3R3Q,2F0R


Conserved Protein Domain Family
UEV
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pfam05743: UEV (this model, PSSM-Id:283415 is obsolete and has been replaced by 399041)
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UEV domain
This family includes the eukaryotic tumour susceptibility gene 101 protein (TSG101). Altered transcripts of this gene have been detected in sporadic breast cancers and many other human malignancies. However, the involvement of this gene in neoplastic transformation and tumorigenesis is still elusive. TSG101 is required for normal cell function of embryonic and adult tissues but that this gene is not a tumour suppressor for sporadic forms of breast cancer. This family is related to the ubiquitin conjugating enzymes.
Links
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Statistics
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PSSM-Id: 283415
Aligned: 23 rows
Threshold Bit Score: 112.346
Created: 26-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3R3Q_A  33 TFHDSLALLDNFH----SLRPRTRVFTH-SDGTPQLLLSIYGTISTGEDgsspHSIPVIMWVPSMYPV------KPPFIS 101 baker's yeast
Q59WF8  24 VYAHVFQFLQLHLkknlNFKIRTQIYTSsGSGEPNLLINLFGTIQINEQ----IGTPIEIWVPFAYPYvdyenkGAPIVY 99  Candida albicans
Q75EU1  32 TFHDVVIALRAYK----KLRPRTRVFTD-EAGRSKLLLCLYGKV---------GNVDVLIWIPFEYPN------VAPHAY 91  Eremothecium gossypii
Q6FS29  27 VFHDAVQTLTEFK----NLRPRTRVFTD-EDGSPRLLLCLYGGIPIEQG----LDVPVLIWIPESYPI------AKPLLF 91  Candida glabrata
Q5KKQ1  24 ITQEVLYVLQQRR----TLAVKTDAFTF-DSGHTALLLLLHGTLPVTYRga-iYQIPIHLWVPHEYPR------APPLIF 91  Cryptococcus neoformans
Q5BAA9  33 TYYDVANVLAKFP----TLAPETAVYTY-ENGFSALLLQLSGTLPVTFRgt-vYKFPIALWIPNTYPR------EPPIVY 100 Aspergillus nidulans
Q4UHS4  19 LMCDINGLFGKYH----NFSCSM------STSFDCHRLNISGTVPYTFSgf-tLNAPLLIQVFSDYPF------SCPSFF 81  Theileria annulata
Q4N7T6  34 LMIDLDGLFLKYH----NFKCSM------STSFDGHRLNIVGLVPYTFSgf-tVNAPLVIQVLSDYPF------STPLFW 96  Theileria parva
Q6ESB7  45 IRNHLVALADAFP----SLHPKAALFTH-NDGRAAHLLQADGTIPIHHAga-sYNLPAVLWLPEPYPR------SPPLVF 112 Japanese rice
Q9LHG8  37 IRQHLLNLISSYP----SLEPKTASFMH-NDGRSVNLLQADGTIPMPFHgv-tYNIPVIIWLLESYPR------HPPCVY 104 thale cress

3R3Q_A 102 INLENFDmntissSLPIQE-YIDSNGWI-ALPILHAWDP--AAMN-----LIMVVQeLMSllhePPQDQA 162 baker's yeast
Q59WF8 100 IVPDHSKg----wYLKPNN-NVDTQGMF-YHPYLTRWHRecLRSNpdslnMFSLVE-LANviyrSVTTDS 162 Candida albicans
Q75EU1  92 IDLEANKg----rSIIVNQ-RLDGDGLF-YLPILGHWHP--QNCN-----VVKLVQdLEQ----AIMAQE 144 Eremothecium gossypii
Q6FS29  92 IDLELLDkd---lQLATNE-SVEPDGRV-HTRLLRQWNP--QSAN-----LFNVIQdLAD----MCNAIA 145 Candida glabrata
Q5KKQ1  92 VMPTKDM------GVRKSR-EVEPSGRV-REEVVEGWWRawEVKN-----LDMLLKhLAD----VFSAAP 144 Cryptococcus neoformans
Q5BAA9 101 VKPTQDM------VVRVGQ-HVTLEGRV-YHHYLAHWGGawERSS-----LLDLLSiLQD----VFAKEP 153 Aspergillus nidulans
Q4UHS4  82 VPSRNT-------KIVKNHpNVDLRGNV-TLKYLDEWNH---TSK-----LVQAVDhLCY----AFSKIS 131 Theileria annulata
Q4N7T6  97 IRGHNI-------KIVKNHpNVDLRGNV-TLKYLDEWNH---TSK-----LVQAVDcLHY----AFNKMS 146 Theileria parva
Q6ESB7 113 LSPTRDM------VIKPHHpLVDRSGLVaNAPYLRSWVF--PSSN-----LVDLVRsLSH----LFGLDP 165 Japanese rice
Q9LHG8 105 VNPTADM------IIKRPHaHVTPSGLV-SLPYLQNWVY--PSSN-----LVDLVSdLSA----AFARDP 156 thale cress
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