4EAZ


Conserved Protein Domain Family
Vg_Tdu
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pfam07545: Vg_Tdu (this model, PSSM-Id:284876 is obsolete and has been replaced by 462203)
Vestigial/Tondu family
The mammalian TEF and the Drosophila scalloped genes belong to a conserved family of transcriptional factors that possesses a TEA/ATTS DNA-binding domain. Transcriptional activation by these proteins likely requires interactions with specific coactivators. In Drosophila, Scalloped (Sd) interacts with Vestigial (Vg) to form a complex, which binds DNA through the Sd TEA/ATTS domain. The Sd-Vg heterodimer is a key regulator of wing development, which directly controls several target genes and is able to induce wing outgrowth when ectopically expressed. This short conserved region is needed for interaction with Sd.
Links
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Statistics
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PSSM-Id: 284876
Aligned: 18 rows
Threshold Bit Score: 50.4043
Created: 26-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4EAZ_C        16 TEWNAGSVIFTYFEGDINSXVDEHFSRALRN 46  house mouse
Q8BGW8        78 EYINSRCVLFTYFQGDISSVVDEHFSRALSH 108 house mouse
XP_002128412 108 hHISSRCVMFNYFDGETSNEVDEHFTRALNH 138 vase tunicate
ETE64059      20 TEWGAHYMVLTYFQGDTNSMVDEHFSRALSi 50  king cobra
XP_005045733  20 TEWGSQSVVFTYFQGDINSMVDQHFSRALGN 50  collared flycatcher
XP_005325250  21 TEWNSQCVIFTYFQGDINSVVDEHFSRALSN 51  thirteen-lined ground squirrel
XP_012408758  25 tERSSRYVLFTYFQGDINSVVDEHFSRALSN 55  Tasmanian devil
XP_002932640  20 TELGSRCVVFTYYQGDINSVVDEHFSRALRT 50  western clawed frog
XP_002663398 105 EYLSARCVVFTYFRGDIGDVVDEHFSRALSQ 135 zebrafish
XP_002413900 100 QYLSANCVVFTYYSGDISSVVDEHFSRALSQ 130 black-legged tick
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