Conserved Protein Domain Family
DLIC
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pfam05783: DLIC (this model, PSSM-Id:283447 is obsolete and has been replaced by 368612)
Dynein light intermediate chain (DLIC)
This family consists of several eukaryotic dynein light intermediate chain proteins. The light intermediate chains (LICs) of cytoplasmic dynein consist of multiple isoforms, which undergo post-translational modification to produce a large number of species. DLIC1 is known to be involved in assembly, organization, and function of centrosomes and mitotic spindles when bound to pericentrin. DLIC2 is a subunit of cytoplasmic dynein 2 that may play a role in maintaining Golgi organization by binding cytoplasmic dynein 2 to its Golgi-associated cargo.
Links
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Statistics
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PSSM-Id: 283447
Aligned: 6 rows
Threshold Bit Score: 794.061
Created: 16-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q90828    33 DDGQNLWSCILSEVSTRSRSKLPSGKSVLLLGEDGAGKTSLIGKIQGIEEYKKGRGMEYLYLNVHDEDRDDQTRCNVRIL 112 chicken
Q16RB5    26 DPKENLWSAILSEVQTQSSTKLPSNKSVLVLGDNASGKTTLIAKLQGVEDPKKGSGLEYAYIDVRDEYRDDVTRLGVWIL 105 yellow fever mosquito
Q29HJ5    27 AEKENLWSAILNEVQTQGSTKLPANKSVLVLGDNATGKTTLIAKLQGVEDPKKGSGLEYAYIDVKDEYRDDMTRLGVWVL 106 Drosophila pseudoob...
Q6PDL0    30 EEGQSLWSSILSEVSTRARSKLPSGKNILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWIL 109 house mouse
Q1LUM9    29 EDGQNLWSSILSEVSTRSRSKLPSGKNVVVMGEVGSGKTTLVAKLQGVEEYMKGRGLEYLYFNVHDDDIDDQSRCNAWVL 108 zebrafish
AAI54269  26 DEGQNLWSSILSEVSTRSSSKLPSGKNVLLFGEDGSGKTTLMSKLQGAEHNKKGRGLEYLYLNVQDEDIDDLTRCSVWIL 105 zebrafish

Q90828   113 DGDLYHKGLLKFAMEANSLKDTLIMLVVDMSRPWTAMDSLQKWASVVREHIDKLKIPPEEMKEMEQKLVRDFQEYVEPGE 192 chicken
Q16RB5   106 DGDPGHTNLLKYALNETNYAHTLVILTLSMTTPWSWVDQLEHWIKMLDDHIAGLKIDPEERQQCRQRLVTVWQSYCDTID 185 yellow fever mosquito
Q29HJ5   107 DGDPGHTNLLHFALNETNYAHTLVILTVSMTQPWGWLEQLNHWIKVLGQHIESLPLEAKDKEMARQRLATTWQSYCEVGD 186 Drosophila pseudoob...
Q6PDL0   110 DGDLYHKGLLKFAVSAESLRETLVIFVADMSRPWTIMESLQKWASVLREHIDKMKIPPEEMRDLERKFMKEFQDYIEPEE 189 house mouse
Q1LUM9   109 DGDLYHKGLQKFAISLENLEDSLILFVVDLSRPWLALDSLQKWGSVVRDFVDKLRVPPETMRELEHRLTKQFQEYVEPGS 188 zebrafish
AAI54269 106 DGDLYHKGLLKFAVTAESLKDSLAVFVVDMSRPWTIMESLQKWTSVLREHVDKLRIPPEEMREMEQRMVKAFQEYVEPEE 185 zebrafish

Q90828   193 DF-PASPQRRNTSLQEDKDDSVILPLGADTLTCNLGIPVVVVCTKCDAISVLEKEHDYRDEHFDFIQSHIRRFCLQYGAA 271 chicken
Q16RB5   186 ELdPGSPIKRTNRLSSVDDDLDALPLPEGVLTTNLGLDVVVVVTKTDYMTTLEKELDYRDEHFDFMQQWIRRFCLVYGAS 265 yellow fever mosquito
Q29HJ5   187 DLdPGSPVKRTMRNNSIDED-DLLPLTEDALITNLGLDIVVVVTKTDYMTTLEKEYEYRDEHFDFIQQWIRSFCLRTGAS 265 Drosophila pseudoob...
Q6PDL0   190 GC-QGSPQRRGPLTSGSDEDSVALPLGDNVLTHNLGIPVLVVCTKCDAMSVLEKEHDYRDEHLDFIQAHLRRFCLQYGAA 268 house mouse
Q1LUM9   189 DL-DAVPQRRNPES---DEESVLLPLGENTLTHNLGLPIVVVCTKCDAISTLEKEHDYKDEHLDFIQSHIRRFCLQYGAA 264 zebrafish
AAI54269 186 AT-PGSPQRRAPAAAG-EDESVLLPLADNVLTHNLGIPMLIVCTKCDAVNVLEKEHDYKEEHFDFIQSHIRRFCLQYGAG 263 zebrafish

Q90828   272 LIYTSVKENKNIDLVYKYIVQKLYGFPFNVPAVVVEKDAVFIPAGWDNDKKIGILHENFQTLKAEDSFEDSIRKPPVRKF 351 chicken
Q16RB5   266 LFYTSVKEDKNCDLLYKYLTHRIYGLPFRTPALIVEKDAVLIPAGWDNMKKINILYENMQSCKPDDYYNDIIAQPPSRKT 345 yellow fever mosquito
Q29HJ5   266 LFYTSVKEDKNCDLLYKYLTHRIYGLPFRTPALVVEKDAVLIPAGWDSLKKISILYENMHGIKAESPYSDVIKAPPTRKA 345 Drosophila pseudoob...
Q6PDL0   269 LIYTSVKEEKNLDLLYKYIVHKTYGFHFTIPALVVEKDAVFIPAGWDNEKKIAILHENFTTVKPEDAYEDFIVKPPVRKL 348 house mouse
Q1LUM9   265 LLYTSMKENKNLDLLYKYLVHRLYGFPFNSPAQVVEKDSVFIPSGWDNEKKIAILHENFQMVKAEDSFEDVIVKPPVRKF 344 zebrafish
AAI54269 264 LIYTSVKEEKNLDLLYKYMVHKIYDFQFSSPALVVEKDAVFIPSGWDNDKKIGILHENFTTVRPEDPFEDFITKPPVRKL 343 zebrafish

Q90828   352 VHEKEI--VAEDDQVFLMKQQSQLaKQPPTAAgRPvDASPRVPGGSprtpNRSVTSNVASVTPIPAgSKKIDPNMKAGAT 429 chicken
Q16RB5   346 VSNREIevQTEEEQAFLSRQLQLL-QQGQTPT-RG-ESPMRSQNSA----SKTSPRTPGSAGAQGS-PKKVDGKLNPGTP 417 yellow fever mosquito
Q29HJ5   346 VSNREVevQTEDEQTFLARQQEILkQAGQ--D-RG-ESPLRSQGGGgvggNKSVPRTPGSTG-QSS-PKKIDPKLTPATP 419 Drosophila pseudoob...
Q6PDL0   349 VHDKEL--AAEDEQVFLMKQQSLLaKQPATPT-RTsESPARGPSGSprtqGRGGPASVPSASPGTS-VKKPDPNIKNNAA 424 house mouse
Q1LUM9   345 VHEKEV--QAEDDQVFLVKLQSLLsKQPPVTAgRPvDPTNRAPTGSprttNRSAAANVANVMPMQSgTKKIDPNMKGGQT 422 zebrafish
AAI54269 344 VHDKEI--SAEDEQVFLMKQQSLLaKQPATPT-RGtESPARTASGSprptGRTGPTNVASVSPMTA-VKKPDPNMKGAAA 419 zebrafish

Q90828   430 S-EGVLANFFNSLLSKKTGSPGGPGGvggspGGGSAGGTGSNLPPSAKKSGQKPVLTDVQAELDRISRKPEMVS--PTSP 506 chicken
Q16RB5   418 SgEGVLANFFNSLLHKKSGSPAAASL-----AGTGVSPRATNGGDMVTASEKISMRTDAAMELDRLARSVKKDLd-FPAQ 491 yellow fever mosquito
Q29HJ5   420 GgEGVLANFFNSLLHKKSGSPGGGGGpp-gaGTPTGTTRTSNGTDSLMTPEKLAVRSDAAAELDRLSRSVKKEId-L-SQ 496 Drosophila pseudoob...
Q6PDL0   425 S-EGVLASFFNSLLSKKTGSPGSPSA------GG--------VQSTAKKSGQKTVLSNVQEELDRMTRKPDSMVt-NSS- 487 house mouse
Q1LUM9   423 S-EGVLANFFNSLLTKKAGSPGP---------GGQPAGGGSNTPGTVRKSGSKLGLTDVQAELDRISNKSDLDSsaPNAT 492 zebrafish
AAI54269 420 N-EGVLANFFNSLLSKKTGVPGSPGTp------GAGAGTGTGVQGSAKKTGQKPGLTDVQAELDRMTRKPDSLVt-ANNt 491 zebrafish

Q90828   507 TSP 509 chicken
Q16RB5   492 TDC 494 yellow fever mosquito
Q29HJ5   497 SEC 499 Drosophila pseudoobscura
Q6PDL0   488 TEN 490 house mouse
Q1LUM9   493 TPP 495 zebrafish
AAI54269 492 pat 494 zebrafish
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