCATDEMIPFKDEGdPHKEQIFAEIShseEEGDLAEIKSSLVNETEISPN-----SNSH---- 68  zebrafish
Q8JHX2         1 MPQLG-----SGGGD-DLGATDEMLAFKDEG-EQEEKIPENAF---TERDLADLKSSLVNESEGSGS-----PAAA---- 61  chicken
XP_007473463   1 MPQLGg---gGGSGD-DLGATDEMLAFKDEG-EQEEKIPQGGF---PERDLADLKSSLVNESEGAGSsg-qaGSGP---- 67  gray short-tail...
NP_001092656   1 MPQLDsggggAGGGD-DLGAPDELLAFQDEGeEQDDKSRDSAAg--PERDLAELKSSLVNESEGAAGdagvpGAGA---- 73  cattle
NP_989421      1 MPQMN-----SAGED-DLGASDEMISFKDEG-DQEEKIRESAF---TERDLADLKSSLVNESEVSSH-----PRVPeshp 65  western clawed ...
XP_003410440   1 MPQLSgg-ggGGGGDpELCATDEMIPFKDEGdPQKEKIFAEIShpeEEGDLADIKSSLVNESEIIPA-----SNGH---- 70  African savanna...
XP_003972447   1 MPQLS-----GGGGDpELCATDEMIPFKDEGdPHKEQIFAELShseEEGDLADIKSSLVNESESSPN-----SNSH---- 66  torafugu
XP_002596146  26 MPQLN-----GSGGD-DLGASDETISFKDEG-EQEEKSAENVS-----NDLSDIKSSLVNESESSQS-----GAVP---- 84  Florida lancelet
XP_011603100   1 MPQLN-----GEDGD-DLGANDELIAFKDEG-EHEEK--RNVS---AERDLDDVKSSLVNESETNSS-----SDSE---- 59  torafugu
XP_005458373   1 MPQLS-----REDGD-DLGASDELIAFKDEG-EQEEK--RNVS---AERDLDDVKSSLVNESETNSS-----SDSE---- 59  Nile tilapia

Q9W7C0        69 -DAa----------RQSQITPDSYhEKHRdhp--ddGKLQD-----LYSKGh-PYPSYPGYIMMTnmn------------ 117 zebrafish
Q8JHX2        62 -ADpe-------aiRRVQDPQRVYqEKLPdhmddagMKHQDp---gMYKGS--AYSGYPFLMLSD--------------- 113 chicken
XP_007473463  68 -GQte-------tlRRASNSQRLYqDKLPdal-eegLKAQDsssvgMYKES--VYSGYNLLVHYPangvsagtgagtgag 136 gray short-tail...
NP_001092656  74 -GArgeaevgaealGREHTSQRLFpDKLPesl-edgLKAPEct-sgMYKDT--VYSAFNLLMHYPppsga-------gqh 141 cattle
NP_989421     66 eAM-----------RRTQDAQLVYqDKLTdhm-edgVKHQDe---gMYKGS--GYPSYPFLMLSD--------------- 113 western clawed ...
XP_003410440  71 -EVa----------RQAQTSQESYhDKARehp--deGKHPDg---gLYNKGp-SYSGYSGYIMMPnmn------------ 121 African savanna...
XP_003972447  67 -Dg----------vRQSQI-PDSYhEKHRdhq--edGKLQD-----LYCKGh-PYSGYPSYSMMSnm------------- 113 torafugu
XP_002596146  85 -SE------------GSKPPLQSYpREd--------SRRGDe---gSKAESvpVVSRGPAYLTPGgvivs-------nmg 133 Florida lancelet
XP_011603100  60 -VPgd-------rrPKPGVDLERRaRHGQlldedvfRRRQDg---gLFHPS--PYVGYPFFMIPDlgn-----------f 115 torafugu
XP_005458373  60 -ADr---------rPEPRPGVESRaRQNQvceealrKQQRDg---rLLQPS--PYVGYPFFMFPDlgn-----------l 113 Nile tilapia

Q9W7C0       118 nePYMNNGSLSPpip-------------------------rtSNKVPVVQPSHAVHPLTPLITYSDEHFAPG-PHSGH-- 169 zebrafish
Q8JHX2       114 --PYLPNGSMSPl-----------------------------SNKVPVVQPSHGVHPLTPLIPYSNDHFSHG-SHSPH-- 159 chicken
XP_007473463 137 agTGPGAVSGAGq-----------------------------PLHTKPGQPSHGVPQLTPLY----EHFSSH---PTH-- 178 gray short-tail...
NP_001092656 142 pqPQPPL-----------------------------------HNKAS--QPSHGVPQLSPLYD----HFSSP--HPTP-- 176 cattle
NP_989421    114 --PYLSNGSVSAl-----------------------------SSKVPVVQPSHGVHPL---IPYNNESFSHG-SHSTH-- 156 western clawed ...
XP_003410440 122 ndPYMSNGSLSPpip-------------------------rtSNKVPVVQPSHAVHPLTPLITYSDEHFSPG-SHPSH-- 173 African savanna...
XP_003972447 114 daSYMNNGSLSPpmp-------------------------rtSNKVPVVQPSHAVHPLTPLITYSDEHFAPG-SHSGH-- 165 torafugu
XP_002596146 134 vyPH-PNGSLAAsa---------------------------tSNKVSVVHGPPHPGPLTQLMMYSNEHFAPGt--PPHig 183 Florida lancelet
XP_011603100 116 csPYLPNGALASnartylpfqwplldvaarsairdstnaahlPNNVPMVQHPHMTH-LHPLLSYSPEAFSPQrASPGF-- 192 torafugu
XP_005458373 114 csPYLANGALTAgartylpfqwplldvpgrasvrdtatpshlSSSVPMVQHPHVSH-LHPLLSYSPEAFSPPrASPGF-- 190 Nile tilapia

Q9W7C0       170 HPQ---DVNPKQaGMPRHHPGPDIPNFYPLSPGGVGQMTPPLGW 210 zebrafish
Q8JHX2       160 LPA---DISQKQ-AVHRPSQTSDIPGFYPLPPAGVGQITPSMGW 199 chicken
XP_007473463 179 VSA---DINQKQ-GVHRPLQTTDLSSFYSLSPGGVGQISHTMGW 218 gray short-tailed opossum
NP_001092656 177 APA---DISQKQ-GVHRPLQTPDLSGFYSLTSGSMGQLPHTVSW 216 cattle
NP_989421    157 LPA---DLNQKQ-GVHRPAQTADIPTFYPLPSGGVGQISPSVGW 196 western clawed frog
XP_003410440 174 IPS---DVNSKQ-GMPRHPPAPDIPTFYPLSPGGVGQITPPLGW 213 African savanna elephant
XP_003972447 166 HPH---DGSNKQ-GMPRQHPGPDMANFYSLSPGGVGQITPPLGW 205 torafugu
XP_002596146 184 VPPnsiEVDPKT-GIPRPRHPADLPPMYAIPPNQLPQLGPSYPk 226 Florida lancelet
XP_011603100 193 --------SPDT-GISRSPHTA----CYPVSPGGMAQITHPLGW 223 torafugu
XP_005458373 191 --------SPEAaGVSRSPHAS----CYPVSPGAMPQIPHPLGW 222 Nile tilapia
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