Conserved Protein Domain Family
DGCR6
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pfam07324: DGCR6 (this model, PSSM-Id:284689 is obsolete and has been replaced by 462145)
DiGeorge syndrome critical region 6 (DGCR6) protein
This family contains DiGeorge syndrome critical region 6 (DGCR6) proteins (approximately 200 residues long) of a number of vertebrates. DGCR6 is a candidate for involvement in the DiGeorge syndrome pathology by playing a role in neural crest cell migration into the third and fourth pharyngeal pouches, the structures from which derive the organs affected in DiGeorge syndrome. Also found in this family is the Drosophila melanogaster gonadal protein gdl.
Links
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Statistics
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PSSM-Id: 284689
Aligned: 9 rows
Threshold Bit Score: 232.799
Created: 27-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q17NK5       270 DS--QAESQEsttdlalveepyqsqefL--QRKLYFLLEQLKKMHATLPEQFQLRISYELLAGLANSLLNDTIFEIVKGL 345 yellow fever mo...
O73770         9 YEvaAAELSR-----------------Q--QERHYRLLSELQELVKALPSSCQQRLSYTTLSDLALALLDGTVFEIVQGL 69  chicken
O35347         9 DE--AADRAR-----------------Q--QERHYQLLSALQSLVKELPSSFQQRLSYTTLSDLALALLDGTVFEIVQGL 67  house mouse
XP_003974503   5 pgtvgGDSTK-----------------Q--QERHYYLLSELQALVKDLPSSFQQRLSYNTLSDLALALIDGTVYEIVQGL 65  torafugu
XP_002932120   9 EE--PRDITQ-----------------Q--QERHYYLLSELQSLVKDLPSSCQQRMSHTILSDLALALIDGTVFEIVQGL 67  western clawed ...
XP_001353153   6 vsnegptngsepvavaedpfqqpspefL--QRKIYFLVDQLRTMHAELPENLQTRISYDLLTELANCVLNDSIFVIVKAL 83  Drosophila pseu...
XP_002065323  15 ET--AADSES-----------------QclQRKIYFLVDNLRSYHAELPVTLQTRISYELLTELAHCVLNEGIFEIVKAL 75  Drosophila will...
XP_005990340  12 EE--PADTTK-----------------Q--QERHYYLLSELQNLIKSLPSSCQQRLSYTMLSDLALALIDGTVFEIVQGL 70  coelacanth
XP_011416515  36 EE--IVRREN-----------------Q--QKRHYFYQNELQNMARELPGKYQQRLPYDLLSSLANSLLDGTVFEIVRSL 94  Pacific oyster

Q17NK5       346 MEIQHVTEKHLMQVREKVENDHQLEVKQWESKIQDPEE----LEHIIALMKIKHSKNM-----------KETDMKLVLHL 410 yellow fever mo...
O73770        70 LEIQHLTEKNLYSQRLKLHSEHRGLKQELFHRHKEAQQc--cRPHNLPLLRAAQQREMeaveqrireeqRMMDEKIVLEL 147 chicken
O35347        68 LEIQHLTEKSLYNQRLRLQNEHRVLRQTLRQKHLEAQQs--cRPHNLPVLQAAQQRELeamehrireeqQAMDRKIVLEL 145 house mouse
XP_003974503  66 LDIQHLTEKNLYNQRQKLHCEHQALKQELTRKHKDALQt--cKSHNLALLKTNQQAELealeirvkeeqRMMDKKIVAEM 143 torafugu
XP_002932120  68 LEIQHLTEKNLYNQRLKLHAEHRGLKQDLLRKHREAQQs--cKAHNFQVLKATQQRELesleqrikeeqRMMDEKIVLEL 145 western clawed ...
XP_001353153  84 MELQHETERHLIKMRMQVENEYEIEVSDWRAKIKDPEE----LLHILGLMKLKHSKKL-----------VESDKKIIEIL 148 Drosophila pseu...
XP_002065323  76 LELQHATEKHLLQMRLQVENEYEIEVTEWCSKIKDPKE----LAHLLDLLKAKHVNKL-----------KDADKKIIEVL 140 Drosophila will...
XP_005990340  71 LEIQHLTEKNLYNQRLKLHSEHRA-------------------------FEVKILYETaleqr-ikdeqRMMDEKIVLEL 124 coelacanth
XP_011416515  95 QEVQQLEERHLHTQRVKLVNDHKAQRHELQKRHKELLQgcqtKPHNLPIVEVQIEREKetmekrceeevKKKDMKIIMEL 174 Pacific oyster

Q17NK5       411 DQKVKDQQSTLEKAGVPGFYVSDNPMEIKIQMYLLDFILRLSRLKFEPNK 460 yellow fever mosquito
O73770       148 DQKVIDQQSTLEKAGVSGFYITTNPQELTLQMNLLELIRKLQQKESESEK 197 chicken
O35347       146 DRKVADQQSTLEKAGVAGFYVTTNPQELTLQMNLLELIRKLQQRSCQVGK 195 house mouse
XP_003974503 144 DQKVIDQQNTLEKAGVPGFYITTNPQELTMQMNLLELILKLQQKESQSGi 193 torafugu
XP_002932120 146 DQKVIDQQTTLEKAGVSGFYITKNPQELMLQMNILELIQKLQQKESLSNK 195 western clawed frog
XP_001353153 149 DQKVNDQQSTLQKAGVPGFYVTENPKEIKIQMFLLDFILRLSRLNYEPNK 198 Drosophila pseudoobscura pseudoobscura
XP_002065323 141 DQKVNDQQSTLHMAGVPGFYATQNAKEIKIQMFLLDFILRLSRLKYKPNK 190 Drosophila willistoni
XP_005990340 125 DQKVIDQQSTLEKAGVPGFYVTTNFQELTLQMNLLELILKLQQKETHLGg 174 coelacanth
XP_011416515 175 DQKVMDQQVMLEKAGVPGFYVTNKSIDVRIQMYLLDFITRLGHmqpp--- 221 Pacific oyster
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