Conserved Protein Domain Family
Renin_r
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pfam07850: Renin_r (this model, PSSM-Id:285134 is obsolete and has been replaced by 462287)
Renin receptor-like protein
The sequences featured in this family are similar to a region of the human renin receptor that bears a putative transmembrane spanning segment. The renin receptor is involved in intracellular signal transduction by the activation of the ERK1/ERK2 pathway, and it also serves to increase the efficiency of angiotensinogen cleavage by receptor-bound renin, therefore facilitating angiotensin II generation and action on a cell surface.
Links
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Statistics
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PSSM-Id: 285134
Aligned: 32 rows
Threshold Bit Score: 106.558
Created: 13-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q17IA0       228 AFDGAVVVGLITSTEAP-----------------------------LIRSKRQAAETEDDN-----------PLNLALKY 267 yellow fever mo...
Q9XTY9       216 AYGGQAVIELLAFEAESgaaekstes------------reipnhniQKRDTKsktpt----------qlareNLQVTVPV 273 Caenorhabditis ...
XP_973593    238 VYKDKVLVSVITSDAV------------------------------HTRRARNILQEKKPEpkdt----qetKVNPAKFY 283 red flour beetle
EGT52551     216 AYGGQAVVELLTFDAETgaeenaes-------------reipthniQKRDVQYKDVLKAAr----------kSYQVAVPV 272 Caenorhabditis ...
XP_001894458 231 tYNDRVIAELITESKSEi----------------------------KKRQKRQEDSPKSPSdrim---klrkELNVYQFS 279 Brugia malayi
XP_003115056 216 sYGGQAVVELLTFDAETgsaeitsenr----------eipsdshniQKRDVSIGAFKDALNsa-------rkGFQVTVPV 278 Caenorhabditis ...
XP_004930585 246 AYDGSVLVTAVTTDi------------------------------vHTRRAIRSVSG---Nve-------lkNSVDEDGY 285 domestic silkworm
XP_002643585 217 sYGGQAVVELLTFEAESgaaentaed-----------reipsshniQKRDAAADAYKDIIQna-------rkAYMVTVPV 278 Caenorhabditis ...
EFX72790     213 tYGDRFILTAITNERL------------------------------RLREKRSTTSNAKANslre----lywKLNLSKRY 258 common water flea
CAP20583     109 AYGGHAVVELLNFKAEDssedvtssemwysefenpknpefienhkiQKREVSGIPGVREPTvyeqlrdaarkSYGVTEAV 188 Caenorhabditis ...

Q17IA0       268 DSNYPVIFNIILWFSVILVFSLLAISIAIATMDPGRDSIIYRMTStrmkkD 318 yellow fever mosquito
Q9XTY9       274 SSDYPAIFAIFLGLVVILVVALIYIVVGMASIDPEKDSIIYRMTTtrmkkD 324 Caenorhabditis elegans
XP_973593    284 SKDYPVIFNIILWFGVAMTFTLLAICIAIAQMDPGRDSIIYRMTStrlkkD 334 red flour beetle
EGT52551     273 SSDYPAIFAIFLGLVVILVVALIYIVVGMASIDPEKDSIIYRMTTtrmkkD 323 Caenorhabditis brenneri
XP_001894458 280 SGNYPATFGIFLLVSVALFLIVLFVTVGLWNMDPGKDSIIYRMVTtrmkkD 330 Brugia malayi
XP_003115056 279 SSDYPAIFAIFLGLVVILVIALIYIVVAMASIDPEKDSIIYRMTTtrmkkD 329 Caenorhabditis remanei
XP_004930585 286 SADYAAIFNIILWFGVVFTFTLIAIVYALMDMDPGRDSIIYRMTNtrmkkD 336 domestic silkworm
XP_002643585 279 STDYPAIFAIFFGLVVILVVALIYIVVGMASIDPEKDSIIYRMTTtrmkkD 329 Caenorhabditis briggsae
EFX72790     259 GSDYSSIFNILLWTSVFLIAALISTAVFICTLDPGRDSIIYRMTTqrikke 309 common water flea
CAP20583     189 SSDYPAMFAMILGLVGALVVTTIYIIVAMVSIDPEKDSIIYRMTTdsqtsg 239 Caenorhabditis briggsae
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