Conserved Protein Domain Family
zf-FCS
?
pfam06467: zf-FCS (this model, PSSM-Id:283998 is obsolete and has been replaced by 428958)
MYM-type Zinc finger with FCS sequence motif
MYM-type zinc fingers were identified in MYM family proteins. Human protein ZMYM3 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. ZMYM2 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.
Links
?
Statistics
?
PSSM-Id: 283998
Aligned: 41 rows
Threshold Bit Score: 35.4045
Created: 25-Jun-2015
Updated: 5-Aug-2015
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Q65174         53 WVTHSSFKCWTCHLYFKTVPKfvptymRENErgeiemGVLGNFCSFSCAASY 104  African swine fever virus BA71V
Q9VHA0         55 GRPAKRATCTWCGEGKLPLQYv-----LPTQ------TGKKEFCSETCIAEF 95   fruit fly
Q172L2         61 SSSTGGSSCIWCGENKNPLKYv-----LPTQ------NGKKEFCSETCILEF 101  yellow fever mosquito
Q9UBW7        417 KGALNKSRCTICGKLTEIRHE------VSFK------NMTHKLCSDHCFNRY 456  human
A6QPH9        331 KRVLNKSRCTICNKLTEIRHE------VSVN------NVTHKLCSNQCFNKY 370  cattle
Q5RDJ2        760 DWYYKAARCDCCKSQGTLKEr------VQWR------GEMKHFCDQHCLLRF 799  Sumatran orangutan
Q9EN01         36 DNIDLTNNCIYCNDVIKDKIIi-----DTNN------IKVGYFCTITCKHIY 76   Amsacta moorei entomopoxvirus 'L'
XP_004310894  719 LWYCKAARCHACKRQGKLLET------IHWR------GQIRHFCNQQCLLRF 758  bottlenosed dolphin
XP_007122145  401 GDPADATRCSICQKTGEVLHE------VSNG------SVVHRLCSDSCFSKF 440  sperm whale
XP_007634314   29 GLTGPPRPCSFCRRSLSDPCYy-----NKVD------RTVYQFCSPSCWTKF 69   Chinese hamster
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap