Conserved Protein Domain Family
IER

?
pfam05760: IER (this model, PSSM-Id:283429 is obsolete and has been replaced by 461732)
Immediate early response protein (IER)
This family consists of several eukaryotic immediate early response (IER) 2 and 5 proteins. The role of IER5 is unclear although it play an important role in mediating the cellular response to mitogenic signals. Again, little is known about the function of IER2 although it is thought to play a role in mediating the cellular responses to a variety of extracellular signals.
Statistics
?
PSSM-Id: 283429
Aligned: 21 rows
Threshold Bit Score: 260.913
Created: 13-Jul-2015
Updated: 5-Aug-2015
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q99J55         1 MECALDAQSLISISLRKIHSSRTQRGGIKLHKNLLVSYVLRNARQLYLSERYAELYR----------R-----------Q 59  house mouse
Q6NYT3         1 MECAVDAQSLISISLRKIHNSRTQRGGIKLHKNLLVSYVLRNARQVYMNEKYAEIYR----------M-----------Q 59  zebrafish
O89113         1 MEFKLEAHRIVSISLGKIYNSRVQRGGIKLHKNLLVSLVLRSARQVYLSDPCPGLYL----------A-----------G 59  house mouse
Q5VY09         1 MEFKLEAHRIVSISLGKIYNSRVQRGGIKLHKNLLVSLVLRSARQVYLSDPCPGLYL----------A-----------G 59  human
XP_011615873   5 aECAVDAESLISISLMKIHNSRTQRGGIKLHKNLLVSYVLRNARQVYIKEKYAEVYR----------I-----------Q 63  torafugu
XP_005470593   5 MECAVDAQSLISISLMKIHNSRTQRGGIKLHKNLLVSYVLRNARQVYIKEKYAEIYR----------M-----------Q 63  Nile tilapia
CAF96710       1 MECAVDAQSLISISLMKIHNSRTQRGGIKLHKNLLVSYVLRNARQVYIKEKYAEIYR----------M-----------Q 59  spotted green p...
XP_007257047   5 aECAVDAQSLISISLRKIHNSRTQRGGIKLHKNLLVSYVLRNARQVYMNEKYAEIYR----------M-----------Q 63  Mexican tetra
XP_003785699   1 MEFKLEAHRIVSISLGKIYNSRVQRGGIKLHKNLLVSLVLRSARQVYLSDPCPGLYLagpagtpappP-----------Q 69  small-eared galago
XP_012366327   1 MEFKLEAHRIVSISLGKIYNSRVQRGGIKLHKNLLVSLVLRSARQVYLSDPCPGLYL----------AgpagtpapppqQ 70  northern white-...
Q99J55        60 QQQQQqqpphhqhq--------hlayaapgMPASA-----ADFGPLQ------Lggg---gdAEARepvaRHQLHQLHQL 117 house mouse
Q6NYT3        60 QYEEV-------------------------MTVCNe---iQELNPLD------La------eDCED----QTADCCGSAS 95  zebrafish
O89113        60 PAGTPavpppqqpgepvagppsgwgeppppVARAAwpepePQPQPQP------QrpsvchtpGAGSsepvAAVAGSGEAL 133 house mouse
Q5VY09        60 PAGTPapppqqqpgepaagppagwgeppppAARASwpe----tePQP------ErssvsdapRVGDevpvATVTGVGDVF 129 human
XP_011615873  64 QYEEV-------------------------MAVCNe---iEELNPLEt-----Aa------eDMDNgdqaRGGCCSEESS 104 torafugu
XP_005470593  64 QYEEV-------------------------MTVCNe---iQELNPLD------Le------aEDAEdeeqARAACCAEEA 103 Nile tilapia
CAF96710      60 QYEEV-------------------------MAVCNe---iQELDPLEl-----Ea------gDADDgdqaRGVCCGEESS 100 spotted green p...
XP_007257047  64 QYEEV-------------------------MTVCNe---iQELDPLDvvaggaAa------dECEDagvaEQQQCCAGGM 109 Mexican tetra
XP_003785699  70 QPGEPaavppagwgeppppaaraawretepQPQPQp---qPERTAVL------Da------qWVGGaepaTSVTRVGDAL 134 small-eared galago
XP_012366327  71 QSGEPaagppag-----------wgeppppAARASw----PETEPQP------ErsyvsdapRVVEevpvATVTGVGDVL 129 northern white-...
Q99J55       118 HQLHlqqq-lhqhQHpaprgctAAApva--------vaGAPAGC--------------------AGALSELPGC-----A 163 house mouse
Q6NYT3        96 ESAS---------LC-------GAL-------------LPAVGH--------------------QTSPAAQHIQ-----P 121 zebrafish
O89113       134 RGGEedsaaaawgRVerpraasSGGgsd--------acPEGPRA--------------------VRRPCGCPPA-----V 180 house mouse
Q5VY09       130 QGGEadateaawsRVegprqaaAREaegtag--gwgvfPEVSRA--------------------ARRPCGCPLG-----G 182 human
XP_011615873 105 LCGSa---------Chr----dAA-------------------H--------------------ARALSALPCC-----P 127 torafugu
XP_005470593 104 SACGs--------PChr----gAA-------------------H--------------------CRAAGTVAGC-----S 127 Nile tilapia
CAF96710     101 PCGSa--------------------------------cHRDAAH--------------------ARAASALPGC-----P 123 spotted green p...
XP_007257047 110 AGGQa-------------------------------------------------------------SLCGAQPC-----S 123 Mexican tetra
XP_003785699 135 QGREa--------DAae----aAWGs------------VEGPRGaaaagagdpvrgsdvfpegpARRPSACPPGgedqrG 190 small-eared galago
XP_012366327 130 QGREvdat-eaawSHveg-prpAAAreaegpargwgvfPEGSRA--------------------ARRPCGCLLG-----G 182 northern white-...
Q99J55       164 alqppHGAPHRGQHL--EPlQPGpaplpppapaalcprdprvpaacsapsvlpgaapstvaassppastapssstgfyrG 241 house mouse
Q6NYT3       122 asacsVPLALQSEEVckAApEPSfyrs-------------------------------------------------ccaE 152 zebrafish
O89113       181 e------------------eRSSe-------------------------------------------------------D 187 house mouse
Q5VY09       183 edppgTPAATPRAACccAP-QPAe-------------------------------------------------------D 206 human
XP_011615873 128 ----------RLEDVskEP-ENPyyrs-------------------------------------------------cfmQ 147 torafugu
XP_005470593 128 ----------LLEDGckEP-EPSyyrs-------------------------------------------------ccmE 147 Nile tilapia
CAF96710     124 ----------RLEDAnkEP-ESAyyrs-------------------------------------------------ccaQ 143 spotted green p...
XP_007257047 124 -----LPSAP--EEAckTS-ETLf-------------------------------------------------------Y 140 Mexican tetra
XP_003785699 191 -----AAAASPGADCccAP-RPVv-------------------------------------------------------D 209 small-eared galago
XP_012366327 183 -----ED---------------Pp-------------------------------------------------------G 187 northern white-...
Q99J55       242 AYPAPs-----------dFGVHCsSQTTVLDLDTHVVTTVENGYLHQDC-Ca---SAH-CPccgQGAPGPglasaAgCKR 305 house mouse
Q6NYT3       153 AYPVSncdf------spvNNMHC-NKTTVLDLDTHVVTTVENGYLHQDC-C----ASL-QQc-cQGAQSP-----A-KKR 212 zebrafish
O89113       188 GSPAPpapc-----prkrGAAGV-G-----GGR-------------ASC------------------SAPgstplKkPRR 225 house mouse
Q5VY09       207 EPPAPpavc-----prkrCAAGV-G-----GGP-------------AGC------------------PAPgstplKkPRR 244 human
XP_011615873 148 PYPLSncaq-----fvtnGSAQC-TKTTVLDLDTHVVTTVENGYVHEDCfCd---SPQ-CG---QNTQS------TtKKR 208 torafugu
XP_005470593 148 APPAPlceq-----cpanSSAHC-NKTTVLDLDTHVVTTVENGYLHQDC-Cc---DALqCG---QSAQSP-----A-KKR 208 Nile tilapia
CAF96710     144 PYPAShcaqv----taggGSAQC-TKTTVLDLDTHVVTTVENGYLHQDC-CcccdAPQ-WG---QIAQSPt------KKR 207 spotted green p...
XP_007257047 141 RSCCAepypppppspcdfSPAHC-NKTTVLDLDTHVVTTVENGCLHQDC-Cc---TPL-QP-----CSSP-----SsKKR 204 Mexican tetra
XP_003785699 210 ESPAPp-----------------------------aVCPRKRGAAGVGG-Gp---AGC-QA---PGATPL-----KkPRR 247 small-eared galago
XP_012366327 188 TPAATp-----------rAA----------------------------C-Cc---APR-PT---EDEP-P-----ApP-- 212 northern white-...
Q99J55       306 KYYP----GQEEEDDEEDAgDlgaeppggtpFAPC-KRARfEDfCPDSSP---DASNISNLISIFGSGFSGLVSRQPDs- 376 house mouse
Q6NYT3       213 KLDF----GYYVSEIEEAP-D----------FTPC-KRAKfED-SSYAITeplDTSNISNLISIFGSGFSGLVSRQAD-- 273 zebrafish
O89113       226 NSEE---------QPVTg--E-------------------------DDTDeemETGNVANLISIFGSSFSGLLRKSPAgg 269 house mouse
Q5VY09       245 NLEQ---------PPSGg--E-------------------------DDDAeemETGNVANLISIFGSSFSGLLRKSPGgg 288 human
XP_011615873 209 KVEF----SCCVSDAVDVSdF----------IATR-KRLK-RDdCPFSNPdytDASNITNLISIFGSGFSGLLSRQSD-- 270 torafugu
XP_005470593 209 KVEF----GCCASDAEEAHdF----------TAAR-KRAK-REdCSYSAPdytDTSNISNLISIFGSGFSGLLSRQAD-- 270 Nile tilapia
CAF96710     208 KVEF----GGCAPDAEEVS-D----------FTATrKRPR-REdGPFSGPdhaDASNITNLISIFGSGFSGLLSRQSD-- 269 spotted green p...
XP_007257047 205 KVSDysgcGYYAPELEDVSvD----------PAPC-KRAK-LEdCCSDCLvdlDTANISNLISIFGSGFSGLVSRQAD-- 270 Mexican tetra
XP_003785699 248 NLEE----QQ---------------------------PGR-GEd---DDPedmETGNVANLISIFGSSFSGLLRKSPGg- 291 small-eared galago
XP_012366327 213 --------------------------------AVCg--------GEDEDAeemETGNVANLISIFGSSFSGXLRKSPGg- 251 northern white-...
Q99J55       377 SEQ-----------PppLN--------GQL-CAKQALASLGAWTRAIVAF 406 house mouse
Q6NYT3       274 LEQ-----------A--LN--------GQF-CSKQALASLGAWTRAIVAF 301 zebrafish
O89113       270 REE-----------EeaEEggpeaaepGQIcCDKPVLRDMSPWSTAIVAF 308 house mouse
Q5VY09       289 REE-----------EegEEsgpeaaepGQIcCDKPVLRDMNPWSTAIVAF 327 human
XP_011615873 271 MEQ-----------I----------------CSKQVLASLGAWTRAIVAF 293 torafugu
XP_005470593 271 LEQ-----------I----------------CSKQALASLGAWTRAIVAF 293 Nile tilapia
CAF96710     270 MEQ-----------I----------------CSKQVLASLGAWTRAIVAF 292 spotted green pufferfish
XP_007257047 271 FEQ-----------A--FN--------GQF-CSKQALASLGAWTRAIVAF 298 Mexican tetra
XP_003785699 292 GREeeegaesgpeaA--EP--------GQIcCDKPVLRDMNSWSTAIVAF 331 small-eared galago
XP_012366327 252 GREeeegeesgpeaA--EP--------GQIcCDKPVLRDMNPWSTAIVAF 291 northern white-cheeked gibbon
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap