Conserved Protein Domain Family
LAP1C
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pfam05609: LAP1C (this model, PSSM-Id:283300 is obsolete and has been replaced by 461691)
Lamina-associated polypeptide 1C (LAP1C)
This family contains rat LAP1C proteins and several uncharacterized highly related sequences from both mice and humans. LAP1s (lamina-associated polypeptide 1s) are type 2 integral membrane proteins with a single membrane-spanning region of the inner nuclear membrane. LAP1s bind to both A- and B-type lamins and have a putative role in the membrane attachment and assembly of the nuclear lamina.
Links
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Statistics
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PSSM-Id: 283300
Aligned: 27 rows
Threshold Bit Score: 579.726
Created: 24-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q8BYU6        28 L-----------ENDP----SINSQ--------T---------QDTRVTPNNTAE--AQPLQPTSDLKEDhHEIGARAQE 73  house mouse
Q5PQX1       150 LrdaqslsedrgEDEPss-qPVTSQtvskktvrT---------PETSVM--SEDPisNLCRPPLRSPRPD---------- 207 Norway rat
XP_010589283 148 trrglrnsysseEDDPss-qTVLSQpvskktvrT---------PEVPVVSEDRVL--SLCRPPLRNSRTD-SSYSTNGNS 214 African savanna...
XP_006089072 145 mtrrrlrdshsseeeelspqTVVSQ--------TvskktvrrtQETSVMSGDSVL--DLLRPPLRSPRSE---------- 204 little brown bat
XP_002920844 150 arrglrdspsseEDEPss-qTILSQ--------TipkktiqraQETPV--VSEDPiiSLCRPPLRSSRSE---------- 208 giant panda
XP_006907958 131 trralrdshfseEDEPsp-qTVLSQ--------Taskk-tirtQETLVA--SEDPviSLRRPPLRSSRSD-STYTTNGNT 197 black flying fox
XP_008541816 153 rdshssegeaggEDELfs-nTVLSQ--------TgskkiiqrtQETPGMSDDPVK--SLCRPPIRSSGSD-SAYKTNGNT 220 Equus przewalskii
XP_007639045 145 tsrrglrdsqssEDEPsssqTVTSQ--------Taskr-tvrtPDASMMSEDPIS--NLCRPPLRSPRSD-STYKTNGNS 212 Chinese hamster
XP_004883402 147 srrglrdslsseEDEPss-qTVTNQ--------Tvskk-svrtQEAPVT--SEDPviSLCRPPLRSTRSE---------- 204 naked mole-rat
XP_012658037 146 trkglrdshsseEDEPss-qTVLSQ--------TvskktdrrmQENPVVKEDLIS--SLCRPPLRSPRSE---------- 204 small-eared galago

Q8BYU6        74 HTDTGDRSESPEEPALEKPPLDkAELESSPSSQDTELGHHPHSEHGGGDALDLDPNCSQSDLGGRADAHLESSSVASPeg 153 house mouse
Q5PQX1       208 -------ASIVQHINPFEEGe--TE-DDLESSYS----------DVT-IRIRSRDSVESRDEAAVAAGHHPDSLWGLP-- 264 Norway rat
XP_010589283 215 KMSELEATSVQQKGSFSEEGETe------------EDDSDSSESDVTVGKVRSGDSVDSGDQTIRSASRYPESFWQSS-- 280 African savanna...
XP_006089072 205 ------ATSVPQKVNFSEEGD--TEEDDQDVSDS----------AVTSVKVRSGESLDSGDQTSR-PGQHLESFWQSS-- 263 little brown bat
XP_002920844 209 ------ATGVQQKVNFSEGGETe------------QDDQDSSDSDITTAKVRSGDSLDFGDQTTRSSSQYPESFWQSS-- 268 giant panda
XP_006907958 198 NMSELETTSVQQKVNFSEEGDTeEDEDNSDVSSD--------VTSVTSVKVGPGASVESEAQTS-GGSQYSDSFWQSS-- 266 black flying fox
XP_008541816 221 KMNELDATSVQQKFSFSEEGE--TEDDDQDSYDS--------------VKIRYGDSVNFGGQTSRSSSQHSESPWQSA-- 282 Equus przewalskii
XP_007639045 213 KMSEIEAV-STQPVHFSEEGETe---DDLESSYSD-----------TTVKVRSRNSVESRDEATRSSSYCQESSWRLP-- 275 Chinese hamster
XP_004883402 205 ------ASSVKQKVNFSEEGE--TEDDDQDGSYS----------DTTTVKVRSGDSVEPGDQTTRSSSQCPESIRRLP-- 264 naked mole-rat
XP_012658037 205 ------ATSIQQ-VDFSEGVFFf--------------------------------FFYFLDQISRSSGQYQESFWQSS-- 243 small-eared galago

Q8BYU6       154 agdrgeadehlesssaaptEGAGDRGEAGQELLAEDS------TDGQSLGHSNTGPG--NQDSLRR-RLPvPEAGSHEEE 224 house mouse
Q5PQX1       265 -------------------HSRGDFTAHENQPSL------------LPTGCQKNPQEwvEQAVRMRtRM--AYNN--IQK 309 Norway rat
XP_010589283 281 -------------------QSRDFTTAHDKQPSV------------LSSGYQKNLQEwvEQTPRIRsRM--QNDNTHVQK 327 African savanna...
XP_006089072 264 -------------------QSQ-DFKALDKQHSVPSSkyqknlQNIKISEHQKNLQErvDQTTRRRtKM--PNDS--FQK 319 little brown bat
XP_002920844 269 -------------------QSR-DFITLDKQPSV------------LSSGYQKTPQEwfEQPTRRRaRIH----NDNIQK 312 giant panda
XP_006907958 267 -------------------QSR-DVTALDKQHSVLS-----------GSVYQTSPREwvKQTTRIRtRMP----NDRLQK 311 black flying fox
XP_008541816 283 -------------------QNR-DFTALDKQPSV------------LSSGYQKTPQQrvEQTTRKRtWM--QNDS--VQK 326 Equus przewalskii
XP_007639045 276 -------------------QSQ-DFTAHENQPSV------------LNSRCQKNAQEwvEQVIRMRtRLL----QNNIQE 319 Chinese hamster
XP_004883402 265 -------------------QSQ-DSTAHNKQSSV------------LSSGYQKNPQEwfEHQIRMRtRMQ----SDSIQM 308 naked mole-rat
XP_012658037 244 -------------------RSQ-DLIAHNRRPSA------------LSLGHQKNSEEwvKQTTGIRtRN--QNDSN--QK 287 small-eared galago

Q8BYU6       225 TELVKEKQE-VAQDTLRKTDKKSLWTYGSVFLGCLIVAVVLSSVNSYYSSPAQQVPQNPALEAFLAQFGQLKEKFPGQSS 303 house mouse
Q5PQX1       310 SDFGNQSPStSRQQAAVQPPDESSVKIKWW--LLILVAALAMGIYWFFHTP--VVETT-AVQEFQNQMKQLQSKYQSQDE 384 Norway rat
XP_010589283 328 SALGNQSPSiSSRQVTGQPKTTGFM---PWRWLFLLIAVIAIGIFWSSRNP--EVETT-AVQEFQNQMKQLMNKYRGQDE 401 African savanna...
XP_006089072 320 SEFGNQSPStFSQHMTGQPKNASFVKMKWWWLPIPVLLILVLGSWWYTHVP--EVEGT-AVXEFQNQMKQLMIKYQGQDE 396 little brown bat
XP_002920844 313 TELGNWSPStSSQQVTGQPKSASFIKT--WWWLPVLIVSLAVGSFLFTPSP--EVGTT-AVQEFQNQMRQLMNKYQGQDE 387 giant panda
XP_006907958 312 LELRNRSPSaSSQHVTRQPQNASSVKIKWWWWLLVPIVVFAVGYWWYPLTP--EAETT-AVKEFQNQMKQLMNKYQGQDE 388 black flying fox
XP_008541816 327 SELWNQSPStSNQQVTGQPKNAPFVKTK-WWLLLVLIAALALGSFWLSPTP--EVETT-AVQEFQNRMKQLMKKYQGQDE 402 Equus przewalskii
XP_007639045 320 SEFGNQSPStSGQQPAEQPDNEPSVNRKRWLLGLVV--SLAIGLLWFFYTPAVQ---TTAVQEFQNQMKQLQSKYQSQDE 394 Chinese hamster
XP_004883402 309 SELGNQSPSlSSQQVAEQPRNEYFFKKKWFLCLLVVISVLVLWNFSFIHMPG--VETT-AVQMFQNQMKQLRNKYQGQDE 385 naked mole-rat
XP_012658037 288 SEFRNQSPStFTQQLTRQPKNASFVKMKLWW-PFFIIALLALGSFWFFYTP--EVETTAAVQEFQNQMNQLRSKYQGQDE 364 small-eared galago

Q8BYU6       304 FLWQRGRKFLQKHLNASNP-SEPATIIFTAAREGKETLKCLSYHVANAYTSSQKVTAVSIDGAERALQDSDTVKLLVDLE 382 house mouse
Q5PQX1       385 KLWKRGTTFLEKHLNSSLPrPQPAILLLTAAQDAAEVLKCLSEQIADAYSSFRSVRAIRIDGAGKAAQDSDLVKHEVDQE 464 Norway rat
XP_010589283 402 KLWKRSLTFLEKHLNSSIPrPQPAILLLTAARDAEEVLKCLSEQIADAYSSFRSVRAIRIDGTGKAAQDSDTVKLEVDQE 481 African savanna...
XP_006089072 397 KLWKRSLTFLEKHLNSSQPrPQPAILLLTAARDAEEALKCLSEQIADAYSSHRSVRAIRIDGTGRATEDSDAVKLEVDQE 476 little brown bat
XP_002920844 388 KLWKRSLTFLEKHLNSSQPrPQPAILLLTAARDAEEVLRCLSEQIADAYSSFRSVRAIRIDGAGKATQDSDVVKQEVDWE 467 giant panda
XP_006907958 389 KLWKRSQTFLEKHLNSSQPrPQPAILLLTAARDAEEVLKCLSEQIADAYSSFRSVRAIRIDGTGKATQDSDAVKLEVDQE 468 black flying fox
XP_008541816 403 KLWKRSLTFLEKHLNSSQPrPQPAILLLTAAQDAEQALKCLSEQIADAYSSVHSVRAIRIDGAGKATQDSDAVKLEVDQE 482 Equus przewalskii
XP_007639045 395 KLWKRGTTFLERHLNSSVPrPQPAILLLTAAQDAKEVLKCLSEQIADAYSSFRSVRAIRIDGAGKAAQDSDLVKQEVDQE 474 Chinese hamster
XP_004883402 386 KLWERSLMFLQKHLNSSHPrPQPAILLLTAAQDAEEALKCLSEQIADAYSSFRSVRAIRIDGTGKAAQDSDVVKLEVDQE 465 naked mole-rat
XP_012658037 365 KLWKRSLTLLEKHLNSSHPrPQPAVLLLTAARDAEEALKCLSEQIADAYSSFWSVRAIRIDGAGKAAQDSDTVKLEVDQE 444 small-eared galago

Q8BYU6       383 LSDGFENGHKAAVVHHFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEEETLEASVSPREIEEKVRDLLWAKFTNSE 462 house mouse
Q5PQX1       465 LTDGFRNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEEQTLEASLGLKEIEEKVRDFLKVKFTSSD 544 Norway rat
XP_010589283 482 LSNGFRNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEDETLETTLGLKEIEEKVRDFLRVKFTSSD 561 African savanna...
XP_006089072 477 LSNGFQNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEEETLGTSLGLKEIEEKVRDFLKVKFTNSN 556 little brown bat
XP_002920844 468 LSNGFRNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEEETLGTSLGLKEIEEKVRDFLKVKFTNSD 547 giant panda
XP_006907958 469 LTNGFRNGQNAAVVHRFESLPARSTLIFYKYCDHENAAFKDVALVLTVLLEEETLGTSLGLKEIEEKVRDFLRVKFTNSD 548 black flying fox
XP_008541816 483 LSNGFRNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEEETLETSLGLKEIEEKVRDFLKVKFTNSD 562 Equus przewalskii
XP_007639045 475 LSNGFRNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEEKTLKASLGLKEIEEKVRDFLKVKFTNSN 554 Chinese hamster
XP_004883402 466 LSNGFTNGQNAAVVHRLESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEEKTLGTSLGLKEIEEKVRDFLKVKFTSSS 545 naked mole-rat
XP_012658037 445 LSNGFKNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEEETLGTSLGLKEIEEKVRDFLKVKFTNSD 524 small-eared galago

Q8BYU6       463 SPTSYSHMDSDKLSGLWSRISHLVLPVQPVRNIEERGC 500 house mouse
Q5PQX1       545 TANSYNHMDPDKLNGLWSRISHLVLPVQPENALKAGSC 582 Norway rat
XP_010589283 562 TPDSYNHMDSDKLSGLWSRISHLVLPVQPENALKGGFC 599 African savanna elephant
XP_006089072 557 TPTSYKHMDPDKLSGLWSRISHLVLPVQPENALKRGIC 594 little brown bat
XP_002920844 548 TPNSYKHMDPDKLSGLWSRISHLVLPVQPENALKSGIC 585 giant panda
XP_006907958 549 APNSYKHMDPDKLSGLWSRISHLVLPVQPEDALKRGIC 586 black flying fox
XP_008541816 563 TPNSYKHMDPDKLSGLWSRISHLVLPIQPENALKGGIC 600 Equus przewalskii
XP_007639045 555 KASSYNHMDPDKLNGLWSRISHVVLPVQPENALKGGSC 592 Chinese hamster
XP_004883402 546 TPSSYNHMDPDKLNGLWSRISHLVLPVQPENALKRGIC 583 naked mole-rat
XP_012658037 525 TPNSYNHMDPDKLNGLWSRISHLVLPVQPENTLKRGIC 562 small-eared galago
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