Conserved Protein Domain Family
cwf21

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pfam08312: cwf21 (this model, PSSM-Id:285507 is obsolete and has been replaced by 462421)
cwf21 domain
The cwf21 family is involved in mRNA splicing. It has been isolated as a subcomplex of the splicosome in Schizosaccharomyces pombe. The function of the cwf21 domain is to bind directly to the spliceosomal protein Prp8. Mutations in the cwf21 domain prevent Prp8 from binding. The structure of this domain has recently been solved which shows this domain to be composed of two alpha helices.
Statistics
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PSSM-Id: 285507
Aligned: 171 rows
Threshold Bit Score: 25.852
Created: 21-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6C0M9         71 EHERKRKVEVACMELQDKL----EEE-G----------------------------------------------QkGEEE 99   Yarrowia lipo...
O14161         56 EHECRRQIESKLLLYREQLleevSSQhStdaaasdsntnfgtenp------------kppkaiikdeqsqsktkSlDEAD 123  Schizosacchar...
Q5CIU6         60 EHEKLRKMELEILQFTEEQ----ESK-G----------------------------------------------L-KGAD 87   Cryptosporidi...
XP_004990934   64 DHYRRREIELKCAELEDSM----TEQ-G----------------------------------------------C-TEDE 91   Salpingoeca r...
XP_003376096  723 lHERKRKIELKCLEMQDLM----TEQ-N----------------------------------------------Y-PEEE 750  Trichinella s...
XP_002141273   53 EHQRLRQIELEVVLYLEKL----SAG-G----------------------------------------------L-TGEE 80   Cryptosporidi...
XP_002260366   61 EHSEKRKIELKVLMYEEKL----REE--------------------------------------------------GKKN 86   Plasmodium kn...
XP_001304294   49 DHESRVKIETECYLLRKKL----REQ------------------------------------------------NiPEDQ 76   Trichomonas v...
XP_011130578   53 EHEKARIIEVAVLEYEDDL----REShP----------------------------------------------EmTEQE 82   Gregarina nip...
EPY52399       57 KHERRRRIESKVLLFREELlahtESQ-QtrypdegseeretekgegegegdrnamfdgakqteesgkylshdeaQkRDEE 135  Schizosacchar...
Q6C0M9        100 IEEEVNTLRRQLTLK 114  Yarrowia lipolytica CLIB122
O14161        124 VEILVQKYREQLLKE 138  Schizosaccharomyces pombe 972h-
Q5CIU6         88 LEEAVDRKRKELAll 102  Cryptosporidium hominis
XP_004990934   92 IEAKVDEYRAQLLEK 106  Salpingoeca rosetta
XP_003376096  751 IQEKVDKYRALLRKK 765  Trichinella spiralis
XP_002141273   81 LENKVSQKRNELMKK 95   Cryptosporidium muris RN66
XP_002260366   87 IQDLVDQYRNQLYEE 101  Plasmodium knowlesi strain H
XP_001304294   77 IKTRVDKFREEQLEK 91   Trichomonas vaginalis G3
XP_011130578   83 IEQKVRQKRNSLESD 97   Gregarina niphandrodes
EPY52399      136 IELLVQEYREKLWKE 150  Schizosaccharomyces cryophilus OY26
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