Conserved Protein Domain Family
zf-C3HC
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pfam07967: zf-C3HC (this model, PSSM-Id:285241 is obsolete and has been replaced by 429759)
C3HC zinc finger-like
This zinc-finger like domain is distributed throughout the eukaryotic kingdom in NIPA (Nuclear interacting partner of ALK) proteins. NIPA is implicate to perform some sort of antiapoptotic role in nucleophosmin-anaplastic lymphoma kinase (ALK) mediated signaling events. The domain is often repeated, with the second domain usually containing a large insert (approximately 90 residues) after the first three cysteine residues. The Schizosaccharomyces pombe protein containing this domain is involved in mRNA export from the nucleus.
Links
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Statistics
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PSSM-Id: 285241
Aligned: 24 rows
Threshold Bit Score: 115.153
Created: 26-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q5A9A7       102 PYDLSSLLARLKTFNSLN-Wk--SIDDSSINELKCAINGWKCvsFGvketKNHLLCT-YCNQQLILKFesndlhngnsti 177 Candida albicans
Q0CK85        87 PWDRERFLERLETFRRVDwW---SPKPTAINEVEWAKRGWVC--TD----VSRVTCAgVCGGSVVVKLpdeld------- 150 Aspergillus ter...
Q7RZE5       131 PGDRNQLVRRLATFQELTdW---TPKPDRVNEIEWAKRGWVC--QG----KERVKCT-LCNNELAVKLnrke-------- 192 Neurospora crassa
Q2GS01       131 PGDRDQLLRRLTTFQELTdW---TPKPDRVSEVEWAKRGWAC--QG----KERVKCT-LCGRELVVKVnrke-------- 192 Chaetomium glob...
O94506        40 PWSREEFLRRLLTYRSR--Wa--YVNDPQIGEINCCLNGWLC--ES----NNILVCD-VCRNKINLTAlq---------- 98  Schizosaccharom...
Q9GYR0        48 YRDMETYHKIIKTYKAPT-W-----YGCAVSPRDLADYGWAC--VK----KDCVKCI-ECEQYLSTV------------- 101 Caenorhabditis ...
Q6C0U9       109 PWSKEDFLDRVSTYTYQK-YpieTSLYPKLSPYNVARYGWKC--TS----SKMLQCV-SCGSYLAVV------------- 167 Yarrowia lipoly...
XP_001595977  58 PYDRAEFLKRLKSFSNLTdW---TPKPARVNEVEWAKRGWVC--QK----KERVRCC-FCNVEILVKL------------ 115 Sclerotinia scl...
XP_001394248  84 PWDRERFLERLETFRRVDrW---APKPSAISEVEWAKRGWVC--TD----VARVTCAgNCGGSVVVKL------------ 142 Aspergillus nig...
XP_002634353  47 iRDVEAYKKIIKTYKAPT-W---FG--CAVSPRDLADYGWEC--VK----KDCVKCV-ECEELLCTS------------- 100 Caenorhabditis ...

Q5A9A7       178 vetpfdfqyL-SG-------KTFD----------ESFQKKLVELYTKQIEnTGHGPNCLWKNFETPiEEVYHLRqyLPNT 239 Candida albicans
Q0CK85       151 ----eldgyDiEK-------VQER----------KEVRSKLVDEYAGLIV-QGHGQNCPWKNRGCD-ATIHRLP--LANH 205 Aspergillus ter...
Q7RZE5       193 ------vdgKeIP-------VLIA----------ADIAESVVDQYVELII-TSHREDCLWRKKGCD-DSLLRLP--LPNP 245 Neurospora crassa
Q2GS01       193 ------vdgKeVA-------VLIA----------SEVAESVVDAYAALIV-ESHAEDCLWRKRGCDgEEREEVP--LPAA 246 Chaetomium glob...
O94506        99 --------qVdAE-------NDSL----------NELPEKTKERLEVSLK-EEHQDNCLWRLHKFPpDIYHLSV------ 146 Schizosaccharom...
Q9GYR0       102 ---------LpNI-------CKVS----------FNVYNSSLQDIHEKMT-TAHRTTCKLRCGAPPfRIVEPTAkeVMDG 154 Caenorhabditis ...
Q6C0U9       168 -----------CG-------EEDD----------EATIKVVQDKYLGLIT-RNHSSRCLWKNKPCS-ESLGSIMgnIGRL 217 Yarrowia lipoly...
XP_001595977 116 ---------NkKEedgkekeVYIA----------ENIENALIDKYVELII-TSHDESCPWRQRGCD-DVIFKLP--LNKP 172 Sclerotinia scl...
XP_001394248 143 ---------PdEL-------DELDgfdadkvqerKEVRAKLVDEYVERLV-KGHGETCPWRNKGCD-ATIHRLP--LANP 202 Aspergillus nig...
XP_002634353 101 ---------LpNI-------CKVS----------FNVYNSRLQEIHDQLS-SAHRTTCKLRTGAPPiRFTEPTSkeIMSG 153 Caenorhabditis ...

Q5A9A7       240 nQFLIQEYCK-----NLKNLI-------DNTLILQE 263 Candida albicans
Q0CK85       206 -DTAITGLET-----RYSHVVkl----aDQLPSQDI 231 Aspergillus terreus NIH2624
Q7RZE5       246 -KLALETLRQ-----RYDELCqr----kDFLPYEFN 271 Neurospora crassa
Q2GS01       247 wEVLVVGLRNe-----------------AFIRERVA 265 Chaetomium globosum CBS 148.51
O94506       147 -SAELVQVGR-----RFNSLStrl--vsTHLPEEMT 174 Schizosaccharomyces pombe 972h-
Q9GYR0       155 iQRRLSDSKK-----IIDEDLk------ADIPSDVN 179 Caenorhabditis elegans
Q6C0U9       218 -RKDLGGKIAipegvEVTVDGqsvedffKKLLLEVD 252 Yarrowia lipolytica
XP_001595977 173 -AVTIQTLRE-----RYDELQqr----aEHLPYLSN 198 Sclerotinia sclerotiorum 1980 UF-70
XP_001394248 203 -DIAISGLEK-----RYSNLIkm----aDQLPaadv 228 Aspergillus niger CBS 513.88
XP_002634353 154 iQSRLSDSKS-----IEDDDFv------VHIPSDVN 178 Caenorhabditis briggsae
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