4K6J


Conserved Protein Domain Family
WAPL
?
pfam07814: WAPL (this model, PSSM-Id:285105 is obsolete and has been replaced by 462278)
Click on image for an interactive view with Cn3D
Wings apart-like protein regulation of heterochromatin
This family contains sequences expressed in eukaryotic organizms bearing high similarity to the WAPL conserved region of D. melanogaster wings apart-like protein. This protein is involved in the regulation of heterochromatin structure. hWAPL, the human homologue, is found to play a role in the development of cervical carcinogenesis, and is thought to have similar functions to Drosophila wapl protein. Malfunction of the hWAPL pathway is thought to activate an apoptotic pathway that consequently leads to cell death.
Links
?
Statistics
?
PSSM-Id: 285105
Aligned: 68 rows
Threshold Bit Score: 132.398
Created: 14-Jul-2015
Updated: 5-Aug-2015
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
4K6J_A         16 HVKHFNDVVEFGENQEFTDDIEYLLSGLKSTQPL-NTRCLSVISLATKCAMPSFRMHLRAHGMVAMVFKTLdDSQHHQ-- 92   human
Q9C951         77 SNSTLMEAQEFGELIENEDEVNFALDGLKKGHKV-RIRRAALSSLLSICESQYQRRSLRALGISQSIIDAIlGLCLDDip 155  thale cress
ERG86127      287 NVKEAHQCLESGEHDDYRQDIDYVLSTLLDPASTaNLKCLSVISLAKKCVSAEFRQFFRTENFFPRTIKALtDSASc--p 364  pig roundworm
XP_003374831  701 NVKQAHECHESGEAQEYNDDVVYLLGALSEENTS-NMRCLSLITLLQKCVSAAFRNFLKAHGYAKQVLYALkDAHGNDvc 779  Trichinella s...
NP_500568     215 HIKEANELRESGEYDDFKQDLVYILSSLQSSDASmKVKCLSAISLAKKCVSPDFRQFIKSENMTKSIVKALmDSPEDDl- 293  Caenorhabditi...
EJW87927      280 dVKEAHECLKSGEQDDFSDDVKYILSTLLDSSSSnNLKCLSIISLAKKCVSSEFRRFFRSNNLISRTLKAIpDSPKs--p 357  Wuchereria ba...
AAB65476      149 ftSTLLEAQEFGELMEHEDEVNFALDGLRKGHQLr-IRRASLSSLLSICASQHQRRSLRAQGISQSIIDAIlVLSLDDip 227  thale cress
XP_011410139  643 NVRQAHECLQHGENLRFRDDVIYLLDSMKTEEPL-LVRCLSTLNLAEQCLNVDFMRQMRSLGLVKKSLLLLkDAQTHP-- 719  Amphimedon qu...
CDI97216      269 KVKTSLDSQERGSVQHALDDMNYLIDGLSDANTT-DARCLSILSLANKCLTPATRDLVHAYGLLKRICANLhDAHTDY-- 345  Echinococcus ...
CBI35691      104 ataTLMETQEFGEMMEHVDEVNFALDGLRKGQPA-RIRRASLLSLLSICGTAQQRRLLRTQGMAKTIMDAViGLSFDDsp 182  wine grape

4K6J_A         93 NLSLCTAALMyilsrdrl-nmdldraS--LDLMIRLLELEQDASsakll---------------------nekdmN---- 144  human
Q9C951        156 S-NLAAATLFfvlttdgq-ddhfmesPnsIKFLVKLLRPVVSAStkvkprnigsrllsiikdvdaardaasmhdlS---- 229  thale cress
ERG86127      365 SVAISTSAVIylmardkv-cvsldatS--LRLLSQMLKMEKPKNnd---------------------------eyN---- 410  pig roundworm
XP_003374831  780 CLALATACLFyllsrdrl-clvvdecS--LGLLVNLVKPMKVDVtne--------------------------efL---- 826  Trichinella s...
NP_500568     294 -FALAASTVLylltrdfn-sikidfpS--LRLVSQLLRIEKFEQrpedkd------------------------------ 339  Caenorhabditi...
EJW87927      358 SLALCISVVVyllsrdtt-svfvdapA--LRLFSQLLKLENLNLse---------------------------ecV---- 403  Wuchereria ba...
AAB65476      228 S-NLAAATLFfaltadgq-dehfmesPkcIKFLIKLLKPVIVTStegkp---------------------rnigfKllsl 284  thale cress
XP_011410139  720 ALKVALVTLSfvmtqsnvepseldkkC--TELLVMALSVKDQFLvspageeeppplegkaateykkitdkskallK---- 793  Amphimedon qu...
CDI97216      346 SLCLAAAGLFfvisrdrd-pdlltaeS--LAVLLQLLHAPSTMTenatlatdsasmpskysigaasrqgrlnkeaN---- 418  Echinococcus ...
CBI35691      183 S-NLAAATIFfvltsdsh-ddyllesPtcIRFLLELLKPPMSNAthgkapsigikllglrkdadplrdtnktidsS---- 256  wine grape

4K6J_A        145 -----------KIKEK-----IRR-L-CET--------V------HN-----K-------Hld-----------lE---- 165  human
Q9C951        230 -----------SCD-------IID-RaQEI--------L------VN-----C-------K--------------Elrli 250  thale cress
ERG86127      411 -----------KYSKM-----VWD-VmQEW--------LdktragLE-----Q-------Evqfd-------fteA---- 442  pig roundworm
XP_003374831  827 -----------KCKEKi----WKV-L-CDWrtevessnI------RK-----V-------Limfd-------lteK---- 860  Trichinella s...
NP_500568     340 ----------------kvvnmVWEvF-NSY--------I------EKqevggQ-------Kvsfd-------mrkE---- 370  Caenorhabditi...
EJW87927      404 -----------KYSKMv----MDV-L-KEW--------L------EK-----SfanteskKvqfd-------iteK---- 436  Wuchereria ba...
AAB65476      285 lkdvdaardpvKMDDPsssdiLSR-V-QEL--------L------VN-----C-------KemrlndsyitettrP---- 332  thale cress
XP_011410139  794 -----------KCSPLl----IHA-KySDS--------S------NT-----N-------E--------------Tvdis 817  Amphimedon qu...
CDI97216      419 -----------QIRCR-----VQQ-LlEAV--------A------AH-----Q-------Q--------------Krgrk 441  Echinococcus ...
CBI35691      257 -----------STA-------IVH-KvQEV--------L------VS-----C-------K--------------Eikss 277  wine grape

4K6J_A        166 -------------------------------------------------------NITTGHLAMETLl------------ 178  human
Q9C951        251 dsy---------------------------------------------kiermrpELSTKWVALLVMekaclskisfddt 285  thale cress
ERG86127      443 -------------------------------------------------------TLSPSLLILESLv------------ 455  pig roundworm
XP_003374831  861 -------------------------------------------------------NLNTSFLALESLv------------ 873  Trichinella s...
NP_500568     371 -------------------------------------------------------SLTPSSLIIEALv------------ 383  Caenorhabditi...
EJW87927      437 -------------------------------------------------------TLSPSFLILESLv------------ 449  Wuchereria ba...
AAB65476      333 -------------------------------------------------------ELSTKWVALLAMe------------ 345  thale cress
XP_011410139  818 ---------------------------------------------------lqpsTLSLGELATECFl------------ 834  Amphimedon qu...
CDI97216      442 ssdtatkavrnsssgsnstaagmaalfvrknlgvaslfsssttvslnarhlrmnrQLTARDMILEAIl------------ 509  Echinococcus ...
CBI35691      278 sgd---------------------------------------------dngvgrpELSPKWIALLTMekacfstisledt 312  wine grape

4K6J_A        179 SLT-S---------------------Kragdwf--keelrLLG--------GL-DhivDKVKECVDHLsr---------- 215  human
Q9C951        286 SGT-V---------------------Kksggmf--keklrELG--------GL-DavfDVVMDCHTVMeswvthd----- 327  thale cress
ERG86127      456 YIC-T---------------------Rnnndqs-lknemlNLG--------VL-QwivSKVDKTVLRLlhek-------- 495  pig roundworm
XP_003374831  874 FIS-S---------------------Rsdsdaf--kqemrLNG--------GV-EiaaLRVADETKKIskak-------- 912  Trichinella s...
NP_500568     384 FIC-S---------------------Rsvnddn-lksellNLG--------IL-QfvvAKIETNVNLIadn--------- 422  Caenorhabditi...
EJW87927      450 YICaR---------------------Kh-----------rEQSlqsellnvGIlQwivSKMDKTVLRLlhe--------- 488  Wuchereria ba...
AAB65476      346 RAC-VskisfddtsgsvkktggnfkeKl-----------rELG--------GL-DavlEVVMDCHAVMerwveyd----- 399  thale cress
XP_011410139  835 SLT-S---------------------SmntsvsslkedlrTLG--------AI-DviaNRAIALTRQCtgyltsgqee-- 881  Amphimedon qu...
CDI97216      510 NLS-T---------------------Rraapwf--kagirTGG--------GL-DgvaDATIDAVDYLkdlctsdapggr 556  Echinococcus ...
CBI35691      313 SGT-V---------------------Rktggnf--kekfrEFG--------GL-DavfEVAMNCHSTLegwlkhg----- 354  wine grape

4K6J_A        216 -------------dEDEEKLVASLWGAERCLRVLESVTVHNPENQsyliay-----------kdsqlIVSSAKALQHCEE 271  human
Q9C951        328 --------tlsvedIKDDLNKQSLMLLLKCLKIMENATFLSTENQihllrlnksmgshesrlsftelMISVIKIL----- 394  thale cress
ERG86127      496 ----------vaepET----LQCLITLERCFWILETCTVYNKKNQaylish-----------rgsalIQSCGRLMAFCHE 550  pig roundworm
XP_003374831  913 ----------gdeaC-----IYPLLCLQRALRILENVTTKASQNKgylvtn-----------dslgmLDSLLTLFDFCLN 966  Trichinella s...
NP_500568     423 -----------------adDTYSILILNRCFRILESSSVFHKKNQaflish-----------rsnilISSLAKFLQVILD 474  Caenorhabditi...
EJW87927      489 -----------kisDEDMLLC--LKVLERCFRVLESATVCNEKNGaylish-----------rgsalIQSCGRLMSLLFR 544  Wuchereria ba...
AAB65476      400 --------alsvqeKKDNLHKQSLMLLLKCLKIMENATFLSTDNQnhllg-------------fkkcLGS------HDSR 452  thale cress
XP_011410139  882 -----egkeeeereGEEREVDVHFMKLFRQLKLLENILCMSKGNQsyltmf-----------dgsifISEISKFLvllgd 945  Amphimedon qu...
CDI97216      557 snffvstaknptglDEFSLDN--LKRVGHYAKMLENMTYMNPDNQthlvry-----------kervlIDRLVQCIrlcas 623  Echinococcus ...
CBI35691      355 --------spsirdAKDDANLQSLVLLLKCLKIMENAAFLSKDNQshllgmkgkgncngsrlsfiklILSIIKTL----- 421  wine grape

4K6J_A        272 LIQqynraedsicladsk-------plphqnvtnhvgkavE------------------DCMRAII-----G----VLLN 317  human
Q9C951        395 -----------------------------------------------------------------S-----G----LQLR 400  thale cress
ERG86127      551 TVD-------------------------------------Rlgdkdsa-----fvkaniTCLCRIS-----G----ILTN 579  pig roundworm
XP_003374831  967 GII-------------------------------------AkeksmpnvedknspsaqvSSLLLIVfselfR----LLCN 1005 Trichinella s...
NP_500568     475 RVHqlaee---------------------------evkkyI------------------SCLALMC-----R----LLIN 500  Caenorhabditi...
EJW87927      545 TVG-------------------------------------Rlgddine-----lkeqniTCLNRMV-----G----LLMS 573  Wuchereria ba...
AAB65476      453 MSF-------------------------------------T------------------ELTISVI-----KmlsgLHLR 472  thale cress
XP_011410139  946 yliskdl-------------------------------------------strhtcivtetLLGTL-----R----VFLN 973  Amphimedon qu...
CDI97216      624 rlprhappsvswtellwkeseektsgqqeqnqpptsstegvkpaastevefqqdqqtlltcllaiF-----R----LFVN 694  Echinococcus ...
CBI35691      422 -----------------------------------------------------------------S-----G----LSLS 427  wine grape

4K6J_A        318 LTNDNew---gsTKTGe--QDGLIGTALNCVLQVpk-yLPQEQR-FDIRVL----------------------GLGLLIN 368  human
Q9C951        401 ------------AHRNekhPHPQPHLASAVKKGFvtiiSSDTCS-----TT----------------------GFSSIKS 441  thale cress
ERG86127      580 LSHENe-----lCSTKlgqMNSFLPLCMSTFTYLaprfAPDNKR-FDLAVL----------------------MSSLLVN 631  pig roundworm
XP_003374831 1006 LSNNNeiccsklSASG-----GFIRRCVECVTFYipryLPESKR-YDMQIL----------------------FMSFVIN 1057 Trichinella s...
NP_500568     501 ISHDNe-----lCCSKlgqIEGFLPNAITTFTYLap--kfGKENsYDINVM----------------------MTSLLTN 551  Caenorhabditi...
EJW87927      574 LSYENe-----lCCTKlgqMNDFLSLCVSCFTYLvpkyVR-KEKqFDLIVllcsllvnllercnfnrrkligltvpvydl 647  Wuchereria ba...
AAB65476      473 GGFSSpntnnvnSHYSnggNHDSVLEANRKVTNEvvtiSSDTYStVgsistrngsvsqrsqsiihldfsptsmsgsqssv 552  thale cress
XP_011410139  974 ITHDNa-----lASYRvgeQEKIIDSICNFTFKLaq-sVPVIQQ-FDILVLvslllkvknnaihmliainilhCLSLLIN 1046 Amphimedon qu...
CDI97216      695 VSHSe------yASDRlggCPDLLEATLDCLFHLpd-rLPSSRR-FDLLIL----------------------VLCLLAN 744  Echinococcus ...
CBI35691      428 KSSSTisideksRNISdgiSHDSQVDCMADYKGTv------TDS-----VC----------------------VLESNGN 474  wine grape

4K6J_A        369 LVEYSARN 376  human
Q9C951        442 LSVSKRNQ 449  thale cress
ERG86127      632 LVERCNSN 639  pig roundworm
XP_003374831 1058 YIEHHQSg 1065 Trichinella spiralis
NP_500568     552 LVERCNAN 559  Caenorhabditis elegans
EJW87927      648 esrterqe 655  Wuchereria bancrofti
AAB65476      553 sgneptts 560  thale cress
XP_011410139 1047 LLEESSTN 1054 Amphimedon queenslandica
CDI97216      745 LCEHCPEN 752  Echinococcus multilocularis
CBI35691      475 LFVnysrk 482  wine grape
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap