Conserved Protein Domain Family
FAST_1
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pfam06743: FAST_1 (this model, PSSM-Id:284217 is obsolete and has been replaced by 461999)
FAST kinase-like protein, subdomain 1
This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2.
Links
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Statistics
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PSSM-Id: 284217
Aligned: 137 rows
Threshold Bit Score: 45.5209
Created: 12-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q28DE0       560 YATLLPFVVLNYDPPNgeAFFDACIQHFLPH--LNSFD--PHLVVLLAYSLALAEYFPEELIKAVFNVDFLGR 628 western clawed frog
ETE57442     477 AKLLWSFGTLNYQPPNreEFYASLLEQLESR--LFEYNkfPEHLITSLIGLAFVECFPYDLLDYALSPEFIEl 547 king cobra
XP_002609966 433 AKFLWTFAQLNYRPANvdLFLDTMVKELCAR--SNEFQtfPEHLVYSVVALAYMERFPYDLINTIFSPDTLQQ 503 Florida lancelet
XP_011607517 462 CKLLWAFGTLGFLPAQcpSFYSSLTESLRQR--KAEFQqyPEHLLTGLLGLAFVSQFPQDLIELALSPEFVKl 532 torafugu
XP_006626590 376 AKLLWAFCSLGYQPSNtpAFLCSLTQQLRAR--APEFEryPEHLLTGLLALAFVGRFPRDLLGLALSPRLVRR 446 spotted gar
XP_698448    442 AKMLWAYGSLGFLPSQcpDLYPSLTALLRER--QSEFQrfPEHLLTGLLGLAFAGLFPEDLLSLALSEEFVDR 512 zebrafish
EFA02702     604 ARVVYLCYSLGYQPKKssEFFETAINVIIRD--QERMT--GLSLIYTAVALCFFNQLPNSLIKSIFNEEFMDK 672 red flour beetle
XP_001962327 651 eKVLTCSYNLGYTPTs-lEVLEHASEVLIRD--FDQMS--GLAIVQACLALCFYKSIPEELINRIFCVKFIQR 718 Drosophila ananassae
XP_011678653 450 yltLWSFCRLNYTPDEfnSFLEAAVARIGEKeeWTDNS--AFLFVKTLVPLSFVGKYPVELIHRIFSPVYLKK 520 purple sea urchin
XP_011666304 458 TKILWSFGTLQYLPDk-pYFLPTVLEQLIEL--QGEMEeyPLNLVSSLLSLAYLQRYPWELINRLFSPDFLHT 527 purple sea urchin
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