Conserved Protein Domain Family
Vert_HS_TF
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pfam06546: Vert_HS_TF (this model, PSSM-Id:284062 is obsolete and has been replaced by 461944)
Vertebrate heat shock transcription factor
This family represents the C-terminal region of vertebrate heat shock transcription factors. Heat shock transcription factors regulate the expression of heat shock proteins - a set of proteins that protect the cell from damage caused by stress and aid the cell's recovery after the removal of stress. This C-terminal region is found with the N-terminal pfam00447, and may contain a three-stranded coiled-coil trimerization domain and a CE2 regulatory region, the latter of which is involved in sustained heat shock response.
Links
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Statistics
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PSSM-Id: 284062
Aligned: 14 rows
Threshold Bit Score: 242.81
Created: 25-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q00613       247 YSSSSLYAPDAVASSGPIISDIT------E-------------LAPASPMASPGGSIDERpl-----sSSPLVRVKEE-- 300 human
XP_005022594 225 YSGSNLYSPDSSANSGPIISDVT------E-------------LAQSSPSASPSGSLDER--------SSPVVRIKEE-- 275 mallard
XP_003763259 209 YSGSNLYSSDSAANSGPIISDVT------E-------------LAQSSPSASPSGSVDER--------ISPMIRIKEE-- 259 Tasmanian devil
EFB17014     247 ysssslyspDAVASSGPIISDIT------E-------------LAPSSPLASPGGSVDERpl-----sGSPLVRVKEE-- 300 giant panda
XP_006014660 241 YTGTKLYSSDSAENLGPIISDVT------D-------------LAQSSPCVSPSASTREErxaavpteSSPVIRIKEE-- 299 coelacanth
XP_006635898 250 YTGANLYSADSPVNSGPIISDVT------D-------------VAQSSPSDTATEWSEER--------TSPLVHIKEE-- 300 spotted gar
XP_005159390 244 FTGTGVFSSESPVKTGPIISDIT------E-------------LAQSSPVAT-DEWIEDR--------TSPLVHIKEE-- 293 zebrafish
XP_002942927 415 FADSSLYSPDSSA--GPIISDVT------E-------------LAESSPSPSPCLSLEASp--------SPVILIKEE-- 463 western clawed ...
XP_012428115 306 lNRNEGLKQREQISDDIVIYDVT------EdvgeeehpmadeeNTPVTPETSEDTTSDSSncs--csyHSPDIVIVEDdn 377 zebra finch
XP_003769453 230 HSRTEGLKPREQISEDIIIYDVTddnideE-------------NAPVTPETNEDATSDTSnc-----sQYPDIVIVEDdn 291 Tasmanian devil

Q00613       301 --------------------PPSPPQSPRVEEASPGRP-Ss------VDTLLSPTALIDSILRESEPA----------PA 343 human
XP_005022594 276 --------------------PPSPSRSPKIEEASPGNPpA-------VETPLSPSTFIDSILQENEPS----------TT 318 mallard
XP_003763259 260 --------------------PPSPPRSPQIEEISPSHPpSv------VETPLSPCTFIDSILQESEPS----------TA 303 Tasmanian devil
EFB17014     301 --------------------PPSPPRSPRVEEASPGHPsSv------VEIPLSPTALIDSILRESEPA----------PT 344 giant panda
XP_006014660 300 --------------------PPSPAHSPQIEEVS--VIdTg------TESCLSPSTFIDSILQENETSgssnastsidPS 351 coelacanth
XP_006635898 301 --------------------PDSPVHSPQVEEVSPATVa--------TDTPLSPSTFIDSILRDSEAS----------TT 342 spotted gar
XP_005159390 294 --------------------PSSPAHSPEVEEVCPVEVeVgagsdlpVDTPLSPTTFINSILQESEPV----------SA 343 zebrafish
XP_002942927 464 --------------------PLTPSHSPEQSPAPPRv----------EDTPVSPSTFIDSILQESEAS----------VC 503 western clawed ...
XP_012428115 378 edeyapviq-gdkntesvavPGNDPASHVSDSTSPLMSsAvqvnnqsTLTAEDPVSVMDSILNENGVI----------SQ 446 zebra finch
XP_003769453 292 eddyatviqggdkssdptsvPITDHESSVIESGSSLMSnAvqvnnssALTSEDPVSMMDSILNE---------------- 355 Tasmanian devil

Q00613       344 svtaltdarghtdtegrppsP--------PPT---------------ST-----------------PEKCLSVACLDK-- 381 human
XP_005022594 319 --------------------Taaag-nstTQP---------------QP-----------------QEKCLSVACLDK-- 343 mallard
XP_003763259 304 --------------------A--------SVSgtvggaisppppgplQT-----------------PEKCRSVACLDK-- 336 Tasmanian devil
EFB17014     345 --------------------T--------LAT---------------PLtdaggrrpspspppasaPEKCLSVACLDK-- 379 giant panda
XP_006014660 352 --------------------T--------AQS---------------QP-----------------EERCLSVACLDR-- 369 coelacanth
XP_006635898 343 ------------------------------QP---------------PS-----------------EEKCLSVACLDK-- 358 spotted gar
XP_005159390 344 --------------------L--------TPP---------------PS-----------------EQKCLSVACLDK-- 361 zebrafish
XP_002942927 504 --------------------PggnknegvSQS---------------NP-----------------PEPCLSVACLDNis 531 western clawed ...
XP_012428115 447 -----------------------------------------------------------------------NINLLGK-- 453 zebra finch
XP_003769453 356 -----------------------------------------------------------------------NINLLGK-- 362 Tasmanian devil

Q00613       382 -----------------------------------NELSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPD 426 human
XP_005022594 344 -----------------------------------NELNDHLDTIDSNLDNLQTMLTTHGFSVDTSALLDLFSPSMTVTD 388 mallard
XP_003763259 337 -----------------------------------NELSEHLDTMDSNLDNLQTMLTTHGFSVDTSALLDLFSPSMSVTD 381 Tasmanian devil
EFB17014     380 -----------------------------------TELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTVPD 424 giant panda
XP_006014660 370 -----------------------------------NDLCDHLDTIDSNLDNLQTMLSAQSFSMDTSTLFDLFNPSLPTSD 414 coelacanth
XP_006635898 359 -----------------------------------NELNDHVDNIDTSLENLQTILNGQSINFDSSPLFDFFNSSMSTPD 403 spotted gar
XP_005159390 362 -----------------------------------TELHDHLESIDSGLENLQQILNAQSINFDSSPLFDIFSSAASDVD 406 zebrafish
XP_002942927 532 ssrqmsevsrlfptstcssssslqgrtdpgldisvTELNDHVDSIDFSLDNLQNLLNGQSFSVDTSALLDLFSPSLGIPD 611 western clawed ...
XP_012428115 454 -----------------------------------VELLDYLDSIDCSLEDFQAMLSGRQFSIDPDLLVDLFTTSVQMNP 498 zebra finch
XP_003769453 363 -----------------------------------VELLDYLDSIDCSLEDFQAMLSGRQFSIDPDLLVDLFTSSVQMNP 407 Tasmanian devil

Q00613       427 MSLPDLDSSLASIQELLSPQEPP-RPP---EAE--NSSPDSGKQLVHYTAQPLF-LLD--------PGSVDTG---SN-- 486 human
XP_005022594 389 MNLPDLDSSLASIQDLLSSQEQQ-KPT---ETE--ASTADTGKQLVHYTAQPLF-LVD--------SSAVDVG---SG-- 448 mallard
XP_003763259 382 MSLPDLDSSLASIQDLLSSQEQP-KPL---ETE--TGGADSGKQLVHYTAQPLF-LVD--------SSTLDTT---GN-- 441 Tasmanian devil
EFB17014     425 MSLPDLDSSLASVRRQGGEREPRlSPA---SAL--TQPPPPGKQLVHYTAQPLF-LVD--------PGSVDMG---SS-- 485 giant panda
XP_006014660 415 MGLPDLDTSLDTIQDLLSSQEQ--KPT---DTD--SNTADTGKQLVHYSAQPLF-LLD--------SGSGDMG---SG-- 473 coelacanth
XP_006635898 404 FNLPDLDTSLASIQDLLTQD--Q-KAT---ETT--EPSTDAGKQLVQYTAQPVL-LVD--------PSNAEIT---SG-- 461 spotted gar
XP_005159390 407 LD------SLASIQDLLSPD--P-VKE---TES--GVDTDSGKQLVQYTSQPIV-LPD--------PLSTDSS---ST-- 458 zebrafish
XP_002942927 612 LPLPDPDSSLASIQELLSSQDQK-ASE---TVE--SRTPDAGKQIVHYTAQPLI-LMD--------SS--------GS-- 666 western clawed ...
XP_012428115 499 TDHDHITNTKVETKGKETNKNNA-DPAasqEMQ--GTKPRSDKQLIHYTAFPLLaFLDg------nPGSA-VE---SGvf 565 zebra finch
XP_003769453 408 T--DYISNTKLENKGSETNKNNEvQPT---SEDgkNSKPKSDKQLIQYTAFPLLaFLDgspsstveNGSATSEaasSL-- 480 Tasmanian devil

Q00613       487 --DLPVLFEL-GEGSYFS-EGDGFAE-----DPTISLLTGSEPPKAKDPTVS 529 human
XP_005022594 449 --DLPIFFEL-GEGPYFT-DGDEYAE-----DPTISLLSGTEQAKPKDPAVS 491 mallard
XP_003763259 442 --DLPIFFEL-GEGPYFS-EGDDYSD-----DPTISLLSGSEPTKAKDPAVS 484 Tasmanian devil
EFB17014     486 --DLPVLFEL-GEGSYFS-EGDDYTD-----DPTISLLTGSEPSKAKDPTVS 528 giant panda
XP_006014660 474 --DLPILFEL-GDAPYFA-EGDE-SE-----DPTIALLSSTDESKPKDPAIS 515 coelacanth
XP_006635898 462 --ELPILFAL-END--FG-TGEE-GE-----DPTISLLSNDYQQKPEDPTSS 501 spotted gar
XP_005159390 459 --DLPMLLEL-QDDSYFS---SEPTE-----DPTIALL--NFQPVPEDPKLS 497 zebrafish
XP_002942927 667 --DLPILLELeGDEPYVAeEGDDYSE-----DPTLSLLCWDPQSKPAGSSIS 711 western clawed frog
XP_012428115 566 taETPSTVEK-S-----V-EGDELLEssldpQPTQSKLVRLEPLT--EAEAS 608 zebra finch
XP_003769453 481 --DKPL-------------GVDELLDssldpEPTQSKLVRLEPLT--EAEAS 515 Tasmanian devil
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