Conserved Protein Domain Family
AF-4
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pfam05110: AF-4 (this model, PSSM-Id:282905 is obsolete and has been replaced by 461550)
AF-4 proto-oncoprotein
This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.
Links
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Statistics
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PSSM-Id: 282905
Aligned: 29 rows
Threshold Bit Score: 842.446
Created: 11-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
O88573          9 NEDRNLLRIREKERRNQEAHQEKEAFPEKAPLFPEPYK-T-AKGDELSSRIQTMLGDYEEMKEF---LSSKSHP-HRLDG 82   house mouse
XP_006003261    3 REDRNVLRMKERERRNQEIQQAGEAFPANSPLFPEPYKvT-SKEDKLSNRIQSMLGNYDEMKDL---MGDRSLQ-KLVGI 77   coelacanth
XP_006633106   42 EQDRNALKKKEWERRTQEVQQDEDLFSSGFNLFGEPYK-T-NKGDALANRVQNTLGNYDEMKDL---LTNHSNQsHLVGI 116  spotted gar
XP_004042541    3 REDRNVLRMKERERRNQEIQQGEDAFPPSSPLFAEPYKvT-SKEDKLSSRIQSMLGNYDEMKDF---IGDRSIP-KLVAI 77   western lowla...
XP_002664429   21 EQDRSALKKKEWERRTQEVQQDEDLFSTGFNLFGEPYK-T-NKGDALANRVQNTLGNYDEMKEL---LTSHSNQsHLVGI 95   zebrafish
XP_011609585    3 REDRNVLRMKERERRNQEIQQGGEAFPANSPLFPEPYKvS-SKEDKLSSRIQSMLGNYDEMKEP---LGD-TLT-K-ITS 75   torafugu
XP_002935317    3 REERNLLRLKERERRNQEIQQGEEAFPSDSPLFAEPYKvT-SKEDKLSNRIQSMLGNYDEMNEMnemITDRSLP-KLAGI 80   western clawe...
XP_007507324   84 DQDRNALKRKEWERRSQEVQQDEDLFASGFSLFGEPYK-T-NKGDALASRVQNTLGNYDEMKDL---LTNHSNQsQLVGI 158  gray short-ta...
XP_004076172   10 REDRNVLRMKERERRNQEIQQGGEAFPANSPLFPEPYK-VvSKEDKLSSRIQSMLGNYDEMKEP---IGD-TLP-KLGGK 83   Japanese medaka
XP_011478777   47 ESERSVLKRREWERRTQEVQQDEDLFSTGFNLFGEPYK-T-NKGDALASRVQNTLGSYEEMKDL---LTSHSNQsHLVGI 121  Japanese medaka

O88573         83 SED---------RPgkpryp-lghdrGNGAASSSLR--THV---------------------YHQP------IHTSAPGS 123  house mouse
XP_006003261   78 PKPtvp----stPDeksnqs-ffgesRHN----SSH--QGS---------------------KWTP------VGPAPGTS 119  coelacanth
XP_006633106  117 PKNsip----qtPVekseqssffsegQRNRMAPSHQ--SAT---------------------TSMP------PPSSTSLS 163  spotted gar
XP_004042541   78 PKPtvp----psADeksnp--nffeqRHG----GSH--QSS---------------------KWTP------VGPAPSTs 118  western lowla...
XP_002664429   96 PKNsvp----qtPVekpdqpgffpeaQRSRPALS-Q--PGS---------------------HSTS------MPPPPANT 141  zebrafish
XP_011609585   76 KPSnss----ssSEeklgpn-lfggdQRGISSSGSS--QSN---------------------KWTP------VGPAASGS 121  torafugu
XP_002935317   81 PKSavp---ptaPDdktgqg-yfgdqRHG----SSH--QSS---------------------KWTP------VGPAPSTS 123  western clawe...
XP_007507324  159 PKNsip----qtPTekneq--sffpdQRNRMIAPHQ--GSS-----------------------QS------V--PLLSS 199  gray short-ta...
XP_004076172   84 PSNss-----ssSEeklaap-lfggdQRG------S--ESS---------------------KWTP------VGPAPGGS 122  Japanese medaka
XP_011478777  122 PKGstannlqqtPS------------FSERPAAESQlfNEAlrgdmggggaegsgekrtgsvPSSSascsapMQPPAVAS 189  Japanese medaka

O88573        124 RPVG-NisH-SPKMAQprMEPSL--HTKIYDGPrl---tqDH----------LSqg-hCSR------KCD-RRAEGDS-- 176  house mouse
XP_006003261  120 L-------Q-SQKRSSsgL---HsgQRSSNSSGssgsssqRH----------DRet-hSSSsss-rkKNQ-HSTEHSKsh 175  coelacanth
XP_006633106  164 SSTLlHghQ-GNKKSRs-TEWSRgtHSSATGQPsqagg---------------qqcgrAKHnssshePSQtRYEDLFSsq 226  spotted gar
XP_004042541  119 --------Q-SQKRSSglQSGHSsqRTSAGSSSgtnssgqRH----------DResynNSGsss-rkKGQ-HGSEHSKsr 177  western lowla...
XP_002664429  142 IPGS-SvmHgHQGKKSrsSDWSQggHRSSGVq--------TT----------QAas-rGKHss--heQTS-NRHDQDqed 198  zebrafish
XP_011609585  122 As------Q-SQKRS------ALgsQRGNGGSSsssnssqRH----------GGev-rEKKssk-------hsGGSEHsk 170  torafugu
XP_002935317  124 SQSQ-KrsS-SS---------------SQGGHSrssgsnsSS----------QRhd-rDSYsss-rkKGQ-HSSEHSKsr 173  western clawe...
XP_007507324  200 VTSS-SshQ-NIRKp--rADWPRagHCSTITQAs-----qST----------GLpn-rMKQsnp-hdQPQgRYEDLFNcq 258  gray short-ta...
XP_004076172  123 T---------SQKRSg--------lQGGHGSQRssggsssSS----------QRge-rEKKssk-------hsGGSEHsk 167  Japanese medaka
XP_011478777  190 TATI-Ah-Q-NLKKSRnsMDWSRgcHGQSTQAAgli--lgSGqnrqgqlssgATgs-rGKTstt-eeQQIqRHEELFSsl 262  Japanese medaka

O88573        177 ----APERKlsplisslpspvpplspvhsr----------------lqgtskahssgvssksccvaKSSKDLVAKAQDKe 236  house mouse
XP_006003261  176 ssspSKPPAvgtlssshsrsq---------------------------------gsdhhskdrqrsKSPHDPDANWDSPs 222  coelacanth
XP_006633106  227 gdlhkgdsspasssshsrr---------------------------hvhssksstvdqtykesnhsKSPAEQDFGSHGV- 278  spotted gar
XP_004042541  178 ssspGKPQAvsslssshsrsh---------------------------------gndhhskehqrsKSPRDPDANWDSPs 224  western lowla...
XP_002664429  199 sspnpngpttsshss---------------------------------rkqaqagkgpataelglgKSPAEQDSCSHGs- 244  zebrafish
XP_011609585  171 shtsspakgslsssssss-----------------------------hlrsslaaeqhhgkeryrsKSPREREPNWDSPs 221  torafugu
XP_002935317  174 sispGKQSAlnsshsrahgn------------------------------------dhhskerphaKSPRDPDANWDSPs 217  western clawe...
XP_007507324  259 sdqhknggmedasmstsssn------------------------srrlshskasggdhfykesipcPSPIDFEFLANGP- 313  gray short-ta...
XP_004076172  168 shtsSPAKSslsssgsqsrgsl-------------------------------saeqhhckeryrsKSPLDREANWDSPs 216  Japanese medaka
XP_011478777  263 kdvlGLKEDsspsssssssssssssrrqsshsskthslpdgsfrssttdachfksssntenggsfkLSPYENESGSQLSl 342  Japanese medaka

O88573        237 tphDGLVAVTSLG--------SAPPQPPCQTFPPPpLPSKSa-A-MQQKPTAYVRPMDGQDQAPSESPELKLP-L--E-- 301  house mouse
XP_006003261  223 --------rVHIF--------SSSGQHSSQSFPPC-LMSKSs-S-MLQKPTAYVRPMDGQ-----ESMESKVP-S--E-- 273  coelacanth
XP_006633106  279 ---SSPLPSTSLI----------PSGLSTPNFPPV-LHSKPs-I-IQQKPTAYVRPMDGQDQVPNDSPDLKTP-A--Eig 339  spotted gar
XP_004042541  225 --rVP----------------FSSGQHSTQSFPPS-LMSKSn-S-MLQKPTAYVRPMDGQ-----ESMEPKLS-S--E-- 273  western lowla...
XP_002664429  245 ---SSPLASTSLL----------PSGLSTPTFPQG-LHCKPssA-VQQKPTAYVRPMDGQDQVPNDSPELKPP-V--Elv 306  zebrafish
XP_011609585  222 --------rVHTS--------FPSGQHSSQAFPPS-LMSKPg-S-MLQKPTAYVRPMDGQ-----ETAEPKSSqA--E-- 273  torafugu
XP_002935317  218 --rAP-------S--------FSSGQHSSQAFPPS-LMSKSn-S-MLQKPTAYVRPMDGP-----ESMEPKLS-S--E-- 267  western clawe...
XP_007507324  314 ---ISPLSSTSLL--------SSASSLSVQNFPQG-LYCKTs-M-VQQKPTAYVRPMDGQEQLPDFSPALKPL-L--Eie 376  gray short-ta...
XP_004076172  217 --------rVHTS--------FPSGQHSSQSFPSS-LMPKTs-S-MQQKPTAYVRPMDGQ-----ETAEPKSSqA--E-- 268  Japanese medaka
XP_011478777  343 --nSSPLASTSILttptpgltTPTSGLMTPTFPPGtLSGKP--IaVQQKPTAYVRPMDGQDQTPMDSPQLKPPlVaaE-- 416  Japanese medaka

O88573        302 -DYGQ-QSF-E-Kpdl--kvP---A---KAKLTRLRMPsQSVEQPYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPS 369  house mouse
XP_006003261  274 -HYSS-QPN-S-TsmseiksS---S---KAHLTKLKIPsQPLDATMSGDVSCVDEILKEMTQSWPPPLTAIHTPCKTDSS 343  coelacanth
XP_006633106  340 dGYNN-PSF-G-Gmid-gkaN---AtnaKSKLPKLTLP-QPGEVSLSNESSCVEEILREMTHSWPPPLTAIHTPGKADQT 411  spotted gar
XP_004042541  274 -HYSS-QSH-GnSmte-lkpS---S---KAHLTKLKIPsQPLDASASGDVSCVDEILKEMTHSWPPPLTAIHTPCKTEPS 343  western lowla...
XP_002664429  307 eGYNT-VPF-G-Glld-tksS---TtgtKGKIPKLTLP-QSGEVSLPNDSNCVEEILREMTHSWPPPLTAIHTPGKAEQT 378  zebrafish
XP_011609585  274 -SYSG-QSH-SsTmge-mksN---G---KASLSKLKIPsQPVEG--SGDANCVDEILKEMTQSWPPPLTAIHTPCKTEPS 341  torafugu
XP_002935317  268 -HYSS-QSH-G-SsmnelkpN---S---KAHLTKLKIPsQPVDASASGDVSCVDEILKEMTHSWPPPLTAIHTPCKTEPS 337  western clawe...
XP_007507324  377 sGYSS-QTF-G-Tlle-gkpS---AttaKTKLPKLTIP-QPSEINLSNDPNCVEEILR---------------------- 426  gray short-ta...
XP_004076172  269 -SYSG-QPHsG-Pmge-mksN---G---KASLTKLKIPsQPVEG--SGDANSVAEILKEMTQSWPPPLTAIHTPCKTEPS 336  Japanese medaka
XP_011478777  417 -GFSNgQSF-S-G-------AsgnA---KNKLPKLSLS-HTEEVSLPNESSCVEEILREMTHSWPPPLTAIHTPGKAEQT 482  Japanese medaka

O88573        370 RFPFPTKDPLHVSPATQSqKQYDTPSKT---HPNPQQG----T-S-------MLEDDLQLSDSEDSDTE----------- 423  house mouse
XP_006003261  344 KFPFPTKDTQHSNFAVGTqKRYNAPSKT---SSSGHQS----K-ScdsdqknMLQDDLKLSSSEDSDGE----------- 404  coelacanth
XP_006633106  412 KFPIPSKDSQHLTSGYNGqKRCNVPSNK---PATK-----------------MLEDDLKLSSDEE-DSE----------- 459  spotted gar
XP_004042541  344 KFPFPTKESQQSNFGTGEqKRYN-PSKT----SNGHQS----K-S-------MLKDDLKLSSSEDSDGE----------- 395  western lowla...
XP_002664429  379 KFPIPSKDSQHVTSGY-NaKRCSVPSNK---PATKSVPq---K-S-------MLEDDLKISSDEE-DND----------- 431  zebrafish
XP_011609585  342 KFPFPTKDSHPFPSGh---KRGSSSKSS---SSHQPKTcddqP-T-------MLEDDLKLSSSEDSDGE----------- 396  torafugu
XP_002935317  338 KFPFPTKDTQQSSFPSCEqKRYN-PSTK---TTNGHPT----K-S-------SLKEDLKLSSSEDSDGD----------- 390  western clawe...
XP_007507324  427 -------DLQLSTSAYSVqK-WSDPEIK---AATKPPVp--qK-S-------MLEDDLKISSDEDEI-E----------- 473  gray short-ta...
XP_004076172  337 KFPFPTKEAHPFPSGh---KRGSSSKSS---SSHQTKD----G-S-------MLKEDLMISSSEDSDGE----------- 387  Japanese medaka
XP_011478777  483 KFPIPNKEAQHVTSSYNP-QKRCPVPANkpaAKAPTAP----QkS-------MLEDDLKISSD-EEEAEqapdknkargt 549  Japanese medaka

O88573        424 ---QATEKPPSPP-APPSAPQTLP-EpVASAHSSSGESES-SESDSS--SDSE-SESSSSDSeeeEENEPLETRAPEPEP 494  house mouse
XP_006003261  405 ---QDSEKPVPRN-TPGSNSDPTQ-HnGEGADNSRDDSSSpSGSESSsgSDSE-SESSSSDS---EANEPSRSASPEPEP 475  coelacanth
XP_006633106  460 ---QATQKTKHRSlVFLLLPGSTA-RtAEPGHSSGASGSSsESESSSesD-SD-SESSSSDS---ECNEGSRSATPEPEP 530  spotted gar
XP_004042541  396 ---QDCDKTMPRS-TPGSNSEPSH-HnSEGADNSRDDSSShSGSESSsgSDSE-SESSSSDS---EANEPSQSASPEPEP 466  western lowla...
XP_002664429  432 ---QAAEKPKPRS-TALNLPGSTAvRsSEAAGHSSGASGSsSESESSseSDSD-SESSSSDS---ECNRASRAATPEPEP 503  zebrafish
XP_011609585  397 ---QDSAKNASRN-TSQGS------NnSEGAEQSRDDSSShSGSESSsgSDSE-SESSTTDS---ETNEHPRPASPEPEQ 462  torafugu
XP_002935317  391 ---QECDKTMPTN-TPGS-SEPSQ-NnSEGAENSRDDSSShSGSESSsgSDSE-SESSSSDS---EANEPSRSASPEPEP 460  western clawe...
XP_007507324  474 ---QDIEKAKTMD-IPSNPTVPPA---PEPVVIPSSGGSEsSSSDSSseSDSD-SESSSSDS---EGNEESRSNTPEPEP 542  gray short-ta...
XP_004076172  388 ---QE-AKNASRN-TSAS-------NnSEAAEQSRDDSSShSGSESSsgSDSE-SESSTSDS---EANEPPQPAS--PDP 449  Japanese medaka
XP_011478777  550 tasGGSG--------------------------------SsSESESSseSDTDeSESSSSDS---EYNQASRTNTPEPEP 594  Japanese medaka

O88573        495 PTTNKWQLDNWLTKVN----Q----PSVPLDGR--G-----STESpq--wrQESKGVAE--GSSD-QQHPD-S------- 546  house mouse
XP_006003261  476 PPTNKWQLDNWLNKVN----P----HKVSPASSvdS-----NVPSsqg-ykKENRDQSTgsGY-SaQSGSKdS------- 533  coelacanth
XP_006633106  531 PSTNKWQLDKWLNKVN----PhnktLINTQPES--H-----GLNSsqsddsHQTEGQGSgkGKPSmSLVQPdPker---- 595  spotted gar
XP_004042541  467 PPTNKWQLDNWLNKVN----P----HKVSPASSvdS-----NIPSsqg-ykKEGREQGTgnSYTDt-SGPKeT------- 524  western lowla...
XP_002664429  504 S---KWQLDKWIKKVN----PhnkaLINTQADS--H-----GLNSsqpdesQTSENQSYskSKPStALAPAdPker---- 565  zebrafish
XP_011609585  463 PMSNKWQLDNWFKKAK----Q----LSPASPVD--S-----NVPTkc---kKEGRENSSgrGYGSqGGGSKdS------- 517  torafugu
XP_002935317  461 PPSNKWQLDNWLNKGN----P----HKVSPASSveS-----NIPSsqg-ykKDSQEQGAgtGYAEp-SGPKeS------- 518  western clawe...
XP_007507324  543 PSTNKWQLDKWLNKVN----PqnktIISNQNET--S-----NENNpl--lsITPQTEVQnkAKVTpGLFQIePker---- 605  gray short-ta...
XP_004076172  450 QGSNKWQLENWIKK---------------TQDN--N-----NTPPky---kKEGRDNSSgrGHGNqGGGSKdS------- 497  Japanese medaka
XP_011478777  595 PSTNKWQLDSWLNKVQaqtkP----LPPPQQEL--HgtgssSQDSq----pFSPRNEAAg-----vGTAAKsKpsgsnsv 659  Japanese medaka

O88573        547 ------------------KDPLPKSSSKTLRGPS-EGPsl---grGAVRN-Pp---LNRNPHLGK--PWAANNP-GNPPR 597  house mouse
XP_006003261  534 ------------------SASTPGRDSRATQKGS-ESS-------RGRQK-Spa-qSDSSTTQRK--TVGKKQP-KKAEK 582  coelacanth
XP_006633106  596 ---------------vllSPIRDKAKPRTGQKTP-EGk-------ITKLK-Spa-nIELAPP-RR--TTGKKQP-KKVER 646  spotted gar
XP_004042541  525 ------------------SSATPGRDSKTIQKGS-ESG-------RGRQK-Spa--qSDSTTQRR--TVGKKQP-K-KAE 571  western lowla...
XP_002664429  566 ---------------tllSPIREKAKPKAGQKAP-DSk-------STKVK-Spa-sVELAPP-RR--STGKKQP-KKVER 616  zebrafish
XP_011609585  518 ------------------TAPTPNRDLRAAQKGA-EGG-------RGRQK-Spa-qSEGGPNPRR--SVGKKQP-KKSEK 566  torafugu
XP_002935317  519 ------------------NTSTPGRDSKAAQKGS-ENS-------RGRQK-Spa--qSESTTQRK--TIGKKQP-KKTEK 566  western clawe...
XP_007507324  606 ---------------pllSPLREKARQRLMQKPP-PPPpppleakTSRQK-Spa---qNEAASQK--IIVKKQP-QKVER 662  gray short-ta...
XP_004076172  498 ------------------ALPPPSRDLRAPQKGA-EGG-------RGRQK-Spa-qCESGTNSRS--RVGKKQP-KKSEK 546  Japanese medaka
XP_011478777  660 pvpaapvvehkdtratfcS-GREKAKAKTNQKASgESQ-------RSKIRlSpgllSGQEVTTPRrtTTGKKQPvGRVER 731  Japanese medaka

O88573        598 lRPGRAQ-----------ASSQAESEvgplpYGSKEQTSKDRPKVKTKgr-pRAVGSREPK------------------- 646  house mouse
XP_006003261  583 -ATLVEEp---------rGGLKVESEi---pPEMPTSIPPNRHKAATKgs-rKPNIKKEPK------------------- 629  coelacanth
XP_006633106  647 -PPSAEEynwlk--pnnpSSTPKEKEp---pPLE---QSKARNKAgn----gKTAPRKEPR------------------- 694  spotted gar
XP_004042541  572 -KAAAEEp---------rGGLKIESEt---pVDLASSMPSSRHKAATKgs-rKPNIKKESK------------------- 618  western lowla...
XP_002664429  617 -SSSSEEh---------nWPRPGNSSs---tPKEKEPPPLEPPKPRGKgpvvKTAPRKEPR------------------- 664  zebrafish
XP_011609585  567 -PPVVEEp---------kGGLRVESEp---aPEI----PPHRPKAATKgs-rKPSIKKEPK------------------- 609  torafugu
XP_002935317  567 --SAVEAp---------rGGLKIESVt---tTEITTNLPPNRHKAATKgs-rKPNIKKEPK------------------- 612  western clawe...
XP_007507324  663 tPSTEEYpwsrp--nihpSNTPKEKD-----TLEHPEQAKARNRAAVG----KLAPRKEPK------------------- 712  gray short-ta...
XP_004076172  547 -PPVVEEp---------kGGLRVESEt---aPVV----PHTRQTAGTKgp-rKPSTRKDLK------------------- 589  Japanese medaka
XP_011478777  732 sASGEDNqnqtwsranqhSPTSREKDllpppPLEHQNPPRPRSKPPSG----KTAPRKEPRsatnpnnnaatppaalqqs 807  Japanese medaka

O88573        647 ----P--------EVpaptpqaavprpkppvptPS-------E-------KRKHKSs--TAPSKAPSAPQPP---KDSA- 694  house mouse
XP_006003261  630 ----S--------SPr----------------pAV-------E-------KRKYKSsskPPQNKSREIIETD---TTSS- 663  coelacanth
XP_006633106  695 ----S--------NPag---------------pAQ-------D-------KKKHRGa-tKIIPKSKEFIETE---SSSSe 729  spotted gar
XP_004042541  619 ----S--------SPr----------------pTA-------E-------KKKYKSt-sKSSQKSREIIETD---TSSS- 651  western lowla...
XP_002664429  665 ----TtttstaptNIa----------------pVP-------D-------KKKHRGp-nKIIPKSKEFIETE---SSSSe 706  zebrafish
XP_011609585  610 ----S--------SPr----------------pTPaavtsaaD-------KRKPKAp-tKTSQKSREFVDTD---SAAS- 649  torafugu
XP_002935317  613 ----S--------SPr----------------pAT-------E-------RKKYKPs-kPSQ-KSREFVETD---TSSS- 644  western clawe...
XP_007507324  713 ----L--------TAa----------------fIA-------E-------KKKFRGp-gKIAPKSREFVETDs-sTSDS- 747  gray short-ta...
XP_004076172  590 ----S--------SPr----------------sAA-------ApapiapgKRKAK------PPQSREVVSTD---PSSS- 624  Japanese medaka
XP_011478777  808 aapvP--------AVt----------------vNQ-------D-------KKKHRGpstRITPKSREFIETDsssSSEC- 848  Japanese medaka

O88573        695 -GDRNPEHSALVSL---T--------------------------------------------------------Q----S 710  house mouse
XP_006003261  664 -DSEENEN------------------------------------------------------------------------ 670  coelacanth
XP_006633106  730 cHSDPEELVKIPPPcpgP--------------------------------------------------------N----N 749  spotted gar
XP_004042541  652 -DSDESESLP-------P--------------------------------------------------------S----S 663  western lowla...
XP_002664429  707 cHSDPEELTKVQLP---C--------------------------------------------------------P----G 723  zebrafish
XP_011609585  650 -DSEGNDSIPSS-------------------------------------------------------------------S 661  torafugu
XP_002935317  645 -DSDENESLP-------P--------------------------------------------------------S----S 656  western clawe...
XP_007507324  748 -NTDQDEALQVKPV---P--------------------------------------------------------P----C 763  gray short-ta...
XP_004076172  625 -DSEGNDSIPSS-------------------------------------------------------------------S 636  Japanese medaka
XP_011478777  849 -QSDAEEAVKMPAL---PaqtsrstintqtlssthmhtalqpcpasanpvgslgangrtgfrvkdgsilttngsSsvssS 924  Japanese medaka

O88573        711 ----------QG----------PSHSS---------R--------------------Gssgsvrtsgcrqa-------vi 734  house mouse
XP_006003261  671 ----------------------NSEGR---------T--------------------Snnksgleee------------- 686  coelacanth
XP_006633106  750 ----------IG----------LLKSK---------D--------------------Cnsnilsvssltstssasidpsn 780  spotted gar
XP_004042541  664 ----------QT----------PKYPE---------S--------------------Nrtpvkpssve------------ 682  western lowla...
XP_002664429  724 ----------PN----------TLSLK---------SkdcnsnilsvssltstsstsIpdpgasdl-------------- 760  zebrafish
XP_011609585  662 ----------QT----------PKYTE---------S--------------------Irtp------------------- 673  torafugu
XP_002935317  657 ----------QT----------PKYSE---------S--------------------Nrtppakpsve------------ 675  western clawe...
XP_007507324  764 ----------PTltsalkpkeaPSNTI---------F--------------------Nvstltgsssscssssslcldia 804  gray short-ta...
XP_004076172  637 ----------QT----------PKYTE---------S--------------------Irtp------------------- 648  Japanese medaka
XP_011478777  925 snslsistisTT----------FGISVpdpggtggqS--------------------Kvep------------------- 955  Japanese medaka

O88573        735 aqgdgckdklLLPLRDT--KLLSPLRDSPPP--------TS--------LVVKITLDLLTRIPQplgKgsrprkAEDK-Q 795  house mouse
XP_006003261  687 --esflrqrmFSPMEEK--ELLSPLSDPDDRyp----vvQS--------LIVKIDLSLLSRIPGrpyKeaqqpkVEKKsL 750  coelacanth
XP_006633106  781 gdlledhlfsPIPMVQNvaELLSPLRDFEEI--------KS--------LWVKIELSFLSRIPGqdpPestpvkAEPRdS 844  spotted gar
XP_004042541  683 eedsffrqrmFSPMEEK--ELLSPLSEPDDR--------YP--------LIVKIDLNLLTRIPGkpyKeteppkGEKKnV 744  western lowla...
XP_002664429  761 ---leehlfsPIPIVQN--ELLSPLRDFEDI--------KS--------LWVKIELSFLSRIPGqdpPeppptkAECReV 819  zebrafish
XP_011609585  674 -------vcvFSPMEEK--ELLSPLSDPEERyparqpqqQV--------LLVKIDLNLLSRIPGrpyKdpveikVERDdS 736  torafugu
XP_002935317  676 eedsffrqrlFSPMEEK--EPLSPLSEPEER--------YP--------LIVKIDLSLLSRIPGrpyKeveqpkVE-KsA 736  western clawe...
XP_007507324  805 tneveeplfsPLPIGQT--ELLSPIRDYDDT--------KA--------LWVKIDLDLLSRVPGqdp----petTSMKsE 862  gray short-ta...
XP_004076172  649 -------vcmFV-TEDK--ELLSPLSDPEDR--------YPprpphqevLLVKIDLSLLSRIPGrpyKepseikVESEdS 710  Japanese medaka
XP_011478777  956 --------lsPSNVGQE--VPPSPLREYHEI--------QS--------LWVKIDLSLLSRAPG---Qgvgersrvgiae 1006 Japanese medaka

O88573        796 LSAGKKQ-DSETK--S--------------CDSSSRVTKKRKVTq--------KKSTVTRDTnwISRRASSSS--SHT-- 846  house mouse
XP_006003261  751 QEKHTRE-SLKQA--S--------------DKSSNKGKRKHKNEdesg-ssenKKSKLEGRG---------SS--SHK-- 799  coelacanth
XP_006633106  845 SNKHRRQsPASAT--A--------------EKPSSKTKRKHKSEncda-vngnKKLRLEKET--LLLPPCISPihNHK-- 903  spotted gar
XP_004042541  745 PEKHTRE-AQKQA--S--------------EKVSNKGKRKHKNEddnr-asesKKPKTEDKN---------SA--GHK-- 793  western lowla...
XP_002664429  820 SVKHRRQ-QSPASipA--------------EKNPSKSKRKHKSEhcdv-msggKKLRLDKDT--LLLPPCISPihNHK-- 879  zebrafish
XP_011609585  737 LDRDGKD-CSKPI--S--------------EKSSSKAKRKHKNDeess-kpesKRCKLEEKS---------LS--HHK-- 785  torafugu
XP_002935317  737 PEKHTKE-SQKQT-----------------DKSSTKGKRKHKNDdesr-gndsKKPKLEEKA----------S--SHK-- 783  western clawe...
XP_007507324  863 PRDNIKP-PQTQT--PqipqarespgpsfaDKMSGKNKRKFKPSdhldlfpenKKQRLEDGPvsSLFPPCISP--IPSsq 937  gray short-ta...
XP_004076172  711 P-------DRDAN--N--------------KKSSIKLKRRHKNDdess-kpgsKRFKPEGKSa---------Q--HHK-- 753  Japanese medaka
XP_011478777 1007 reesegrdrerlklnkgerqveenerllllregqadrddrdrfafgerdrtrdrekicqglgildnppvqehgnprpsgr 1086 Japanese medaka

O88573        847 --ESSRTkAPRSSSENSRKEMLPPASASSVSSSSSSqkpsrpaqKRPRPDEDTCSQEPPrsas-stksSSTDP-PA---- 918  house mouse
XP_006003261  800 --TSTNk-ESTKHVAEKEKEPLPSPSVPLPQKESKTehq---srKRTVSQSSN-SKLGAssnk-esggSSSKG-NS---- 866  coelacanth
XP_006633106  904 --LTS-TkDSLKKQPRKREEKLLPPPLSPLSDEPLh--------LRRNTESSSFIQEGStsst-stlpTHSTSaTS---- 967  spotted gar
XP_004042541  794 --PSSNRe-SSKQSAAKEKDLLPSPAGPVPSKDPKTehg---srKRTISQSSSLKSSSNsnke-tsgsSKNSS-ST---- 861  western lowla...
XP_002664429  880 --VSS-TkDSLKKQPRKKDDKLLPPLLSPLSVEPvg-------rPRRSSECSSLSQEGStstipnnlpSSRTI-PAssss 948  zebrafish
XP_011609585  786 --NSSKE---SKRSLEKKEEPVPSPSLSGLQRPPKVehp---srKRTVSQSSTSLSSGTgsgk-egnhSTKSN-ST---- 851  torafugu
XP_002935317  784 --SSNKE--SSKQNPVKEKDPLPSPAQPVQQKDSKTdhi---prKRTXSQSSS--LKSGssgs-ikesSSKSS-SS---- 848  western clawe...
XP_007507324  938 rfPSTKEnVLAKKVAKKRDDKLFPPPLSPLSDEPLHr-------RISSDSKSSFSQEVFmpta-fpaaS---C-SF---- 1001 gray short-ta...
XP_004076172  754 --NGVKE---SKRSLDKKEEPVSPASMPGLQRTPKAehp---srKRTASQSSTSLSSGTgsgk-egsqSAKSS-ST---- 819  Japanese medaka
XP_011478777 1087 gepaeggaknrrqstantplsaekhaskskrkhkldhgepsgrcskkvrldkdclllppcispihnhknssadtfsrkqt 1166 Japanese medaka

O88573        919 ------PKHRKVQARG------S-----------EHKGSSG-------Daa----nAANPFPVPS-L-PN-GNAKPGKPQ 961  house mouse
XP_006003261  867 ------SKHKKTEEKA------Ags-------akEGKVKVP-------S-------SAANCPPPS-A-PS-ADMKLRRQK 910  coelacanth
XP_006633106  968 ------NRHRKGENKM------VthsktvseedaHSKPPSGlvg-ngqS-------DPDLWSNLS-S-TSlDHLEPRRPK 1025 spotted gar
XP_004042541  862 ------SKQKKTEGKT------Sss-------skEVKEKAP-------S-------SSSNCPPSA-P-TL-DSSKPRRTK 905  western lowla...
XP_002664429  949 ssssssHKHRKGENKA------Fshskt-steedSHSKPSGgfhgngqS-------EADLWSNPSaL-TM-EHMEPRRPK 1012 zebrafish
XP_011609585  852 ------SKHRKGDDKG------Rst-------rdGKEKSSK-------S-------CDNQLAVPP-L-ST-DGSKSQRSK 895  torafugu
XP_002935317  849 ------AKQRKTEGKS------Tss-------akDPKEKSA-------N-------STAAVAFIP---PI-DN-KSQRAK 890  western clawe...
XP_007507324 1002 ------ARPRKNESKThlnfriCge-------dtYNRGPSI-------GllnsnqlEMATWSSMS-SmAN-GSVETRRPR 1059 gray short-ta...
XP_004076172  820 ------PKHRKGEDKG------Kt---------rDSKEKSS-------K-------SCDNQLVPP-L-SS-DGSKSQRSK 861  Japanese medaka
XP_011478777 1167 rrhddkmlppllsplsdepprkatcdsstpisqeggapgrlpcsyaptssschrhkrgegkasshvrngiemnshgdklc 1246 Japanese medaka

O88573        962 VKSD-RQ-QADFHMKEAKKLKCKAETMVDKAGKAFKYLEAVLSFIECGMASESES-SAKSAYAVYSETIDLIRYVMSLKC 1038 house mouse
XP_006003261  911 LTFDdRVySADHYLQEAKKLKHNADALSDRFDKAVYYLDAVVSFIECGNALERSAqESKSPFPMYSETVELIKYTMKLKN 990  coelacanth
XP_006633106 1026 LTFDdTLqNADHYMQEAKKLKHKADALMEKFGKAVNYADGALSFIECGNAMERDPlEAKSPYTMYSETVELIRYAMRLKN 1105 spotted gar
XP_004042541  906 LVFDdRNySADHYLQEAKKLKHNADALSDRFEKAVYYLDAVVSFIECGNALEKNAqESKSPFPMYSETVDLIKYTMKLKN 985  western lowla...
XP_002664429 1013 LTFNsTVhSADYYMQEAKKLKHKADALMDKFGKAVNYADGALSFIECGNAMERDPlEAKSPYTMYSETVELIRYAMRLKN 1092 zebrafish
XP_011609585  896 LMFEdRVhSADHYLQEAKKLKHNADALLDRFEKAVYYLDAVVSFIECGNALEKSAqEAKSPFPMYAETVELIKYTMKLKS 975  torafugu
XP_002935317  891 LVFEdRIhSADHYLQEAKKLKHNADALSDRFEKAVYYLDAVVSFIECGNALEKSVqESKSPFPMYSETVELIKYTMKLKS 970  western clawe...
XP_007507324 1060 IHFDnMPhSADYYMQEAKKLKHKADALVEKFGKAIYYTDAALSFIECGNAMERDPlEAKSPYTMYSETVELIRYALRLKN 1139 gray short-ta...
XP_004076172  862 LVFEdRVhSADHYLQEAKKLKHNADALVNRFEKAVYYLDAVVSFIECGNALEKSAqEAKSPFPMYAETVELIKYTMKLKS 941  Japanese medaka
XP_011478777 1247 geghhansqsdsevwleplmdsteprrprlsftdtvrgadyymqeakrlkhkadalmdkfgkavnyadgalsfiecgnam 1326 Japanese medaka

O88573       1039 FSDNTMPAQEKIFAVLCLRCQSLLNMAMFRCKKDTVMKYSRTLSEHFKSTSKVAQAPSPCTArs---tGVPSPLSPMPSP 1115 house mouse
XP_006003261  991 YMAPDATAADKRLAVLCLRCQSLLYLRLFKLKKESALKYSKTLTEHLKNSYNNSQAQSPGsk----ptGMPSPVSPKLSP 1066 coelacanth
XP_006633106 1106 FTGQSATVGEKKLAVLCYRCLSLLYLRMFKLKKDHAMKYSRSLMEYFKNSVKSSQAPSPWGAngk-stGTPSPMSLSPSP 1184 spotted gar
XP_004042541  986 YLAPDATAADKRLTVLCLRCESLLYLRLFKLKKENALKYSKTLTEHLKNSYNNSQAPSPGLGsk--avGMPSPVSPKLSP 1063 western lowla...
XP_002664429 1093 FTSHSATIAEKKLAVLCNRCLSLLYLRMFKLKKDHAMKYSRSLMEYFKNSAKSSQAPSPWGAngk-stGTPSPMSLSPSP 1171 zebrafish
XP_011609585  976 YMAPDATSADKRLAVLCLRCQSLLYLRLFKLRKDSALKYSKTLTEHLKNSLSNTQAPSPGMGnk--aaGMPSPVSPKLSP 1053 torafugu
XP_002935317  971 SAAPDATAADKRLGVLCLRCQSLLYLRLFKLKKESALKYSKTLTEHLKNSYSNSQAPSPGMGsk--svSMPSPVSPKLSP 1048 western clawe...
XP_007507324 1140 FTCSSSTEWDKRLAILCYRCLSLLYLRMFKLKRDHAMKYSRSLMEYFKTSSKAAQIP---WGnygksaEVM--------- 1207 gray short-ta...
XP_004076172  942 YMAPDATSADKRLAVLCLRCQSLLYLRLFKLRKDSALKYSKTLTEHLKNSLSNTQAPSPGMAnk--aaGMPSPVSPKLSP 1019 Japanese medaka
XP_011478777 1327 erdpleakspytmysetveliryamrlknftshsatvlekrlavlcnrcqsllylrmfhlkkdhavkysrslmeyfknsa 1406 Japanese medaka

O88573       1116 ASSVGSqssagssmgsvgvTATVSTPVSIQNMTSSYVTITSHVLTAFSLWEQAEALTRKNKEFFAQLSTKVRVLALN-SS 1194 house mouse
XP_006003261 1067 GNTGSYssaan---npsgsSSSVTIPQRIHQMAASYVQVTSNFLYGTEVWDQAEQLAKEQKDFFTELDKVMNPLMFNtST 1143 coelacanth
XP_006633106 1185 VGSVSSttgtv----gsssTGSIAIPHRIHHMAASHVNITNNILRSYEHWDTAEKLSRESQEFFQELNSVMGPLTQH-ST 1259 spotted gar
XP_004042541 1064 GNSGNYssgas---sasasGSSVTIPQKIHQMAASYVQVTSNFLYATEIWDQAEQLSKEQKEFFAELDKVMGPLIFNaSI 1140 western lowla...
XP_002664429 1172 VSSVSSsagam---gsssaSGSVAIPQRIHHMAASHVNITNNILRSYEHWETADKLAQESQEFFVELDSVMEPLTQH-SS 1247 zebrafish
XP_011609585 1054 GTAGGYssvss---sssasSSV-TIPQRIHQMAASYVQVTSNFLYATEVWDQAEQLSKEQKDFFSELDKVMGPLIFNtSS 1129 torafugu
XP_002935317 1049 GNSNNYsssvs---sssgsTSSVTIPQRIHQMAASYVQVTSNFLYATEIWDQAEQLCKEQNDFFTELDKVMGPLIFN-SS 1124 western clawe...
XP_007507324 1208 -SPLSLspsss---nalpsLGPIVIPHRIHHMAASHVNITNNVLRGYEHWDMADRLTRENREFFADLDSLMGPLTQH-ST 1282 gray short-ta...
XP_004076172 1020 GSASGYvsssn---ssassS--VTIPQRIHQMAASYVQVTSNFLYATEIWDQAEQLSKEQKDFFLELDKMMGPLIFNtSS 1094 Japanese medaka
XP_011478777 1407 ksshqapspwrtngkvngtpsplslspssvssggaagggggasgssgsvaipqrihhmaashvnitnnilrsyehwetad 1486 Japanese medaka

O88573       1195 -LVDLVHYTRQGLQRLKQSP 1213 house mouse
XP_006003261 1144 -MTDLVRYTRQGLHWLRLDA 1162 coelacanth
XP_006633106 1260 -MTELVRYARQGLHWLRIES 1278 spotted gar
XP_004042541 1141 -MTDLVRYTRQGLHWLRQDA 1159 western lowland gorilla
XP_002664429 1248 -MTELVRYIRQGLHWLRLEA 1266 zebrafish
XP_011609585 1130 -MTELVRYTRQGLHWLRLDA 1148 torafugu
XP_002935317 1125 tMTELVRYTRQGLHWLRLDA 1144 western clawed frog
XP_007507324 1283 -MTNLVRYIRQGLYWLRLEA 1301 gray short-tailed opossum
XP_004076172 1095 -MTELVRYTRQGLHWLRLDA 1113 Japanese medaka
XP_011478777 1487 rlaaeshnffqeldavmepl 1506 Japanese medaka
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