Conserved Protein Domain Family
Inhibitor_I29

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pfam08246: Inhibitor_I29 (this model, PSSM-Id:285458 is obsolete and has been replaced by 462410)
Cathepsin propeptide inhibitor domain (I29)
This domain is found at the N-terminus of some C1 peptidases such as Cathepsin L where it acts as a propeptide. There are also a number of proteins that are composed solely of multiple copies of this domain such as the peptidase inhibitor salarin. This family is classified as I29 by MEROPS.
Statistics
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PSSM-Id: 285458
Aligned: 63 rows
Threshold Bit Score: 41.8616
Created: 21-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9LHU9        49 FSRWMAQYGKAYs---------------WPIEHEKRy-QIWKDNSNFIGSFRseteissgvgAFAPQTVtdsFV-GMNRF 111 Japanese rice
Q24HI2        36 HDDYVLSLARLYr--------------pHLNVEHLEf-QHFKESVRRVREHN----------KKVNATY---TLsIDSPF 87  Tetrahymena the...
Q4UDK0       129 FNDFNKHHDRKHn---------------NYRHKKASy-NNFRNNLNDINEHN----------SKPNMSY---TK-SMNHF 178 Theileria annulata
Q4UDG1       180 FKSFLKRYLKTYk---------------DLNEYKARy-LNFRVNRIFIETHN----------SNLNKLY---TM-GYTTA 229 Theileria annulata
P25781       120 FDAFVEKYKKVHr---------------SFDQRVQRf-LTFRKNYHIVKTH------------KPTEPY---SL-DLNKF 167 Theileria annulata
XP_001612131 120 FNDFNRDFKRHDn---------------SISEKIERf-ATFYRNVTRIREFN----------MNVHKTY---TM-KINQF 169 Babesia bovis T2Bo
AAT36253     167 FYLFVKEYGRKYk---------------TEEEMQQRy-LAFVENLEKIKAHN----------SRENVLY---RK-GMNQF 216 malaria parasit...
BAD11762      54 yRLYKRKYNKRDe---------------EINLEHRRf-MTYLKNVKEIEKHNer-------yERNEETY---EL-AINHL 106 Brugia malayi
XP_001418659  41 FEHYMRLHGKSKqtycsrreggaaqdvrACEATLSRaeASFRRNQRIVAQHN----------ADPSNTF---KL-RLNKF 106 Ostreococcus lu...
AHE41395      96 FTRMAKKFDRKYd---------------TVAERHTAf-LNFRRNHDIVKSHE----------HNKAATY---TK-DLNHF 145 Babesia bovis
Q9LHU9       112 GDlTPGEF 119 Japanese rice
Q24HI2        88 AFmSDEQF 95  Tetrahymena thermophila SB210
Q4UDK0       179 GDvSPKDF 186 Theileria annulata
Q4UDG1       230 ADnSDQEL 237 Theileria annulata
P25781       168 SDlSDEEF 175 Theileria annulata
XP_001612131 170 ADmTPEQF 177 Babesia bovis T2Bo
AAT36253     217 GDlSFGEF 224 malaria parasite P. vivax
BAD11762     107 ADmLPEEF 114 Brugia malayi
XP_001418659 107 ADvDSEDF 114 Ostreococcus lucimarinus CCE9901
AHE41395     146 FDkDIKAV 153 Babesia bovis
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