3ALZ


Conserved Protein Domain Family
SLAM
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pfam06214: SLAM (this model, PSSM-Id:283796 is obsolete and has been replaced by 461853)
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Signaling lymphocytic activation molecule (SLAM) protein
This family consists of several mammalian signaling lymphocytic activation molecule (SLAM) proteins. Optimal T cell activation and expansion require engagement of the TCR plus co-stimulatory signals delivered through accessory molecules. SLAM, a 70-kDa co-stimulatory molecule belonging to the Ig superfamily, is defined as a human cell surface molecule that mediates CD28-independent proliferation of human T cells and IFN-gamma production by human Th1 and Th2 clones. SLAM has also been recognized as a receptor for measles virus.
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Statistics
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PSSM-Id: 283796
Aligned: 14 rows
Threshold Bit Score: 204.194
Created: 27-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3ALZ_B         1 MDPKG-LFSLTFVLFLSLAFEPSYGTGGRMMNCPK-IVQQLGSDVLLPLTHERINTSMNKSIHIVVTMAKSLENSVENKI 78  cotton-top tamarin
Q1RML5         1 MDPKG-LLSSNVLLLFSLIIELSCRTGEGLTSSTKtILGQLGSSVLLPLASEEISRSMNKSIHILVTMAESPKDTVKKKI 79  cattle
XP_005245513   1 MDPKG-LLSLTFVLFLSLAFGASYGTGGRMMNCPK-ILRQLGSKVLLPLTYERINKSMNKSIHIVVTMAKSLENSVENKI 78  human
XP_012664021   1 MDLKR-LHSLTLLLFLSLAFEQSYGIGGGMMNCPK-TLHQLGRKVLLPLTHEGINKSMDKSIHIVVTVATSPENSVKKKI 78  small-eared galago
XP_005339418   1 MDTKG-LLSLSLLLILTLAFELSYATGGGVMNCPK-ILWPLGSDVVLPLTSERINKSMNKSIHILVTMAESPESSIKKKI 78  thirteen-lined ...
NP_001230749   1 MDPKRrLFSLNVLLLLSLAFELSCTTGEGSMNCPK-VLGRLGSSVLLPLTSEGIRKSMNKSIHILVSMAESPVHNIKKKI 79  pig
XP_004775935   1 MDPKR-LLSLNFLLFLSLAFELSCGTGESLLNCPE-IPGQLGNSVLLPLASGGISKSMNKSVHVLVTRAESPGNSVKKKI 78  domestic ferret
XP_006096973   1 MDPKG-LLSLNVLLFLSLACDRSCGTGGSLVSCPT-IFGQLGSSVLLPLISEGISKSMNKSIHMFITWAKSPGNRSSKKI 78  little brown bat
NP_001265755   1 MDLKG-LLSLNFLLFLSLAFELSCGTGESLMTCQE-VTEQLGRNLLLPLASEGISKSMNKSIHILVTKSESPQKNVKTKI 78  domestic cat
XP_003415237   1 MDSKG-LLSLNLLLLLSLASELSCGTGGHSMDCPK-IIQRLGSKLMLPLTYKGINKSMSESIRIVVTMETSLGSIFKKKI 78  African savanna...

3ALZ_B        79 VSLDPSEAGPPRYLKDRYRFYLENLSLAIRESTKKDEGWYFMTLEKN 125 cotton-top tamarin
Q1RML5        80 VSLDLRKGDSPR-LNDGYEFHLENLSLRILKSRKEDEGWYFISLEEN 125 cattle
XP_005245513  79 VSLDPSEAGPPRYLGDRYKFYLENLTLGIRESRKEDEGWYLMTLEKN 125 human
XP_012664021  79 VSLDPSEGGPPHYLKDRYKFHLENLSLDILESRKEDEGWYFMTLEKN 125 small-eared galago
XP_005339418  79 VSLDPSEKGSPSYLEDGYQFHLENLSLVILGSKNDSEGWYFMSLEEN 125 thirteen-lined ground squirrel
NP_001230749  80 VSLDLPEGSSPRYLEDGYAFHLENMSLSILESKKEDEGWYFLSLEEN 126 pig
XP_004775935  79 ASLDLPEGGSPRYLENGYTFHLENLSLGILESRKENEGWYFMTLEEN 125 domestic ferret
XP_006096973  79 VSLDLPEEGSSRYLEDGYKFYQENLNLEILESKKEHEGWYTMTLEKt 125 little brown bat
NP_001265755  79 VSLSLPERASPRFLENGYKFHPENLKLEILQSKKENEGWYFTTLEEN 125 domestic cat
XP_003415237  79 VSLDPSERSSPPNLEDRYKFHLESLSLEILKSRKEDEGWYSMTMEQN 125 African savanna elephant
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