Conserved Protein Domain Family
GDE_C
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pfam06202: GDE_C (this model, PSSM-Id:283786 is obsolete and has been replaced by 428822)
Amylo-alpha-1,6-glucosidase
This family includes human glycogen branching enzyme AGL. This enzyme contains a number of distinct catalytic activities. It has been shown for the yeast homolog GDB1 that mutations in this region disrupt the enzymes Amylo-alpha-1,6-glucosidase (EC:3.2.1.33).
Links
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Statistics
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PSSM-Id: 283786
Aligned: 12 rows
Threshold Bit Score: 491.086
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q06625 1045 MTSIQMVSRMKSTSil-------------------pGENVPSMAAGLPHFSvnymRcWGRDVFISLRGMLLTTGRFDEAK 1105 Saccharomyces cerev...
Q9RXW4  327 VAADAYLVRRGQETkrgsgk----------ggaskgTPRGLSVIAGYPWFA----D-WGRDAMIALSGLTLVTGRFEDAR 391  Deinococcus radiodu...
Q8KPV1  289 LAADQFIVDRPLPN----------------------HPQGKSILAGYHWFA----D-WGRDTMISLPGLTLATGWPDLAR 341  Synechococcus elong...
Q8YNC7  310 KAGDQFIVYRD-------------------------SIAGPTVIAGYHWFN----D-WGRDTLIALPGLALVPQRFELAK 359  Nostoc sp. PCC 7120
Q7MGB4  392 avmwarlssRTFVS----------------------HEFGVGIWAGLPWFK----DcWGRDTFIALSGTSLINGLFDEAK 445  Vibrio vulnificus Y...
P35573 1042 LGSVQLCGVGKFPSlpilspalmdvpyrlneitkekEQCCVSLAAGLPHFSsgifRcWGRDTFIALRGILLITGRYVEAR 1121 human
O62334  998 ISTLSFLGYIPGAGlapipt-----------slqieDQYPSSLAAGLSHFAvgiwRnWGRDTFIALPGCLLSTGRFQEAR 1066 Caenorhabditis elegans
Q9W2H8 1147 lSTLQFLSVCKSANlpgfspa---------lsppkpPKQCVTLSAGLPHFStgymRcWGRDTFIALRGSMFLTGRYNEAR 1217 fruit fly
Q9HL89  252 YNSLSFLMRH-------------------------------DMIAGFHWFG----P-WGRDTFISMPGVLLVSGRYNEAR 295  Thermoplasma acidop...
Q973T3  246 ISSTDFVVK---------------------------GKTGWSIIAGYHWFD----E-WGRDTFISMEGLLLLNRLFNQAK 293  Sulfurisphaera toko...
Q8TMM8  282 RATDSFVVKNH-------------------------ATGENTVIAGYHWYS----D-WGRDSMISLPGLLLIPYRFEEAR 331  Methanosarcina acet...
Q8XHY8  280 IAGDQFIVNRE-------------------------SIKGKTILAGYPWFL----D-WGRDAMIAINGLTLSTGRLEDAK 329  Clostridium perfrin...

Q06625 1106 AHILAFAKTLK-------HGLIPNLLDA-GRNPR----YNARDAAWFFLQAVQDYVYIVPDgEKILqeqvTRRFPlddty 1173 Saccharomyces cerev...
Q9RXW4  392 ELLLTFLGQRR-------RGLIPNHFDEsGQGAG----YNTVARPLWLAVALERYARTTGD-ALFV----RQALP----- 450  Deinococcus radiodu...
Q8KPV1  342 EILLTFAQFVS-------QGMLPNRFPD-DGNPLtdadYNTVDATLWYVEAVRQYLDCSGD-KTLL----AEIFP----- 403  Synechococcus elong...
Q8YNC7  360 GLLQTFGRYCR-------HGLIPNAFPDiDSEPY----YNSIDAALWWIETLGLYLEATQD-WQFL----AEQFP----- 418  Nostoc sp. PCC 7120
Q7MGB4  446 AIISNFASMQKsnlddvnHGRIPNRVTS-KTNII----YNTTDGTPWMIREIMEYLHYSGD-MAFA----QQIYP----- 510  Vibrio vulnificus Y...
P35573 1122 NIILAFAGTLR-------HGLIPNLLGE-GIYAR----YNCRDAVWWWLQCIQDYCKMVPNgLDILkcpvSRMYPtddsa 1189 human
O62334 1067 QIILSFAGAIR-------HGLIPNLLAE-GIGAR----YNCRDATWFWLVSIVKYVESAPNgVGILedpvRRIYPnddsv 1134 Caenorhabditis elegans
Q9W2H8 1218 FIIIGFGQTLR-------HGLIPNLLDS-GSKPR----FNCRDAIWWWMYCIKQYVEDAPKgAEILkdkvSRIFPyddad 1285 fruit fly
Q9HL89  296 RVLEHYAERIQ-------DGMIPNTQ---DVEAL----RFSADTSLWFIYAVQKYLEYAGD-DDFA----RQMLV----- 351  Thermoplasma acidop...
Q973T3  294 DIILRYLDYES-------KGLLPNHITA-NGEPI----YVGVDVSLWAINSIYSYYLYSKD-KEFI----RKIYP----- 351  Sulfurisphaera toko...
Q8TMM8  332 SALNNFARYCR-------RGLIPNTFPAfGGDPI----YNTVDASLWFIHALDRYFAYTQD-FLFL----SDVWD----- 390  Methanosarcina acet...
Q8XHY8  330 DIIRSFSLYEK-------DGLIPNMFPGkGQEPL----YNTVDASLWFINAVYNYLLYANS-YEALefveKEVYK----- 392  Clostridium perfrin...

Q06625 1174 ipvddprafsysstleeIIYEILSRHAKGIKFreanagpnldrvmtdkgfnvEIHVDWSTGLIHGGSQYNCGTWMDkmge 1253 Saccharomyces cerev...
Q9RXW4  451 -----------------MLRELLGSLVQGTDY--------------------GIGMDPADALLRAGEPGVQLTWMD---- 489  Deinococcus radiodu...
Q8KPV1  404 -----------------VLQNIIGWHQRGTRF--------------------NIHLDPQDGLLTAGAAGVQLTWMD---- 442  Synechococcus elong...
Q8YNC7  419 -----------------TVQQIYKAYFGGTRY--------------------NIQLDATDGLIGWDARNVALTWMD---- 457  Nostoc sp. PCC 7120
Q7MGB4  511 ---------------------VVQRFIQGVE---------------------KHYLD-EDGLMSHRD---PDTWMD---- 540  Vibrio vulnificus Y...
P35573 1190 plpa----gtldqplfeVIQEAMQKHMQGIQFrernagpqidrnmkdegfniTAGVDEETGFVYGGNRFNCGTWMDkmge 1265 human
O62334 1135 ygeg-----evqqmlieTIYEALDKHFAGIDYrersagpqideqmrdegfqvTAGVSRTTGFIYGGNRWNCGTWMDkmgs 1209 Caenorhabditis elegans
Q9W2H8 1286 ahap----gafdqllfdVMQEALQVHFQGLQYrernagyeidahmvdqgfnnQIGIHPETGFVFGGNNFNCGTWMDkmgs 1361 fruit fly
Q9HL89  352 -----------------PIKSIITAYIKGNS---------------------MFHLD-DDLVTLTGS---PLTWMD---- 385  Thermoplasma acidop...
Q973T3  352 -----------------KLQDIVENYAKGNG---------------------VVYIK-EGLLFHRGA---PRTWMD---- 385  Sulfurisphaera toko...
Q8TMM8  391 -----------------TVSSIIDNYCAGTDF--------------------AIGMD-SDYLIWQGP---QLTWMD---- 425  Methanosarcina acet...
Q8XHY8  393 -----------------TIKNIIKAYKEGTKF--------------------SIKMDEEDSLINAGSGLDQVTWMD---- 431  Clostridium perfrin...

Q06625 1254 sekAGSVGI-PGTPRDGAAIEINGLLKSAL----RFVIELKNkGLFKfsdve----tqdggRIDFTEWNQLLQDNFEKRY 1324 Saccharomyces cerev...
Q9RXW4  490 ---VKIHDW-VVTPRHGKPVEIQALWLAAL----GAELRLSQ-ALGE--------------PPRYAAVLERAHHSFKAQF 546  Deinococcus radiodu...
Q8KPV1  443 ---AKVGDW-VVTPRIGKPVEINALWYAAL----RSLAHFAR-CLGQp-------------STDYDQLAEATLQGFQR-F 499  Synechococcus elong...
Q8YNC7  458 ---AVVGGE-PITPRPGKPVEINALWYSALcwlsQWAERLSQmDLGDsvrl-------ekqGRRYAQQAQQVKASLQK-F 525  Nostoc sp. PCC 7120
Q7MGB4  541 ---AKINGQiPWSPRGPKANDIQALWFESL----QIAEQLALwQGDEa------------fAQHCHQLATKAQESFVTKF 601  Vibrio vulnificus Y...
P35573 1266 sdrARNRGI-PATPRDGSAVEIVGLSKSAV----RWLLELSKkNIFPyhevtvk-rhgkaiKVSYDEWNRKIQDNFEKLF 1339 human
O62334 1210 serAGNKGE-PATPRDGAAVELQGLAYRAL----KSLKNWKEqGVIQrsg--------vsdEWTWGFWAQKIRENFEKEF 1276 Caenorhabditis elegans
Q9W2H8 1362 sqkAGNKGR-PSTPRDGSAVELVGLQYAVL----RFMQSLAEkEVIPytgverkgpsgevtKWSYKEWADRIKNNFDKYF 1436 fruit fly
Q9HL89  386 ---AMVSGK-PVTPRIGKPIEINALWYNAL----SFYSRTAHdITGEd-------------TEMFSKLARRIKQKFRAKF 444  Thermoplasma acidop...
Q973T3  386 ---ASYDSH-VVTPREGAAVEINALWYNAL----MIMDFFAN-IVDDk-------------NSMYKELAEKTKASFNEKF 443  Sulfurisphaera toko...
Q8TMM8  426 ---AKVGEW-AVTPRAGKACEVNALWYNAL----KTASYMGT-LLGEd-------------ISSYETLAAGVASNFENTF 483  Methanosarcina acet...
Q8XHY8  432 ---VRVNGI-VVTPRHGKPVEINALWYNAL----KIAALLKNkFEKEe-------------KNEYEELAKKVKDSFTKTF 490  Clostridium perfrin...

Q06625 1325 yvpEDpsqdadyd------------------------------------------------------------------v 1338 Saccharomyces cerev...
Q9RXW4  547 ---WNhaadltaaptatllglgqlgsslggalsdaldgdfvlddeprrdtssdalltvggrpgsgpvqsttgaselgvgh 623  Deinococcus radiodu...
Q8KPV1  500 ---WQ--------------------------------------------------------------------------- 501  Synechococcus elong...
Q8YNC7  526 ---WN--------------------------------------------------------------------------- 527  Nostoc sp. PCC 7120
Q7MGB4  602 ---WQ--------------------------------------------------------------------------- 603  Vibrio vulnificus Y...
P35573 1340 hvsEDpsdlne--------------------------------------------------------------------- 1350 human
O62334 1277 fvdKDsya------------------------------------------------------------------------ 1284 Caenorhabditis elegans
Q9W2H8 1437 fvsESetc------------------------------------------------------------------------ 1444 fruit fly
Q9HL89      --------------------------------------------------------------------------------      Thermoplasma acidop...
Q973T3  444 issWG--------------------------------------------------------------------------- 448  Sulfurisphaera toko...
Q8TMM8  484 ---WN--------------------------------------------------------------------------- 485  Methanosarcina acet...
Q8XHY8  491 ---WN--------------------------------------------------------------------------- 492  Clostridium perfrin...

Q06625 1339 saklgvNRRGIYRDLYKSGKPy---EDYQLRPNFAIAMTV-----AP--ELFVPEHAIKAITIADEVLRGPVGMRTLDPS 1408 Saccharomyces cerev...
Q9RXW4  624 rpgaapAQPAVLADVIQPSGE----QDLSVRPNAVIALAL-----AD--TPVVDEQLDAVLAQTERELLTPVGLHTLSPH 692  Deinococcus radiodu...
Q8KPV1  502 ------ADRGYCFDVLDSPTG----SDASLRPNQLLAISLgcdrdQP--ALLTPDQQQQVVTLCGQQLLTSFGLRSLDPR 569  Synechococcus elong...
Q8YNC7  528 ------PQLGYLYDTIDLDDR----RNVQIRPNAILALSL-----HH--CGFSQQQGQQILDLATYCLLTPYGLRSLDPA 590  Nostoc sp. PCC 7120
Q7MGB4  604 ------PEERCLADCLRHGDE----ADLSLRPNQLMALTI-----PMkrNLLAAEIGQHLVKNCVEQLLFPWGICSLAQS 668  Vibrio vulnificus Y...
P35573 1351 khpnlvHKRGIYKDSYGASSPw---CDYQLRPNFTIAMVV-----AP--ELFTTEKAWKALEIAEKKLLGPLGMKTLDPD 1420 human
O62334 1285 ---efvNRREIIKDSVGSTLGf---TDFQLRCNFGIALAV-----AP--DLMDPKKAWKALDSAE-VLLGPLGMKTLDPT 1350 Caenorhabditis elegans
Q9W2H8 1445 ---svaNKKLIYKDSYGATQSw---TDYQLRCNFPITLTV-----AP--DLCNPQNAWRALERAKKYLLGPLGMKTMDPE 1511 fruit fly
Q9HL89  445 ------IKGDAVLDVSDP-------DDMKFRPNFLIPYFL-----PY--PLLNDRK---FVDLAWEKLVTPYGLRTLSPD 501  Thermoplasma acidop...
Q973T3  449 -----------AYDYLDPYLI----PDKSIRPNQLFALSL-----PF--SIMSEDIGKIMLITIENELLRPFGLSTLSRR 506  Sulfurisphaera toko...
Q8TMM8  486 ------PESNCLFDLIHQDEAgnqvKDPAIRPNQIFAVSL-----PY--TMLSPEKEKAIVDRVEKDLLTPFGLKTLSSD 552  Methanosarcina acet...
Q8XHY8  493 ------EDRKYLYDVVNNHE-----KDDSLRPNQIWAVSL-----PF--TMLDREKEKHIVQKVFEELYTPYGLRSLSRD 554  Clostridium perfrin...

Q06625 1409 DYNYRPYYNN-GEDSDDFAtskgrnYHQGPEWVWLYGYFLRAFHHFHFktsprcqnaakekpssylYQQLYYRLKGHRKW 1487 Saccharomyces cerev...
Q9RXW4  693 DPRYLGNYGG-PQLLRDAA------YHQGTVWPWPLASYVELLLSRGE------------------LNRARAALAGLTGH 747  Deinococcus radiodu...
Q8KPV1  570 HPQYQGHYGG-DQTQRDAA------YHQGTVWAWLLGSFAIAHYAAFGd-----------------RALAAQVLQPIAHH 625  Synechococcus elong...
Q8YNC7  591 DPEYLGRYEG-SPEKRDRA------YHQGTVWTWLIGPFIRSWQRFYPeqp-------------lpFD-WQPLLD---HF 646  Nostoc sp. PCC 7120
Q7MGB4  669 HQDFHPYHDNrSEYHKDAA------YHNGTIWGWNAGFTVSALCQFGQqdfa----------yqlsKNLAK-------QI 725  Vibrio vulnificus Y...
P35573 1421 DMVYCGIYDN-ALDNDNYNlakgfnYHQGPEWLWPIGYFLRAKLYFSRlmgpe--------ttaktIVLVKNVLSRHYVH 1491 human
O62334 1351 DWAYNGYYNN-DDDGTDKKtakgwnYHQGPEWLFVAGYYLQARLRIGDilggs--------ekqyaIRQVQERLGNAYKH 1421 Caenorhabditis elegans
Q9W2H8 1512 DWNYRANYDN-SNDSTDCTvahganYHQGPEWVWPIGFYLRARLIFAKkcgh----------ldetIAETWAILRAHLRE 1580 fruit fly
Q9HL89  502 DPDYVPTYSG-PQPERDMA------YHNGTVWPWLAGIFITAAVKTGYdkh-------------alLEKFAPLFS----- 556  Thermoplasma acidop...
Q973T3  507 DPKYKPTYRG-DRKSRDEA------YHNGPIWPWLIGAYVDAKLKIESdvik----------nkliLDVIKPLLE----- 564  Sulfurisphaera toko...
Q8TMM8  553 HPLYKGQYRG-DALTRDTA------YHNGTVWPWLLGAYVKAYLKVNNssk-------------ssLEEMRVLLEGFDAH 612  Methanosarcina acet...
Q8XHY8  555 NKDYHGIYIG-KLFDRDMA------YHQGTTWAFPLGGFFTAYCKVNDysk-------------eaVDLVDSLMRDMEDH 614  Clostridium perfrin...

Q06625 1488 IFESVWAGLTELTN----KDGeVCNDSSPTQAWSSACLLD 1523 Saccharomyces cerevisiae S288C
Q9RXW4  748 VWEAGIGHVSEVFS----GDA-LTPGGCPFQAWSVAELLR 782  Deinococcus radiodurans
Q8KPV1  626 LQTAGLGTISEIFD----GDApFLPRGCIAQAWSVGEILR 661  Synechococcus elongatus PCC 7942
Q8YNC7  647 LSDACLGSISEIFD----GDPpHRARGAVAQAWSVAEVIR 682  Nostoc sp. PCC 7120
Q7MGB4  726 LTQGHRGTMSENLDafqqDENaLVMTGTYAQAWSVSEFAR 765  Vibrio vulnificus YJ016
P35573 1492 LERSPWKGLPELTN----ENAqYCPFSCETQAWSIATILE 1527 human
O62334 1422 IISSPWRSLPELTN----ADGeYCMQSCAAQAWSVGCLIE 1457 Caenorhabditis elegans
Q9W2H8 1581 LQTSHWRGLPELTN----DNGsYCGDSCRTQAWSVAAILE 1616 fruit fly
Q9HL89  557 -----MSRIPEIFD----GSGtGIPKGCIMQAWSHGEIAR 587  Thermoplasma acidophilum
Q973T3  565 YAKKNRGFIPELYE----DVPpYLPAGCIAQAWSVAEVYR 600  Sulfurisphaera tokodaii
Q8TMM8  613 LEVAGIGTISEVFD----GDYpHAPGGSIAQAWSVAEILR 648  Methanosarcina acetivorans
Q8XHY8  615 IKDQCLGSIAEIFD----GDNpYKARGCYAQAWSVGEMLR 650  Clostridium perfringens
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