1IOJ


Conserved Protein Domain Family
ApoC-I
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pfam04691: ApoC-I (this model, PSSM-Id:282537 is obsolete and has been replaced by 428068)
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Apolipoprotein C-I (ApoC-1)
Apolipoprotein C-I (ApoC-1) is a water-soluble protein component of plasma lipoprotein. It solubalises lipids and regulates lipid metabolizm. ApoC-1 transfers among HDL (high density lipoprotein), VLDL (very low-density lipoprotein) and chylomicrons. ApoC-1 activates lecithin:choline acetyltransferase (LCAT), inhibits cholesteryl ester transfer protein, can inhibit hepatic lipase and phospholipase 2 and can stimulate cell growth. ApoC-1 delays the clearance of beta-VLDL by inhibiting its uptake via the LDL receptor-related pathway. ApoC-1 has been implicated in hypertriglyceridemia, and Alzheimer's disease.
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Statistics
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PSSM-Id: 282537
Aligned: 11 rows
Threshold Bit Score: 73.6878
Created: 11-Jul-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1IOJ_A         1 TPDVSSAL----DKLKEFGNTLEDKARELISRIKQSELSAKMREWFSETFQKVKEKLKID 56  human
P02654        27 TPDVSSAL----DKLKEFGNTLEDKARELISRIKQSELSAKMREWFSETFQKVKEKLKID 82  human
P0CE37        27 aPEVSNPF----DGLEELGKTLEDNTREFINRITQSELPAKMWDWFSETFRKVKEKLKID 82  chimpanzee
P56595        27 AGEISSTFeripDKLKEFGNTLEDKARAAIESIKKSDIPAKTRNWFSEAFKKVKEHLKTA 86  dog
XP_008250470  74 APDF-STLelipDKLKEFGNTLEEKARMAIEHIKQSEITTKTRNWFSETISKVKEKFKST 132 rabbit
XP_003464714  27 APDLGSALeslpGKLKEFGSTVESKARAAIEHIKQSDFPTKTWKWLSKTVSKVREKFKAT 86  domestic guinea pig
XP_004873200  27 APDFTSTLeglpAKLKEFGSILEDKALAAIEHIKQSELPAKTRNWFSDAFSKVQEKFKAT 86  naked mole-rat
XP_007491635  52 sssLAQSFeqfqKKVKEFTETVVEKTKAAITQIKHSDLPSKTRTWITENIQKVKDKVEST 111 gray short-tailed opossum
NP_001278815  24 EPTLEQHFtkfgTQMKEIAEDLADKTKTAFQNIEQSELGTKTRNWFNDQYEKLKQKMTET 83  zebrafish
XP_007231203  23 EPTIEQHFasfhTKVKEFGSDVAEKTMATIKEIEQSEFAAKTKNWFTEQFEKMKKQFDET 82  Mexican tetra
P19939        27 APDFSSAMeslpDKLKEFGNTLEDKARAAIEHIKQKEIMIKTRNWFSETLNKMKEKLKTT 86  Norway rat
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