Conserved Protein Domain Family
Spp-24
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pfam07448: Spp-24 (this model, PSSM-Id:284788 is obsolete and has been replaced by 429466)
Secreted phosphoprotein 24 (Spp-24)
This family represents a conserved region approximately 140 residues long within secreted phosphoprotein 24 (Spp-24), which seems to be restricted to vertebrates. This is a non-collagenous protein found in bone that is related in sequence to the cystatin family of thiol protease inhibitors. This suggests that Spp-24 could function to modulate the thiol protease activities known to be involved in bone turnover. It is also possible that the intact form of Spp-24 found in bone could be a precursor to a biologically active peptide that coordinates an aspect of bone turnover.
Links
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Statistics
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PSSM-Id: 284788
Aligned: 13 rows
Threshold Bit Score: 182.704
Created: 13-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q711S8        67 VLGEDSLSMDIEFGIRETTCKRDSGEDPATCDFQRGYFTPSAICRSTVQISAEKVQDVWVRCRW-SSSSESNSSEE-MIF 144 pig
Q27967        67 ALDEDSLTMDLEFRIQETTCRRESEADPATCDFQRGYHVPVAVCRSTVRMSAEQVQNVWVRCHW-SSSSGSSSSEE-MFF 144 cattle
Q62740        67 VLDEDTLVMNLEFTVQETTCLRESG-DPSTCAFQRGYSVPTAACRSTVQMSKGQVKDVWAHCRW-ASTSESNSSEE-MIF 143 Norway rat
XP_003474445  67 VLDEDRVLMSLEFSIRETTCLKDSREDPSTCAFQRGYYVQTAACRSTVQMAGEQAQQVWAHCRW-ADTSESHSSEE-MIF 144 domestic guinea...
XP_012668966  67 ALDENNLVMSLEFSVRETTCRKDSGEDPSTCAFQRSYSVPSAVCRSSVQVSMEQVQSVRARCSW-ASVSDSYSSEE-MIF 144 small-eared galago
XP_003278602  69 VLDESNLVMNLEFSIRETTCRKDSGEDPATCAFQRDYYVPTAVCRSTVKVSAQQVQGVHARCSW-SSSTSESYSSEeMIF 147 northern white-...
XP_006082742  75 ILGENSSSLDIEFSVRETTCRRDSGADPATCDFQSGYYVPAASCRSTVQMSAEQVQDVWVHCRW-SSSSESDSSEE-MVF 152 little brown bat
XP_003991321  64 VLDQDSLSMDLEFGIRETTCRRESGEDPSTCDFQRGYYMPAVVCRSTVRMSAEQVRDVWVRCHW-SSSSESNSSEE-MGF 141 domestic cat
XP_005326459  66 VLDEDNVIMDLEFSIRETTCLRDSGADPSGCAFQRGHYMPAAACRSTVRMSGLQAQEAWAHCRW-PSTSESDSSEE-MIF 143 thirteen-lined ...
XP_003417987  66 IVDGDSLNMDIEFSIRETVCRRDSGEDPSTCDFQRDLYSPAAVCRSSARVSAQQVQDVWVHCRW-SSSSESSSSEE-LIF 143 African savanna...
XP_007485973  63 V-NENDLSMDIDFSIRETECRKESGSPPSACDFKRGYYVPTASCRSTVQISAEQVQSAWVRCHHaFSSSDSSSSEE--IF 139 gray short-tail...
XP_012903928  72 VLDEDSLNMDLEFGIWETTCRRDSGEDPATCDFQRGYYASPAICRSTVRMSAEQVQGVWVRCHW-SSSSESNSSEE-MFL 149 domestic ferret
XP_011221621  72 VLDQDSLNMDLEFGIRETTCRRDSGEDPDSCDFQRGYYVQAAVCRSTVRLSAEEVQDVWVRCRW-SSSSESNSSEE-MFL 149 giant panda

Q711S8       145 GDILGSSTSRNNYLRGLIPDVSRTEPLYERSl--ETMRRFPPPGNRSFPNQWPRARTNTGFE 204 pig
Q27967       145 GDILGSSTSRNSYLLGLTPDRSRGEPLYEPS---REMRRNFPLGNRRYSNPWPRARVNPGFE 203 cattle
Q62740       144 GDMARSHRRRNDYLLGFLYDEPKGEQFYDRSi--EITRRGHPPAHRRFLNLQRRARVNSGFE 203 Norway rat
XP_003474445 145 GDMGRSYNWRNDYLLGLIPEEPRSQRFYDRSp--EPMRRDFPPTNRRVPNYRHRARINGGFE 204 domestic guinea pig
XP_012668966 145 GTMLGSHIWRNNDLFGLISDESRSGQFYDRSl--EILRRAFPPGNRRYPNYRHRARIAAGLE 204 small-eared galago
XP_003278602 148 GDMLGSHKWRNNYLFGLIPDESISEQFYDRSl--EIMRRVLPPGNRRYPNHWHRARINTDFE 207 northern white-cheeked gibbon
XP_006082742 153 GGILGPSRWRNSYLVDLIPDKPRREQFYERSh--ETMRRVFPSGYRRYPNQRHRAGVNTGFE 212 little brown bat
XP_003991321 142 GDILGSSTWRNLYLPGLSPDKSRSER-SERSl--ESLRRIFPPGNRGYPYKGHRTRTNAGFE 200 domestic cat
XP_005326459 144 GDMMRSYRWRNNYLLGLIPEEPRNEQYYDPSl---DLRRSFPPGSGRSPRYQHRPRANTGFE 202 thirteen-lined ground squirrel
XP_003417987 144 EDMLRSYRWRNNYPQGLIPDGPRNEQFHERSp--ETTRRFSPPGNRRQPAPQYRERTYADFE 203 African savanna elephant
XP_007485973 140 AGRWGSPTWRRYYMGGVDSNEARRERLSPRStglRDVAR-LPARSRRRQDDRNRyglse--- 197 gray short-tailed opossum
XP_012903928 150 GDILGSSKWRNNYLLGLISDRSRSE-FYERSl--ESPRGIFPPGNRGYRNRWHRlqe----- 203 domestic ferret
XP_011221621 150 GDIFESFKWRNNYLRG-------------------SLRGIFPPGNRGYPNTWHRlqe----- 187 giant panda
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